CRSP vs LEGN Stock Comparison

CRISPR Therapeutics AG and Legend Biotech Prices as of Oct 23, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$49.39 -11.4% 1M -26.5% 1Y
Market cap
$4.73B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins
LEGN Legend Biotech Corp
$19.27 +4.4% 1M -39.2% 1Y
Market cap
$3.76B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

9 decided of 12

CRISPR Therapeutics AG leads on 5 of the 12 questions below (CRISPR Therapeutics AG 5, Legend Biotech 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPLEGNLeader
Larger companyMarket capitalisation $4.73B $3.76B CRSP
Cheaper on earningsLower P/E, profitable companies only -10.5x -41.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — –
Faster revenue growthRevenue growth, trailing twelve months -64.8% +59.5% LEGN
More profitableNet margin, trailing twelve months -3,368.7% -7.2% LEGN
Better return on capitalReturn on invested capital -22.6% -4.2% LEGN
Less leveragedLower net debt / EBITDA 3.4x 28.0x CRSP
Higher dividend yieldTrailing dividend yield 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -26.5% -39.2% CRSP
Better 5-year returnAnnualised price return, 5 years -12.4%/yr -18.4%/yr CRSP
Less volatileAnnualised volatility, 1 year 57.0% 71.7% CRSP
Higher overall scoreMean of the five percentile scores vs peers 44/100 72/100 LEGN

Percentile Scorecard

CRSPLEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPLEGN
Valuation 48 #324 of 624 89 #67 of 624
Growth 32 #413 of 603 97 #20 of 603
Profitability 32 #379 of 555 80 #114 of 555
Financial Health 71 #190 of 657 54 #306 of 657
Shareholder Returns 37 #232 of 370 41 #219 of 370
Overall 44 72
  • CRSP ranked among 671 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPLEGNSPY
1 month -11.4%+4.4% -1.0%
3 months +6.1%-13.3% +2.9%
6 months +1.2%-19.4% +6.4%
Year to date -5.8%-11.4% +11.4%
1 year -26.5%-39.2% +13.1%
3 years +19.0%-71.1% +79.4%
3 years, per year +6.0%-33.9% +21.5%
5 years -48.3%-63.7% +67.7%
5 years, per year -12.4%-18.4% +10.9%
10 years +257.4%— +255.2%
10 years, per year +13.6%— +13.5%

Risk

MeasureCRSPLEGNSPY
Volatility, 1Y 57.0%71.7% 12.7%
Downside volatility, 1Y 53.8%62.7% 12.7%
Beta vs S&P 500, 1Y 1.790.40 1.00
Return / volatility, 1Y -0.46-0.55 1.03
Max drawdown, 5Y -67.7%-78.2% -25.4%
From 52-week high -26.9%-46.9% -2.5%
52-week high $67.61$36.28 $779.14
52-week low $44.34$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPLEGN
P/E now vs peer median -10.6xmedian 17.2x -38.7xmedian 17.2x
P/S now vs peer median 356.5xmedian 8.8x 2.8xmedian 8.8x
EV/EBITDA now vs peer median -5.8xmedian 16.0x -164.7xmedian 16.0x
P/FCF now vs peer median -12.9xmedian 17.8x -55.0xmedian 17.8x
P/B now vs peer median 2.7xmedian 2.1x 2.9xmedian 2.1x
PEG now vs peer median -2.74median 0.32 -0.82median 0.32

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPLEGN
Revenue $13.39M $1.27B
Gross profit – $727.10M
Operating income -$534.34M -$55.25M
Net income -$451.14M -$80.39M
Free cash flow -$371.33M -$64.60M
R&D $278.15M $396.15M
EPS (diluted) $-4.67 $-0.50
Cash & equivalents $291.34M $672.90M
Total debt $586.20M $1.06B
Shares (diluted) 96.51M 184.32M
Enterprise value -$3.97B $1.26B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPLEGN
P/E -10.6x -38.7x
P/FCF -12.9x -55.0x
P/Operating cash flow -12.9x -39.7x
P/S 356.5x 2.8x
P/B 2.7x 2.9x
P/Tangible book 2.7x 2.9x
EV/EBITDA -5.8x -164.7x
EV/EBIT -5.6x -54.9x
EV/Revenue 223.7x 2.4x
EV/FCF -8.1x -47.0x
EV/Operating cash flow -8.1x -34.0x
PEG (3Y EPS CAGR) -2.74 -0.82

