Rhythm Pharmaceuticals, Inc. (RYTM) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

66,193,902Shares Outstanding

9,163,911Shares held by institutions

$939,575,795Value of institutional holdings

108.07%Institutional ownership %

-85.22%Shares Changed QoQ

268No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) is held by 268 institutional firms.

Rhythm Pharmaceuticals saw its institutional ownership percentage fell to 108.1% in December 2025 from 736.8% in September 2025.
The company experienced a -85.22% quarterly change in institutional shares held, alongside an increase of 31.37% in total owners annually.
A review of institutional activity for Rhythm Pharmaceuticals shows 155 of 268 filers increasing their positions, while 87 reduced their stake, and 26 remained unchanged.
This class of investors decreased its holdings in Rhythm Pharmaceuticals to 71.54Mn shares for the 13F-cycle ending December 2025, down by 412.52Mn shares quarter on quarter, and up 6.56Mn shares year over year.
RA CAPITAL MANAGEMENT, L.P. continues to be the largest institutional holder of Rhythm Pharmaceuticals as of December 31, 2025, with a position of 6.67Mn shares, representing 10.07% of the company's outstanding stock.
Among the most significant buyers of Rhythm Pharmaceuticals during December 2025 were VANGUARD GROUP INC (1.21Mn), RA CAPITAL MANAGEMENT, L.P. (985.48K), JENNISON ASSOCIATES LLC (507.02K), Rockefeller Capital Management L.P. (444.03K), Point72 Asset Management, L.P. (429.42K).
Leading sellers of Rhythm Pharmaceuticals stock in December 2025 included PERCEPTIVE ADVISORS LLC (416.56Mn), PRIMECAP MANAGEMENT CO/CA/ (784.19K), FMR LLC (438.87K), VOLORIDGE INVESTMENT MANAGEMENT, LLC (307.69K), BALYASNY ASSET MANAGEMENT L.P. (277.73K).
The top 10 institutional holders of Rhythm Pharmaceuticals for the quarter ending December 2025 included RA CAPITAL MANAGEMENT, L.P. (6.67Mn), BlackRock, Inc. (6.30Mn), VANGUARD GROUP INC (6.21Mn), BAKER BROS. ADVISORS LP (5.60Mn), PRIMECAP MANAGEMENT CO/CA/ (3.48Mn), NEA Management Company, LLC (2.91Mn), PERCEPTIVE ADVISORS LLC (2.55Mn), STATE STREET CORP (2.20Mn), GOLDMAN SACHS GROUP INC (1.83Mn), FMR LLC (1.71Mn).

268 Institutional Holders

9,163,911 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	6,666,837	985,478	17.35%	$713,618,232.00
BlackRock, Inc.	31 Dec, 2025	6,297,334	-4,881	-0.08%	$674,066,632.00
VANGUARD GROUP INC	31 Dec, 2025	6,210,916	1,214,489	24.31%	$664,816,448.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	5,604,483	0	0.00%	$599,903,860.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	3,478,669	-784,190	-18.40%	$372,356,730.00
NEA Management Company, LLC	31 Dec, 2025	2,909,956	0	0.00%	$311,481,690.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	2,546,391	-416,558,578	-99.39%	$272,565,693.00
STATE STREET CORP	31 Dec, 2025	2,198,615	169,964	8.38%	$235,339,750.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	1,830,866	-62,797	-3.32%	$195,975,896.00
FMR LLC	31 Dec, 2025	1,706,317	-438,866	-20.46%	$182,644,125.00
FEDERATED HERMES, INC.	31 Dec, 2025	1,623,841	-104,044	-6.02%	$173,815,940.00
JPMORGAN CHASE & CO	31 Dec, 2025	1,423,989	235,920	19.86%	$152,423,883.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,375,729	12,900	0.95%	$147,282,636.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,285,222	-98,553	-7.12%	$137,570,163.00
WESTFIELD CAPITAL MANAGEMENT CO LP	31 Dec, 2025	1,267,158	198,154	18.54%	$135,636,592.00
Polar Capital Holdings Plc	31 Dec, 2025	1,185,392	-59,540	-4.78%	$126,884,360.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	1,126,125	-34,762	-2.99%	$120,591,241.00
Checkpoint Capital L.P.	31 Dec, 2025	992,200	228,493	29.92%	$106,205,088.00
Capital Research Global Investors	31 Dec, 2025	985,086	386,839	64.66%	$105,443,605.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	930,233	-49,449	-5.05%	$99,572,140.00

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