Sera Prognostics, Inc. (SERA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

48,837,500Shares Outstanding

10,220,434Shares held by institutions

$26,470,924Value of institutional holdings

35.89%Institutional ownership %

-0.15%Shares Changed QoQ

55No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 55 institutional investors hold a position in Sera Prognostics, Inc. (NASDAQ:SERA).

The percentage of Sera Prognostics owned by institutions changed from 37.2% in September 2025 to 35.9% in December 2025, marking a slight down trend.
Institutional share ownership changed by -0.15% QoQ, while the number of institutional owners saw a decrease of 27.63% YoY.
The latest 13F cycle for Sera Prognostics reveals that of 55 total investors, 19 funds grew their exposure, whereas 14 reduced theirs and 22 made no changes.
The aggregate institutional position in Sera Prognostics now stands at 17.53Mn shares as of December 2025, after investors decreased their holdings (down by 26.86K shares quarter on quarter which is down 573.94K shares year over year).
As of December 31, 2025, BAKER BROS. ADVISORS LP held Sera Prognostics's largest shareholding position with over 5.50Mn shares, representing 11.26% of total outstanding shares.
Among the most significant buyers of Sera Prognostics during December 2025 were JANE STREET GROUP, LLC (68.83K), CITADEL ADVISORS LLC (53.87K), SUSQUEHANNA INTERNATIONAL GROUP, LLP (49.16K), GSA CAPITAL PARTNERS LLP (42.05K), BARCLAYS PLC (26.73K).
Leading sellers of Sera Prognostics stock in December 2025 included Whetstone Capital Advisors, LLC (172.66K), CAPTRUST FINANCIAL ADVISORS (65.57K), Squarepoint Ops LLC (56.74K), GOLDMAN SACHS GROUP INC (26.24K), MILLENNIUM MANAGEMENT LLC (14.11K).
The top 10 institutional holders of Sera Prognostics for the quarter ending December 2025 included BAKER BROS. ADVISORS LP (5.50Mn), Whetstone Capital Advisors, LLC (3.46Mn), Aberdeen Group plc (2.28Mn), Vivo Capital, LLC (1.65Mn), VANGUARD GROUP INC (1.24Mn), CITADEL ADVISORS LLC (707.61K), CAPTRUST FINANCIAL ADVISORS (536.77K), GEODE CAPITAL MANAGEMENT, LLC (334.64K), AWM Investment Company, Inc. (207.38K), BlackRock, Inc. (186.75K).

55 Institutional Holders

10,220,434 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BAKER BROS. ADVISORS LP	31 Dec, 2025	5,498,170	0	0.00%	$16,219,602.00
Whetstone Capital Advisors, LLC	31 Dec, 2025	3,459,713	-172,658	-4.75%	$10,206,153.00
Aberdeen Group plc	31 Dec, 2025	2,279,699	0	0.00%	$6,725,112.00
Vivo Capital, LLC	31 Dec, 2025	1,650,440	0	0.00%	$4,868,798.00
VANGUARD GROUP INC	31 Dec, 2025	1,239,449	22,259	1.83%	$3,656,375.00
CITADEL ADVISORS LLC	31 Dec, 2025	707,614	53,868	8.24%	$2,087,462.00
CAPTRUST FINANCIAL ADVISORS	31 Dec, 2025	536,766	-65,570	-10.89%	$1,583,460.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	334,639	3,524	1.06%	$987,474.00
AWM Investment Company, Inc.	31 Dec, 2025	207,382	0	0.00%	$611,777.00
BlackRock, Inc.	31 Dec, 2025	186,751	7,774	4.34%	$550,915.00
STATE STREET CORP	31 Dec, 2025	124,792	0	0.00%	$368,136.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	113,178	-14,109	-11.08%	$333,875.00
GSA CAPITAL PARTNERS LLP	31 Dec, 2025	107,235	42,045	64.50%	$316.00
NORTHERN TRUST CORP	31 Dec, 2025	96,535	8,052	9.10%	$284,778.00
MORGAN STANLEY	31 Dec, 2025	80,968	-3,046	-3.63%	$238,856.00
Bank of New York Mellon Corp	31 Dec, 2025	75,267	0	0.00%	$222,038.00
Perigon Wealth Management, LLC	31 Dec, 2025	72,685	0	0.00%	$214,421.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	71,532	49,160	219.74%	$211,019.00
JANE STREET GROUP, LLC	31 Dec, 2025	68,826	68,826	0.00%	$203,037.00
Requisite Capital Management, LLC	31 Dec, 2025	55,648	0	0.00%	$164,162.00

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