Growth

14 metrics
MetricCRSPLEGN
Revenue growth (1Y) -64.8% 59.5%
Revenue CAGR (3Y) -57.1% 97.6%
Gross profit growth (1Y) – 42.4%
Gross profit CAGR (3Y) – 147.5%
Operating income growth (1Y) 3.3% 75.3%
Operating income CAGR (3Y) -4.1% 49.1%
Net income growth (1Y) 3.6% 75.3%
Net income CAGR (3Y) -2.7% 46.7%
EPS growth (1Y) 13.0% 72.0%
EPS CAGR (3Y) 3.9% 47.0%
Operating cash flow growth (1Y) -13.8% 67.5%
Operating cash flow CAGR (3Y) -2.5% 37.1%
Free cash flow growth (1Y) -14.1% 77.8%
Free cash flow CAGR (3Y) -0.9% 44.5%

Profitability

14 metrics
MetricCRSPLEGN
Gross margin – 57.2%
EBITDA margin -3,850% -1.5%
Operating margin -3,990% -4.3%
Pretax margin -3,346% -4.4%
Net margin -3,369% -7.2%
FCF margin -2,773% -5.1%
Operating cash flow margin -2,760% -7.0%
Return on equity -25.3% -8.3%
Return on assets -16.8% -5.5%
Return on invested capital -22.6% -4.2%
Return on capital employed -20.9% -4.3%
Asset turnover 0.0x 0.8x
Cash conversion (OCF / net income) 0.8x 1.1x
Stock comp / revenue 510.2% 5.2%

Financial Health

11 metrics
MetricCRSPLEGN
Debt / assets 22.1% 8.9%
Debt / equity 0.3x 0.1x
Net debt / EBITDA 3.4x 28.0x
Debt / FCF -1.6x -2.4x
Liabilities / assets 34.1% 29.8%
Equity / assets 65.9% 70.2%
Interest coverage – -4.8x
Current ratio 17.8x 3.0x
Quick ratio 17.8x 1.7x
Cash ratio 17.8x 1.7x
Altman Z-score 2.38 6.26

Shareholder Returns

7 metrics
MetricCRSPLEGN
Dividend yield – –
Net buyback yield -8.9% -6.0%
Shareholder yield -8.9% -6.0%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPLEGN
EPS, next fiscal year $-4.12FY2026 $-0.04FY2026
Revenue, next fiscal year $38.73MFY2026 $1.37BFY2026
Revenue growth, next FY +1,003.4%FY2026 +32.9%FY2026
Revenue growth, the year after +259.5% +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPLEGN
Held by institutions 78.9% 55.9%
Institutions holding 518 218
Change in shares held, QoQ -1.0% +7.3%
Institutions buying 237 117
Institutions selling 139 78
Buyers to sellers 1.71 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPLEGN
CRSP 1.00 0.04
LEGN 0.04 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CRSP and LEGN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.73B, Legend Biotech (LEGN) $3.76B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Legend Biotech (LEGN) -7.2%). On return on invested capital, Legend Biotech (LEGN) leads (CRISPR Therapeutics AG (CRSP) -22.6%, Legend Biotech (LEGN) -4.2%).

Which stock has performed better?

Over the past year CRISPR Therapeutics AG (CRSP) returned the most: CRISPR Therapeutics AG (CRSP) -26.5%, Legend Biotech (LEGN) -39.2%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -12.4%/yr, Legend Biotech (LEGN) -18.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.0%, Legend Biotech (LEGN) 71.7%). Volatility measures how widely the price swings, not the risk of the business.

Do CRSP and LEGN move together?

Their daily returns over the past year have a correlation of 0.04, a weak relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, CRSP and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, CRISPR Therapeutics AG (CRSP) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.