Xenon Pharmaceuticals Inc. (XENE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

79,247,976Shares Outstanding

89,830,748Shares held by institutions

$5,246,115,683Value of institutional holdings

113.35%Institutional ownership %

6.57%Shares Changed QoQ

239No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Xenon Pharmaceuticals Inc. (NASDAQ:XENE) has 239 institutional investors with active 13F positions as of December 2025.

Their combined ownership stood at 105.6% of outstanding shares in December 2025, down from 108.6% in September 2025.
They decreased total shares held in Xenon Pharmaceuticals by -0.54% from last quarter, and the number of investors in XENE increased 15.46% annually.
Of these 239 holders, 130 added to their stakes in Xenon Pharmaceuticals, 72 trimmed positions, and 37 made no changes.
Institutional investors collectively held 83.71Mn shares in Xenon Pharmaceuticals as of December 2025, down by 453.32K shares quarter on quarter, and up 7.0Mn shares year over year.
Avoro Capital Advisors LLC leads ownership in XENE with 10.85Mn shares as of December 31, 2025, equal to 13.69% of outstanding shares.
The largest buyers of Xenon Pharmaceuticals for the quarter ending December 2025 were Avoro Capital Advisors LLC (5.45Mn), WELLINGTON MANAGEMENT GROUP LLP (1.15Mn), Goldman Sachs Group Inc (671.44K), Trails Edge Capital Partners, LP (597.09K), Federated Hermes, Inc. (439.74K).
The largest sellers of Xenon Pharmaceuticals for the quarter ending December 2025 were BRAIDWELL LP (1.78Mn), Jpmorgan Chase & Co (1.3Mn), Commodore Capital LP (900.0K), Deep Track Capital, LP (833.56K), MILLENNIUM MANAGEMENT LLC (748.95K).
Xenon Pharmaceuticals's 10 largest shareholders as of December 2025 include Avoro Capital Advisors LLC (10.85Mn), FMR LLC (8.92Mn), BlackRock, Inc. (5.1Mn), WELLINGTON MANAGEMENT GROUP LLP (4.76Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (4.54Mn), Janus Henderson Group Plc (4.08Mn), Capital International Investors (3.41Mn), Polar Capital Holdings Plc (2.47Mn), BRAIDWELL LP (1.83Mn), Commodore Capital LP (1.8Mn) per Business Quant data.

239 Institutional Holders

89,830,748 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Avoro Capital Advisors LLC	31 Dec, 2025	10,848,888	5,448,888	100.91%	$486,247,160.00
FMR LLC	31 Dec, 2025	8,920,250	1,343	0.02%	$399,805,605.00
BlackRock, Inc.	31 Dec, 2025	5,100,284	329,333	6.90%	$228,594,728.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	4,764,779	1,154,922	31.99%	$213,557,396.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	4,538,691	369,577	8.86%	$203,424,131.00
Janus Henderson Group Plc	31 Dec, 2025	4,084,034	140,149	3.55%	$183,109,819.00
Capital International Investors	31 Dec, 2025	3,414,959	233,466	7.34%	$153,058,462.00
Polar Capital Holdings Plc	31 Dec, 2025	2,465,694	-81,072	-3.18%	$110,512,405.00
BRAIDWELL LP	31 Dec, 2025	1,825,076	-1,779,953	-49.37%	$81,799,906.00
Commodore Capital LP	31 Dec, 2025	1,800,000	-900,000	-33.33%	$80,676,000.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	1,593,814	-60,603	-3.66%	$71,434,743.00
Jpmorgan Chase & Co	31 Dec, 2025	1,494,032	-1,304,034	-46.60%	$66,962,514.00
State Street Corp	31 Dec, 2025	1,492,550	26,083	1.78%	$66,896,091.00
Goldman Sachs Group Inc	31 Dec, 2025	1,392,094	671,435	93.17%	$62,393,652.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,321,213	362,115	37.76%	$59,216,767.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	1,292,055	156,820	13.81%	$57,909,905.00
Holocene Advisors, LP	31 Dec, 2025	1,282,081	-694,472	-35.14%	$57,462,870.00
Affinity Asset Advisors, LLC	31 Dec, 2025	1,250,000	-150,000	-10.71%	$56,025,000.00
WESTFIELD CAPITAL MANAGEMENT CO LP	31 Dec, 2025	1,226,771	20,705	1.72%	$54,983,876.00
BNP Paribas Asset Management Holding S.A.	31 Dec, 2025	1,060,221	389,964	58.18%	$47,519.00

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