Rhythm Pharmaceuticals, Inc. (RYTM) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

66,261,055Shares Outstanding

74,050,176Shares held by institutions

$6,029,165,330Value of institutional holdings

111.76%Institutional ownership %

-84.76%Shares Changed QoQ

271No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) is held by 271 institutional investors per 13F filings through December 2025.

They owned 108.5% of outstanding stock in December 2025, down from 738.0% the prior quarter.
They decreased total shares held in Rhythm Pharmaceuticals by -85.19% from last quarter, and the number of investors in RYTM increased 33.5% annually.
Activity in RYTM broke down as 155 buyers, 90 sellers, and 26 unchanged among 271 total holders.
The aggregate institutional position in Rhythm Pharmaceuticals amounted to 71.88Mn shares as of December 2025, down by 413.61Mn shares quarter on quarter, and up 6.14Mn shares year over year.
Pictet Asset Management Holding SA leads ownership in RYTM with 667.05K shares as of December 31, 2025, equal to 1.01% of outstanding shares.
The biggest buyers of Rhythm Pharmaceuticals for the quarter ending December 2025 included Pictet Asset Management Holding SA (52.38K), STRS OHIO (16.91K), SG Americas Securities, LLC (7.02K), E Fund Management Co., Ltd. (6.45K), WEDGE CAPITAL MANAGEMENT L L P/NC (5.29K).
Top sellers of RYTM stock for the quarter ending December 2025 included E. Ohman J:or Asset Management AB (2.18K), GAMMA Investing LLC (94), Root Financial Partners, LLC (12), SIGNATUREFD, LLC (8), Sterling Capital Management LLC (1).
Per Business Quant, the top 10 investors in RYTM for the quarter ending December 2025 include Pictet Asset Management Holding SA (667.05K), STRS OHIO (28.91K), WEDGE CAPITAL MANAGEMENT L L P/NC (24.54K), SG Americas Securities, LLC (18.76K), TOTH FINANCIAL ADVISORY CORP (10.0K), EXCHANGE TRADED CONCEPTS, LLC (8.46K), E Fund Management Co., Ltd. (6.45K), Avior Wealth Management, LLC (4.65K), E. Ohman J:or Asset Management AB (4.41K), CORNERSTONE PARTNERS CAPITAL MANAGEMENT, LLC (2.46K).

271 Institutional Holders

74,050,176 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	6,666,837	985,478	17.35%	$713,618,232.00
BlackRock, Inc.	31 Dec, 2025	6,297,334	-4,881	-0.08%	$674,066,632.00
VANGUARD GROUP INC	31 Dec, 2025	6,210,916	1,214,489	24.31%	$664,816,448.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	5,604,483	0	0.00%	$599,903,860.00
Goldman Sachs Group Inc	31 Dec, 2025	3,661,732	1,768,069	93.37%	$391,951,792.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	3,478,669	-784,190	-18.40%	$372,356,730.00
NEA Management Company, LLC	31 Dec, 2025	2,909,956	0	0.00%	$311,481,690.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	2,546,391	-416,558,578	-99.39%	$272,565,693.00
State Street Corp	31 Dec, 2025	2,198,615	169,964	8.38%	$235,339,750.00
FMR LLC	31 Dec, 2025	1,706,317	-438,866	-20.46%	$182,644,125.00
Federated Hermes, Inc.	31 Dec, 2025	1,623,841	-104,044	-6.02%	$173,815,940.00
Jpmorgan Chase & Co	31 Dec, 2025	1,423,989	-952,149	-40.07%	$152,423,883.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,375,729	12,900	0.95%	$147,282,636.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,285,222	-98,553	-7.12%	$137,570,163.00
WESTFIELD CAPITAL MANAGEMENT CO LP	31 Dec, 2025	1,267,158	198,154	18.54%	$135,636,592.00
Polar Capital Holdings Plc	31 Dec, 2025	1,185,392	-59,540	-4.78%	$126,884,360.00
Janus Henderson Group Plc	31 Dec, 2025	1,126,125	-34,762	-2.99%	$120,591,241.00
Checkpoint Capital L.P.	31 Dec, 2025	992,200	228,493	29.92%	$106,205,088.00
Capital Research Global Investors	31 Dec, 2025	985,086	386,839	64.66%	$105,443,605.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	930,233	-49,449	-5.05%	$99,572,140.00

1 - 20 of 271

Research Tools