Xenon Pharmaceuticals Inc. (XENE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

1,168,262Shares held by institutions

$64,791,811Value of institutional holdings

117.44%Institutional ownership %

19.89%Shares Changed QoQ

203No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Xenon Pharmaceuticals Inc. (NASDAQ:XENE) appears in 239 institutional 13F filings for the quarter ending December 2025.

They owned 105.6% of outstanding stock in December 2025, down from 108.6% the prior quarter.
Their total shares held in XENE decreased -0.54% from the prior quarter, while the number of investors in Xenon Pharmaceuticals increased 15.46% year over year.
During the quarter, 130 of these 239 funds increased positions in XENE, 72 reduced exposure, and 37 held steady.
In total, institutional investors held 83.71Mn shares in Xenon Pharmaceuticals as of December 2025, down by 453.32K shares quarter on quarter, and up 7.0Mn shares year over year.
FMR LLC holds the largest position in XENE at 8.92Mn shares as of December 31, 2025, or 11.26% of shares outstanding.
The biggest buyers of Xenon Pharmaceuticals for the quarter ending December 2025 included WELLINGTON MANAGEMENT GROUP LLP (1.15Mn), Trails Edge Capital Partners, LP (597.09K), Barclays Plc (489.66K), Federated Hermes, Inc. (439.74K), TWO SIGMA INVESTMENTS, LP (436.74K).
Leading sellers of Xenon Pharmaceuticals shares for the quarter ending December 2025 were BRAIDWELL LP (1.78Mn), Jpmorgan Chase & Co (1.3Mn), Commodore Capital LP (900.0K), Deep Track Capital, LP (833.56K), MILLENNIUM MANAGEMENT LLC (748.95K).
Per Business Quant data, the top 10 holders of Xenon Pharmaceuticals for the quarter ending December 2025 are FMR LLC (8.92Mn), Avoro Capital Advisors LLC (5.42Mn), BlackRock, Inc. (5.1Mn), WELLINGTON MANAGEMENT GROUP LLP (4.76Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (4.54Mn), Janus Henderson Group Plc (4.08Mn), Capital International Investors (3.41Mn), Polar Capital Holdings Plc (2.47Mn), BRAIDWELL LP (1.83Mn), Commodore Capital LP (1.8Mn).

239 Institutional Holders

1,168,262 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	329,333	6.90%	$0.00
FMR LLC	31 Dec, 2025	1,343	0.02%	$0.00
Avoro Capital Advisors LLC	31 Dec, 2025	5,448,888	100.91%	$0.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	1,154,922	31.99%	$0.00
Polar Capital Holdings Plc	31 Dec, 2025	-81,072	-3.18%	$0.00
Barclays Plc	31 Dec, 2025	474,671	375.85%	$0.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	369,577	8.86%	$0.00
BRAIDWELL LP	31 Dec, 2025	-1,779,953	-49.37%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	2,000	1,000.00%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	140,149	3.55%	$0.00
Commodore Capital LP	31 Dec, 2025	-900,000	-33.33%	$0.00
Capital International Investors	31 Dec, 2025	233,466	7.34%	$0.00
Holocene Advisors, LP	31 Dec, 2025	-694,472	-35.14%	$0.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	-60,603	-3.66%	$0.00
Affinity Asset Advisors, LLC	31 Dec, 2025	-150,000	-10.71%	$0.00
Jpmorgan Chase & Co	31 Dec, 2025	-1,304,034	-46.60%	$0.00
Siren, L.L.C.	31 Dec, 2025	0	0.00%	$0.00
State Street Corp	31 Dec, 2025	26,083	1.78%	$0.00
First Turn Management, LLC	31 Dec, 2025	0	0.00%	$0.00
CITADEL ADVISORS LLC	31 Dec, 2025	362,115	37.76%	$0.00

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