Xenon Pharmaceuticals Inc. (XENE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

77,105,799Shares Outstanding

13,354,568Shares held by institutions

$588,402,266Value of institutional holdings

109.78%Institutional ownership %

1.96%Shares Changed QoQ

218No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Xenon Pharmaceuticals Inc. (NASDAQ:XENE) includes 218 filers as of the latest reporting cycle ending September 2025.

The collective stake of institutional investors in Xenon Pharmaceuticals moved to 109.8% in September 2025, a shift up from the 108.7% reported for June 2025.
Quarterly data indicates a 1.96% shift in institutional share volume, and the annual owner count reflects an increase of 7.92%.
The latest 13F cycle for Xenon Pharmaceuticals reveals that of 218 total investors, 97 funds grew their exposure, whereas 80 reduced theirs and 41 made no changes.
Collectively, institutional investors increased their stake in Xenon Pharmaceuticals to 84.64Mn shares as of September 2025, a change that is up by 1.63Mn shares quarter on quarter and up 9.91Mn shares year over year.
FMR LLC continues to be the largest institutional holder of Xenon Pharmaceuticals as of September 30, 2025, with a position of 8.92Mn shares, representing 11.57% of the company's outstanding stock.
Among the most significant buyers of Xenon Pharmaceuticals during September 2025 were WELLINGTON MANAGEMENT GROUP LLP (1.44Mn), MILLENNIUM MANAGEMENT LLC (566.17K), T. Rowe Price Investment Management, Inc. (522.17K), Caligan Partners LP (444.56K), JENNISON ASSOCIATES LLC (438.85K).
Leading sellers of Xenon Pharmaceuticals stock in September 2025 included Vestal Point Capital, LP (900.00K), BlackRock, Inc. (594.38K), ORBIMED ADVISORS LLC (528.28K), ADAGE CAPITAL PARTNERS GP, L.L.C. (455.00K), MARSHALL WACE, LLP (408.27K).
The top 10 institutional holders of Xenon Pharmaceuticals for the quarter ending September 2025 included FMR LLC (8.92Mn), Avoro Capital Advisors LLC (5.40Mn), BlackRock, Inc. (4.77Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (4.17Mn), JANUS HENDERSON GROUP PLC (3.94Mn), WELLINGTON MANAGEMENT GROUP LLP (3.61Mn), BRAIDWELL LP (3.61Mn), Capital International Investors (3.18Mn), Commodore Capital LP (2.70Mn), Polar Capital Holdings Plc (2.55Mn).

218 Institutional Holders

13,354,568 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	30 Sep, 2025	8,918,907	34,544	0.39%	$358,094,116.00
Avoro Capital Advisors LLC	30 Sep, 2025	5,400,000	0	0.00%	$216,810,000.00
BlackRock, Inc.	30 Sep, 2025	4,770,951	-594,376	-11.08%	$191,553,697.00
DRIEHAUS CAPITAL MANAGEMENT LLC	30 Sep, 2025	4,169,114	-166,534	-3.84%	$167,389,927.00
JANUS HENDERSON GROUP PLC	30 Sep, 2025	3,943,885	366,150	10.23%	$158,311,659.00
WELLINGTON MANAGEMENT GROUP LLP	30 Sep, 2025	3,609,857	1,435,096	65.99%	$144,935,758.00
BRAIDWELL LP	30 Sep, 2025	3,605,029	0	0.00%	$144,741,914.00
Capital International Investors	30 Sep, 2025	3,181,493	-56	0.00%	$127,736,944.00
Commodore Capital LP	30 Sep, 2025	2,700,000	-325,000	-10.74%	$108,405,000.00
Polar Capital Holdings Plc	30 Sep, 2025	2,546,766	-156,490	-5.79%	$102,252,655.00
Holocene Advisors, LP	30 Sep, 2025	1,976,553	167,078	9.23%	$79,358,603.00
ALLIANCEBERNSTEIN L.P.	30 Sep, 2025	1,654,417	135,890	8.95%	$66,424,843.00
STATE STREET CORP	30 Sep, 2025	1,466,467	86,007	6.23%	$58,878,650.00
MILLENNIUM MANAGEMENT LLC	30 Sep, 2025	1,449,007	566,172	64.13%	$58,177,631.00
Affinity Asset Advisors, LLC	30 Sep, 2025	1,400,000	300,000	27.27%	$56,210,000.00
JPMORGAN CHASE & CO	30 Sep, 2025	1,399,033	142,452	11.34%	$56,171,175.00
Pictet Asset Management Holding SA	30 Sep, 2025	1,262,579	-211,870	-14.37%	$50,584,462.00
WESTFIELD CAPITAL MANAGEMENT CO LP	30 Sep, 2025	1,206,066	53,461	4.64%	$48,423,550.00
Deep Track Capital, LP	30 Sep, 2025	1,200,000	-150,000	-11.11%	$48,180,000.00
JENNISON ASSOCIATES LLC	30 Sep, 2025	1,135,235	438,852	63.02%	$45,579,686.00

1 - 20 of 218

Xenon Pharmaceuticals Inc. (XENE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

218 Institutional Holders

Create an account

Sign In

Reset Password

Get Pro for 60% off