As of September 29, 2026, the three largest insider holders of XENE are Mohammad Azab (Director, 74.22K shares), Dawn Svoronos (Director, 31.37K shares), Gary Patou (Director, 24.90K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Mohammad Azab | Director | 74,225 | 0 | 74,225 | 37.6% | 20 Dec, 2023 |
| 2 | Dawn Svoronos | Director | 31,373 | 0 | 31,373 | 15.9% | 03 Sep, 2026 |
| 3 | Gary Patou | Director | 24,896 | 0 | 24,896 | 12.6% | 08 Jun, 2026 |
| 4 | Ian Mortimer | President Ceo | 19,923 | 0 | 19,923 | 10.1% | 13 Mar, 2026 |
| 5 | James R. Empfield | Evp, Drug Discovery | 10,000 | 0 | 10,000 | 5.1% | 16 Aug, 2022 |
| 6 | Sherrington Robin | Evp, Strategy Innovation | 8,398 | 0 | 8,398 | 4.3% | 08 Mar, 2024 |
| 7 | Andrea Difabio | Chief Legal Officer | 7,301 | 0 | 7,301 | 3.7% | 13 Mar, 2026 |
| 8 | Simon N. Pimstone | Ceo | 6,000 | 0 | 6,000 | 3.0% | 01 Jun, 2023 |
| 9 | Seggern Christopher Von | Chief Commercial Officer | 4,000 | 0 | 4,000 | 2.0% | 07 Dec, 2021 |
| 10 | Patrick Machado | Director | 2,645 | 0 | 2,645 | 1.3% | 03 Jun, 2026 |
| 11 | Justin D. Gover | Director | 2,645 | 0 | 2,645 | 1.3% | 03 Jun, 2026 |
| 12 | Elizabeth A. Garofalo | Director | 2,645 | 0 | 2,645 | 1.3% | 03 Jun, 2026 |
| 13 | Steven Gannon | Director | 1,870 | 0 | 1,870 | 0.9% | 13 Aug, 2026 |
| 14 | Gillian Cannon | Director | 1,455 | 0 | 1,455 | 0.7% | 08 Jun, 2026 |
| 15 | Christopher John Kenney | Chief Medical Officer | 2 | 0 | 2 | 0.0% | 31 Aug, 2026 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 01 Sep, 2026 | Dawn Svoronos | Director | Acquired M | 5,144 | $8.15 | $41.92K | 31,373 | Direct |
| 01 Sep, 2026 | Dawn Svoronos | Director | Disposed M | 5,144 | $0.00 | $0 | 0 | Direct |
| 28 Aug, 2026 | Christopher John Kenney | Chief Medical Officer | Disposed S | 6,368 | $60.17 | $383.15K | 702 | Direct |
| 28 Aug, 2026 | Christopher John Kenney | Chief Medical Officer | Disposed S | 700 | $60.98 | $42.68K | 2 | Direct |
| 11 Aug, 2026 | Steven Gannon | Director | Disposed S | 10,000 | $64.06 | $640.55K | 1,870 | Direct |
| 05 Jun, 2026 | Gillian Cannon | Director | Disposed S | 1,190 | $53.14 | $63.24K | 1,455 | Direct |
| 05 Jun, 2026 | Gary Patou | Director | Disposed S | 1,322 | $53.14 | $70.25K | 24,896 | Direct |
| 01 Jun, 2026 | Patrick Machado | Director | Acquired M | 2,645 | — | — | 2,645 | Direct |
| 01 Jun, 2026 | Elizabeth A. Garofalo | Director | Acquired M | 2,645 | — | — | 2,645 | Direct |
| 01 Jun, 2026 | Justin D. Gover | Director | Acquired M | 2,645 | — | — | 2,645 | Direct |
| 01 Jun, 2026 | Steven Gannon | Director | Acquired M | 2,645 | — | — | 13,286 | Direct |
| 01 Jun, 2026 | Dawn Svoronos | Director | Acquired M | 2,645 | — | — | 27,645 | Direct |
| 01 Jun, 2026 | Gillian Cannon | Director | Acquired M | 2,645 | — | — | 2,645 | Direct |
| 01 Jun, 2026 | Gary Patou | Director | Acquired M | 2,645 | — | — | 26,218 | Direct |
| 01 Jun, 2026 | Justin D. Gover | Director | Disposed M | 2,645 | $0.00 | $0 | 0 | Direct |
| 01 Jun, 2026 | Gillian Cannon | Director | Disposed M | 2,645 | $0.00 | $0 | 0 | Direct |
| 01 Jun, 2026 | Patrick Machado | Director | Disposed M | 2,645 | $0.00 | $0 | 0 | Direct |
| 01 Jun, 2026 | Elizabeth A. Garofalo | Director | Disposed M | 2,645 | $0.00 | $0 | 0 | Direct |
| 01 Jun, 2026 | Dawn Svoronos | Director | Disposed F | 1,416 | $53.41 | $75.63K | 26,229 | Direct |
| 01 Jun, 2026 | Steven Gannon | Director | Disposed F | 1,416 | $53.41 | $75.63K | 11,870 | Direct |