Rhythm Pharmaceuticals, Inc. (RYTM) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

8,725,271Shares held by institutions

$674,812,459Value of institutional holdings

106.05%Institutional ownership %

-2.91%Shares Changed QoQ

227No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) showed up in the 13F filings of 271 institutional investors as of December 2025.

Their combined ownership stood at 108.5% of outstanding shares in December 2025, down from 738.0% in September 2025.
They decreased total shares held in Rhythm Pharmaceuticals by -85.19% from the prior quarter, while the number of investors in RYTM increased 33.5% year over year.
Among the 271 funds, 155 bought more Rhythm Pharmaceuticals shares, 90 sold down, and 26 held their ground.
Combined, these investors held 71.88Mn shares in RYTM for December 2025, down by 413.61Mn shares quarter on quarter, and up 6.14Mn shares year over year.
RA CAPITAL MANAGEMENT, L.P. is the top holder of Rhythm Pharmaceuticals as of December 31, 2025, with 6.67Mn shares representing 10.06% of outstanding stock.
The biggest buyers of Rhythm Pharmaceuticals for the quarter ending December 2025 included VANGUARD GROUP INC (1.21Mn), RA CAPITAL MANAGEMENT, L.P. (985.48K), JENNISON ASSOCIATES LLC (507.02K), Rockefeller Capital Management L.P. (444.03K), Point72 Asset Management, L.P. (429.42K).
The largest sales of RYTM for the quarter ending December 2025 came from PERCEPTIVE ADVISORS LLC (416.56Mn), Jpmorgan Chase & Co (952.15K), PRIMECAP MANAGEMENT CO/CA/ (784.19K), FMR LLC (438.87K), VOLORIDGE INVESTMENT MANAGEMENT, LLC (307.69K).
Per Business Quant, the top 10 investors in RYTM for the quarter ending December 2025 include RA CAPITAL MANAGEMENT, L.P. (6.67Mn), BlackRock, Inc. (6.3Mn), VANGUARD GROUP INC (6.21Mn), BAKER BROS. ADVISORS LP (5.6Mn), PRIMECAP MANAGEMENT CO/CA/ (3.48Mn), NEA Management Company, LLC (2.91Mn), PERCEPTIVE ADVISORS LLC (2.55Mn), State Street Corp (2.2Mn), Goldman Sachs Group Inc (1.83Mn), FMR LLC (1.71Mn).

271 Institutional Holders

8,725,271 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	-4,881	-0.08%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	985,478	17.35%	$0.00
Polar Capital Holdings Plc	31 Dec, 2025	-59,540	-4.78%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	455,800	5,139.83%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	1,214,489	24.31%	$0.00
Checkpoint Capital L.P.	31 Dec, 2025	228,493	29.92%	$0.00
Barclays Plc	31 Dec, 2025	-117,346	-47.17%	$0.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	0	0.00%	$0.00
Woodline Partners LP	31 Dec, 2025	108,596	18.72%	$0.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	-784,190	-18.40%	$0.00
Pictet Asset Management Holding SA	31 Dec, 2025	-68,354	-10.01%	$0.00
NEA Management Company, LLC	31 Dec, 2025	0	0.00%	$0.00
Siren, L.L.C.	31 Dec, 2025	0	0.00%	$0.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	-416,558,578	-99.39%	$0.00
Integral Health Asset Management, LLC	31 Dec, 2025	255,000	115.91%	$0.00
State Street Corp	31 Dec, 2025	169,964	8.38%	$0.00
Goldman Sachs Group Inc	31 Dec, 2025	-62,797	-3.32%	$0.00
Point72 Asset Management, L.P.	31 Dec, 2025	429,420	0.00%	$0.00
FMR LLC	31 Dec, 2025	-438,866	-20.46%	$0.00
UBS Group AG	31 Dec, 2025	6,900	1.64%	$0.00

1 - 20 of 271

Research Tools