BEAM vs MESO vs TSHA Stock Comparison

Beam Therapeutics, Mesoblast and Taysha Gene Therapies Prices as of Oct 29, 2026 Peers: Industry group
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BEAM Beam Therapeutics Inc.
$28.84 +17.6% 1M +16.4% 1Y
Market cap
$2.78B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins
MESO Mesoblast Ltd
$15.67 +5.4% 1M -4.2% 1Y
Market cap
$1.95B
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
2 wins

Head to Head

8 decided of 12

Beam Therapeutics leads on 5 of the 12 questions below (Beam Therapeutics 5, Mesoblast 2, Taysha Gene Therapies 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBEAMMESOTSHALeader
Larger companyMarket capitalisation $2.78B $1.95B $1.52B BEAM
Cheaper on earningsLower P/E, profitable companies only -32.6x -35.3x -10.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months +158.9% — -32.3% BEAM
More profitableNet margin, trailing twelve months -54.7% — -2,728.0% BEAM
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA 3.0x — 2.7x TSHA
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +16.4% -4.2% -15.8% BEAM
Better 5-year returnAnnualised price return, 5 years -20.1%/yr +5.3%/yr -23.1%/yr MESO
Less volatileAnnualised volatility, 1 year 70.4% 57.1% 71.5% MESO
Higher overall scoreMean of the five percentile scores vs peers 70/100 — 49/100 BEAM

Percentile Scorecard

BEAMMESOTSHA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBEAMMESOTSHA
Valuation 57 #269 of 624 67 #208 of 624 45 #343 of 624
Growth 77 #138 of 601 – 16 #503 of 601
Profitability 64 #193 of 541 – 28 #390 of 541
Financial Health 81 #122 of 647 44 #361 of 647 75 #160 of 647
Shareholder Returns 68 #116 of 359 – 78 #79 of 359
Overall 70 – 49
  • BEAM ranked among 671 companies in Pharmaceuticals and Biotechnology
  • MESO ranked among 671 companies in Pharmaceuticals and Biotechnology
  • TSHA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBEAMMESOTSHASPY
1 month +17.6%+5.4%-15.4% +0.7%
3 months +8.9%+7.7%-28.2% +3.7%
6 months -4.9%0.0%-34.0% +7.1%
Year to date +4.0%-13.1%-23.3% +12.8%
1 year +16.4%-4.2%-15.8% +11.9%
3 years +50.9%+531.9%+86.7% +85.2%
3 years, per year +14.7%+85.0%+23.2% +22.8%
5 years -67.5%+29.5%-73.0% +67.6%
5 years, per year -20.1%+5.3%-23.1% +10.9%
10 years —+81.4%— +262.0%
10 years, per year —+6.1%— +13.7%

Risk

MeasureBEAMMESOTSHASPY
Volatility, 1Y 70.4%57.1%71.5% 12.7%
Downside volatility, 1Y 63.6%55.0%69.5% 12.6%
Beta vs S&P 500, 1Y 2.091.481.82 1.00
Return / volatility, 1Y 0.23-0.07-0.22 0.94
Max drawdown, 5Y -85.3%-87.9%-96.5% -25.4%
From 52-week high -23.9%-25.2%-39.5% -1.2%
52-week high $37.92$20.96$6.98 $779.14
52-week low $20.60$11.95$3.51 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBEAMMESOTSHA
P/E now vs peer median -35.2xmedian 17.8x -35.3xmedian 17.8x -10.4xmedian 17.8x
P/S now vs peer median 19.1xmedian 9.1x 16.9xmedian 9.1x 250.3xmedian 9.1x
EV/EBITDA now vs peer median -5.4xmedian 15.0x —median 15.0x -6.4xmedian 15.0x
P/FCF now vs peer median -8.0xmedian 21.7x -45.4xmedian 21.7x -10.4xmedian 21.7x
P/B now vs peer median 2.8xmedian 2.2x 3.6xmedian 2.2x 3.5xmedian 2.2x
PEG now vs peer median -0.83median 0.35 —median 0.35 -0.26median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBEAMMESOTSHA
Revenue $156.04M – $5.49M
Operating income -$378.02M – -$153.16M
Net income -$86.52M – -$149.63M
Free cash flow -$372.77M – -$132.57M
R&D $408.66M – $123.14M
EPS (diluted) $-0.82 – $-0.41
Cash & equivalents $219.83M $102.91M $455.41M
Total debt $100.26M $119.24M $49.26M
Shares (diluted) 104.33M 129.49M 369.04M
Enterprise value -$1.90B $1.51B $169.50M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBEAMMESOTSHA
P/E -35.2x -35.3x -10.4x
P/FCF -8.0x -45.4x -10.4x
P/Operating cash flow -8.3x – -10.4x
P/S 19.1x 16.9x 250.3x
P/B 2.8x 3.6x 3.5x
P/Tangible book 2.8x 3.6x 3.5x
EV/EBITDA -5.4x – -6.4x
EV/EBIT -5.1x – -6.3x
EV/Revenue 12.3x – 176.2x
EV/FCF -5.2x – -7.3x
EV/Operating cash flow -5.4x – -7.3x
PEG (3Y EPS CAGR) -0.83 – -0.26

