Xenon Pharmaceuticals Inc. (XENE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

79,040,000Shares Outstanding

4,386,555Shares held by institutions

$182,743,881Value of institutional holdings

105.11%Institutional ownership %

0.41%Shares Changed QoQ

236No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 236 institutions have reported a stake in Xenon Pharmaceuticals Inc. (NASDAQ:XENE) as of December 2025, according to recent 13F filings with the SEC.

The percentage of Xenon Pharmaceuticals owned by institutions changed from 107.1% in September 2025 to 105.1% in December 2025, marking a slight down trend.
On a quarter-over-quarter basis, institutional holdings shifted by 0.41%, with a year-over-year an increase of 14.01% in the count of filers.
Of these 236 institutional investors, 126 increased their holdings in Xenon Pharmaceuticals, while 71 of them reduced positions, and 39 investors maintained their exposure.
This class of investors increased its holdings in Xenon Pharmaceuticals to 83.08Mn shares for the 13F-cycle ending December 2025, up by 336.42K shares quarter on quarter, and up 6.82Mn shares year over year.
With 8.92Mn shares, FMR LLC commands the largest institutional position in Xenon Pharmaceuticals as of December 31, 2025, equating to 11.29% of the company.
Among the most significant buyers of Xenon Pharmaceuticals during December 2025 were WELLINGTON MANAGEMENT GROUP LLP (1.15Mn), Trails Edge Capital Partners, LP (597.09K), BARCLAYS PLC (489.66K), FEDERATED HERMES, INC. (439.74K), TWO SIGMA INVESTMENTS, LP (436.74K).
Leading sellers of Xenon Pharmaceuticals stock in December 2025 included BRAIDWELL LP (1.78Mn), Commodore Capital LP (900.00K), Deep Track Capital, LP (833.57K), MILLENNIUM MANAGEMENT LLC (813.95K), Holocene Advisors, LP (694.47K).
The top 10 institutional holders of Xenon Pharmaceuticals for the quarter ending December 2025 included FMR LLC (8.92Mn), Avoro Capital Advisors LLC (5.42Mn), BlackRock, Inc. (5.10Mn), WELLINGTON MANAGEMENT GROUP LLP (4.76Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (4.54Mn), JANUS HENDERSON GROUP PLC (4.08Mn), Capital International Investors (3.41Mn), Polar Capital Holdings Plc (2.47Mn), BRAIDWELL LP (1.83Mn), Commodore Capital LP (1.80Mn).

236 Institutional Holders

4,386,555 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	8,920,250	1,343	0.02%	$399,805,605.00
Avoro Capital Advisors LLC	31 Dec, 2025	5,424,444	24,444	0.45%	$243,123,580.00
BlackRock, Inc.	31 Dec, 2025	5,100,284	329,333	6.90%	$228,594,728.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	4,764,779	1,154,922	31.99%	$213,557,396.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	4,538,691	369,577	8.86%	$203,424,131.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	4,084,034	140,149	3.55%	$183,109,819.00
Capital International Investors	31 Dec, 2025	3,414,959	233,466	7.34%	$153,058,462.00
Polar Capital Holdings Plc	31 Dec, 2025	2,465,694	-81,072	-3.18%	$110,512,405.00
BRAIDWELL LP	31 Dec, 2025	1,825,076	-1,779,953	-49.37%	$81,799,906.00
Commodore Capital LP	31 Dec, 2025	1,800,000	-900,000	-33.33%	$80,676,000.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	1,593,814	-60,603	-3.66%	$71,434,743.00
JPMORGAN CHASE & CO	31 Dec, 2025	1,494,032	94,999	6.79%	$66,962,514.00
STATE STREET CORP	31 Dec, 2025	1,492,550	26,083	1.78%	$66,896,091.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,321,213	362,115	37.76%	$59,216,767.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	1,292,055	156,820	13.81%	$57,909,905.00
Holocene Advisors, LP	31 Dec, 2025	1,282,081	-694,472	-35.14%	$57,462,870.00
Affinity Asset Advisors, LLC	31 Dec, 2025	1,250,000	-150,000	-10.71%	$56,025,000.00
WESTFIELD CAPITAL MANAGEMENT CO LP	31 Dec, 2025	1,226,771	20,705	1.72%	$54,983,876.00
BNP Paribas Asset Management Holding S.A.	31 Dec, 2025	1,060,221	389,964	58.18%	$47,519.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	952,679	-24,756	-2.53%	$42,692,208.00

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