Rhythm Pharmaceuticals, Inc. (RYTM) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

66,261,055Shares Outstanding

73,720,176Shares held by institutions

$6,466,733,839Value of institutional holdings

111.26%Institutional ownership %

-84.82%Shares Changed QoQ

271No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) has 271 institutional investors that have filed 13F reports for the period ending December 2025.

Collectively, these holders controlled 108.5% of Rhythm Pharmaceuticals's outstanding shares in December 2025, down from 738.0% in September 2025.
Their total shares held in RYTM decreased -85.19% from the prior quarter, while the number of investors in Rhythm Pharmaceuticals increased 33.5% year over year.
During the quarter, 155 of these 271 funds increased positions in RYTM, 90 reduced exposure, and 26 held steady.
Institutional investors collectively held 71.88Mn shares in Rhythm Pharmaceuticals as of December 2025, down by 413.61Mn shares quarter on quarter, and up 6.14Mn shares year over year.
RA CAPITAL MANAGEMENT, L.P. leads ownership in RYTM with 6.67Mn shares as of December 31, 2025, equal to 10.06% of outstanding shares.
The biggest buyers of Rhythm Pharmaceuticals for the quarter ending December 2025 included Goldman Sachs Group Inc (1.77Mn), VANGUARD GROUP INC (1.21Mn), RA CAPITAL MANAGEMENT, L.P. (985.48K), JENNISON ASSOCIATES LLC (507.02K), Rockefeller Capital Management L.P. (455.8K).
Top sellers of RYTM stock for the quarter ending December 2025 included PERCEPTIVE ADVISORS LLC (416.56Mn), Jpmorgan Chase & Co (952.15K), PRIMECAP MANAGEMENT CO/CA/ (784.19K), FMR LLC (438.87K), VOLORIDGE INVESTMENT MANAGEMENT, LLC (307.69K).
Business Quant data shows the 10 biggest positions in Rhythm Pharmaceuticals as of December 2025 are held by RA CAPITAL MANAGEMENT, L.P. (6.67Mn), BlackRock, Inc. (6.3Mn), VANGUARD GROUP INC (6.21Mn), BAKER BROS. ADVISORS LP (5.6Mn), Goldman Sachs Group Inc (3.66Mn), PRIMECAP MANAGEMENT CO/CA/ (3.48Mn), NEA Management Company, LLC (2.91Mn), PERCEPTIVE ADVISORS LLC (2.55Mn), State Street Corp (2.2Mn), FMR LLC (1.71Mn).

271 Institutional Holders

73,720,176 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	6,666,837	985,478	17.35%	$713,618,232.00
BlackRock, Inc.	31 Dec, 2025	6,297,334	-4,881	-0.08%	$674,066,632.00
VANGUARD GROUP INC	31 Dec, 2025	6,210,916	1,214,489	24.31%	$664,816,448.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	5,604,483	0	0.00%	$599,903,860.00
Goldman Sachs Group Inc	31 Dec, 2025	3,661,732	1,768,069	93.37%	$391,951,792.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	3,478,669	-784,190	-18.40%	$372,356,730.00
NEA Management Company, LLC	31 Dec, 2025	2,909,956	0	0.00%	$311,481,690.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	2,546,391	-416,558,578	-99.39%	$272,565,693.00
State Street Corp	31 Dec, 2025	2,198,615	169,964	8.38%	$235,339,750.00
FMR LLC	31 Dec, 2025	1,706,317	-438,866	-20.46%	$182,644,125.00
Federated Hermes, Inc.	31 Dec, 2025	1,623,841	-104,044	-6.02%	$173,815,940.00
Jpmorgan Chase & Co	31 Dec, 2025	1,423,989	-952,149	-40.07%	$152,423,883.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,375,729	12,900	0.95%	$147,282,636.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,285,222	-98,553	-7.12%	$137,570,163.00
WESTFIELD CAPITAL MANAGEMENT CO LP	31 Dec, 2025	1,267,158	198,154	18.54%	$135,636,592.00
Polar Capital Holdings Plc	31 Dec, 2025	1,185,392	-59,540	-4.78%	$126,884,360.00
Janus Henderson Group Plc	31 Dec, 2025	1,126,125	-34,762	-2.99%	$120,591,241.00
Checkpoint Capital L.P.	31 Dec, 2025	992,200	228,493	29.92%	$106,205,088.00
Capital Research Global Investors	31 Dec, 2025	985,086	386,839	64.66%	$105,443,605.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	930,233	-49,449	-5.05%	$99,572,140.00

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