Rhythm Pharmaceuticals, Inc. (RYTM) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

66,420,091Shares Outstanding

9,671,984Shares held by institutions

$1,098,350,503Value of institutional holdings

734.33%Institutional ownership %

630.71%Shares Changed QoQ

264No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of September 2025 show that 264 institutional investors hold a position in Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM).

These investors collectively held 734.3% of the company's total shares outstanding in September 2025, up from 105.0% in June 2025.
The company experienced a 630.71% quarterly change in institutional shares held, alongside an increase of 49.15% in total owners annually.
Among the 264 institutional holders of Rhythm Pharmaceuticals, 143 added to their stakes while 95 trimmed their positions and 26 held steady.
Collectively, institutional investors increased their stake in Rhythm Pharmaceuticals to 487.74Mn shares as of September 2025, a change that is up by 420.99Mn shares quarter on quarter and up 419.26Mn shares year over year.
The top institutional stake in Rhythm Pharmaceuticals as of September 30, 2025 belongs to PERCEPTIVE ADVISORS LLC, which owns 419.10Mn shares, or 630.99% of the company.
Among the most significant buyers of Rhythm Pharmaceuticals during September 2025 were PERCEPTIVE ADVISORS LLC (416.69Mn), VANGUARD GROUP INC (1.41Mn), ALLIANCEBERNSTEIN L.P. (918.21K), Capital Research Global Investors (598.25K), JENNISON ASSOCIATES LLC (411.55K).
Leading sellers of Rhythm Pharmaceuticals stock in September 2025 included PRIMECAP MANAGEMENT CO/CA/ (615.18K), WESTFIELD CAPITAL MANAGEMENT CO LP (560.46K), Sofinnova Investments, Inc. (339.04K), Hood River Capital Management LLC (307.85K), Checkpoint Capital L.P. (296.29K).
The top 10 institutional holders of Rhythm Pharmaceuticals for the quarter ending September 2025 included PERCEPTIVE ADVISORS LLC (419.10Mn), BlackRock, Inc. (6.30Mn), RA CAPITAL MANAGEMENT, L.P. (5.68Mn), BAKER BROS. ADVISORS LP (5.60Mn), VANGUARD GROUP INC (5.00Mn), PRIMECAP MANAGEMENT CO/CA/ (4.26Mn), NEA Management Company, LLC (2.91Mn), FMR LLC (2.15Mn), STATE STREET CORP (2.03Mn), GOLDMAN SACHS GROUP INC (1.89Mn).

264 Institutional Holders

9,671,984 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
PERCEPTIVE ADVISORS LLC	30 Sep, 2025	419,104,969	416,686,670	17,230.57%	$288,390,578.00
BlackRock, Inc.	30 Sep, 2025	6,302,215	34,677	0.55%	$636,460,694.00
RA CAPITAL MANAGEMENT, L.P.	30 Sep, 2025	5,681,359	120,000	2.16%	$573,760,445.00
BAKER BROS. ADVISORS LP	30 Sep, 2025	5,604,483	0	0.00%	$565,996,738.00
VANGUARD GROUP INC	30 Sep, 2025	4,996,427	1,407,313	39.21%	$504,589,163.00
PRIMECAP MANAGEMENT CO/CA/	30 Sep, 2025	4,262,859	-615,178	-12.61%	$430,506,130.00
NEA Management Company, LLC	30 Sep, 2025	2,909,956	0	0.00%	$293,876,456.00
FMR LLC	30 Sep, 2025	2,145,183	191,742	9.82%	$216,642,009.00
STATE STREET CORP	30 Sep, 2025	2,028,651	121,050	6.35%	$204,873,464.00
GOLDMAN SACHS GROUP INC	30 Sep, 2025	1,893,663	159,941	9.23%	$191,241,026.00
FEDERATED HERMES, INC.	30 Sep, 2025	1,727,885	41,391	2.45%	$174,499,106.00
PRICE T ROWE ASSOCIATES INC /MD/	30 Sep, 2025	1,399,897	58,505	4.36%	$141,377.00
DRIEHAUS CAPITAL MANAGEMENT LLC	30 Sep, 2025	1,383,775	113,823	8.96%	$139,747,437.00
GEODE CAPITAL MANAGEMENT, LLC	30 Sep, 2025	1,362,829	51,576	3.93%	$137,654,057.00
Polar Capital Holdings Plc	30 Sep, 2025	1,244,932	-5,938	-0.47%	$125,725,683.00
JPMORGAN CHASE & CO	30 Sep, 2025	1,188,069	404,510	51.62%	$119,983,088.00
JANUS HENDERSON GROUP PLC	30 Sep, 2025	1,160,887	-251,015	-17.78%	$117,237,978.00
WESTFIELD CAPITAL MANAGEMENT CO LP	30 Sep, 2025	1,069,004	-560,464	-34.40%	$107,958,714.00
ALKEON CAPITAL MANAGEMENT LLC	30 Sep, 2025	1,017,700	0	0.00%	$102,777,523.00
ALLIANCEBERNSTEIN L.P.	30 Sep, 2025	979,682	918,212	1,493.76%	$98,938,085.00

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Rhythm Pharmaceuticals, Inc. (RYTM) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

264 Institutional Holders

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