Growth

14 metrics
MetricBEAMMESOTSHA
Revenue growth (1Y) 158.9% – -32.3%
Revenue CAGR (3Y) 24.9% – -9.1%
Gross profit growth (1Y) – – –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) 15.2% – -62.9%
Operating income CAGR (3Y) 0.3% – -8.7%
Net income growth (1Y) 78.2% – -61.4%
Net income CAGR (3Y) 35.8% – -6.5%
EPS growth (1Y) 79.0% – -30.3%
EPS CAGR (3Y) 42.4% – 40.5%
Operating cash flow growth (1Y) -4.2% – -61.0%
Operating cash flow CAGR (3Y) -2.0% – -35.6%
Free cash flow growth (1Y) -4.8% – -60.6%
Free cash flow CAGR (3Y) 0.7% – -29.4%

Profitability

14 metrics
MetricBEAMMESOTSHA
Gross margin – – –
EBITDA margin -228.0% – -2,770%
Operating margin -242.3% – -2,792%
Pretax margin -54.4% – -2,593%
Net margin -54.7% – -2,728%
FCF margin -238.9% – -2,417%
Operating cash flow margin -230.3% – -2,410%
Return on equity -7.6% – -47.5%
Return on assets -5.9% – -36.9%
Return on invested capital – – –
Return on capital employed -27.9% – -42.6%
Asset turnover 0.1x – 0.0x
Cash conversion (OCF / net income) 4.2x – 0.9x
Stock comp / revenue 52.2% – 331.3%

Financial Health

11 metrics
MetricBEAMMESOTSHA
Debt / assets 7.2% 15.4% 10.5%
Debt / equity 0.1x 0.2x 0.1x
Net debt / EBITDA 3.0x – 2.7x
Debt / FCF -0.3x – -0.4x
Liabilities / assets 23.0% 26.5% 17.7%
Equity / assets 77.0% 73.5% 82.3%
Interest coverage – – -3,647x
Current ratio 14.6x 2.4x 17.8x
Quick ratio 14.3x 2.0x 17.5x
Cash ratio 14.3x 1.3x 17.5x
Altman Z-score 3.85 – 7.57

Shareholder Returns

7 metrics
MetricBEAMMESOTSHA
Dividend yield – – –
Net buyback yield -0.5% – -0.2%
Shareholder yield -0.5% – -0.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBEAMMESOTSHA
EPS, next fiscal year $-4.22FY2026 $-0.15FY2027 $-0.47FY2026
Revenue, next fiscal year $49.46MFY2026 $188.99MFY2027 $1.96MFY2026
Revenue growth, next FY -64.6%FY2026 +57.2%FY2027 -80.0%FY2026
Revenue growth, the year after +23.6% +110.3% +1,298.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBEAMMESOTSHA
Held by institutions 100.0% 3.0% 81.2%
Institutions holding 277 73 209
Change in shares held, QoQ +1.0% +17.7% +12.7%
Institutions buying 154 34 140
Institutions selling 75 20 42
Buyers to sellers 2.05 1.70 3.33

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BEAMMESOTSHA
BEAM 1.00 0.13 0.45
MESO 0.13 1.00 0.30
TSHA 0.45 0.30 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, BEAM, MESO and TSHA?

Beam Therapeutics (BEAM) is the largest by market capitalisation: Beam Therapeutics (BEAM) $2.78B, Mesoblast (MESO) $1.95B, Taysha Gene Therapies (TSHA) $1.52B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: Beam Therapeutics (BEAM) +158.9%, Taysha Gene Therapies (TSHA) -32.3%.

Which company is more profitable?

Beam Therapeutics (BEAM) has the highest net margin (Beam Therapeutics (BEAM) -54.7%, Taysha Gene Therapies (TSHA) -2,728.0%).

Which stock has performed better?

Over the past year Beam Therapeutics (BEAM) returned the most: Beam Therapeutics (BEAM) +16.4%, Mesoblast (MESO) -4.2%, Taysha Gene Therapies (TSHA) -15.8%. Over five years, Mesoblast (MESO) compounded fastest (Beam Therapeutics (BEAM) -20.1%/yr, Mesoblast (MESO) +5.3%/yr, Taysha Gene Therapies (TSHA) -23.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Mesoblast (MESO) has been the steadiest (Beam Therapeutics (BEAM) 70.4%, Mesoblast (MESO) 57.1%, Taysha Gene Therapies (TSHA) 71.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BEAM, MESO and TSHA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Beam Therapeutics (BEAM) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.