RYTM's three largest insider shareholders as of September 29, 2026 are David P Meeker (President And Ceo, 239.26K shares), Hunter C Smith (Chief Financial Officer, 114.02K shares), Yann Mazabraud (Evp, Head Of International, 55.66K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | David P Meeker | President And Ceo | 239,258 | 0 | 239,258 | 44.0% | 14 Sep, 2026 |
| 2 | Hunter C Smith | Chief Financial Officer | 114,024 | 0 | 114,024 | 21.0% | 01 Sep, 2026 |
| 3 | Yann Mazabraud | Evp, Head Of International | 55,655 | 0 | 55,655 | 10.2% | 14 Aug, 2026 |
| 4 | Pamela J. Cramer | Chief Human Resources Officer | 29,376 | 0 | 29,376 | 5.4% | 03 Feb, 2026 |
| 5 | Joseph Shulman | Chief Technical Officer | 15,915 | 0 | 15,915 | 2.9% | 17 Aug, 2026 |
| 6 | Edward T Mathers | Director | 0 | 14,168 | 14,168 | 2.6% | 16 Mar, 2026 |
| 7 | David W J Mcgirr | Director | 11,712 | 0 | 11,712 | 2.2% | 25 Jun, 2026 |
| 8 | Jennifer L Good | Director | 11,712 | 0 | 11,712 | 2.2% | 25 Jun, 2026 |
| 9 | Christophe Jean | Director | 11,712 | 0 | 11,712 | 2.2% | 25 Jun, 2026 |
| 10 | Stuart A Arbuckle | Director | 11,712 | 0 | 11,712 | 2.2% | 25 Jun, 2026 |
| 11 | Lynn A. Tetrault | Director | 11,712 | 0 | 11,712 | 2.2% | 25 Jun, 2026 |
| 12 | William T. Roberts | Chief Accounting Officer | 7,872 | 0 | 7,872 | 1.4% | 31 Mar, 2023 |
| 13 | Camille L Bedrosian | Director | 7,000 | 0 | 7,000 | 1.3% | 23 Jun, 2025 |
| 14 | Alastair Garfield | Chief Scientific Officer | 2,295 | 0 | 2,295 | 0.4% | 17 Aug, 2026 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 31 Aug, 2026 | Hunter C Smith | Chief Financial Officer | Acquired M | 57,187 | $25.79 | $1.47Mn | 176,798 | Direct |
| 31 Aug, 2026 | Hunter C Smith | Chief Financial Officer | Disposed S | 23,072 | $104.59 | $2.41Mn | 153,726 | Direct |
| 31 Aug, 2026 | Hunter C Smith | Chief Financial Officer | Disposed S | 11,514 | $105.37 | $1.21Mn | 142,212 | Direct |
| 31 Aug, 2026 | Hunter C Smith | Chief Financial Officer | Disposed S | 28,188 | $106.20 | $2.99Mn | 114,024 | Direct |
| 31 Aug, 2026 | Hunter C Smith | Chief Financial Officer | Disposed M | 57,187 | $0.00 | $0 | 3,813 | Direct |
| 17 Aug, 2026 | Manher Joshi | Chief Medical Officer | Acquired A | 50,000 | $0.00 | $0 | 50,000 | Direct |
| 17 Aug, 2026 | Manher Joshi | Chief Medical Officer | Acquired A | 25,000 | $0.00 | $0 | 25,000 | Direct |
| 13 Aug, 2026 | Alastair Garfield | Chief Scientific Officer | Disposed S | 2,007 | $116.11 | $233.03K | 8,051 | Direct |
| 13 Aug, 2026 | Joseph Shulman | Chief Technical Officer | Acquired M | 2,024 | $6.80 | $13.76K | 20,994 | Direct |
| 13 Aug, 2026 | Alastair Garfield | Chief Scientific Officer | Disposed S | 1,556 | $117.08 | $182.17K | 6,495 | Direct |
| 13 Aug, 2026 | Joseph Shulman | Chief Technical Officer | Disposed S | 5,079 | $119.75 | $608.21K | 15,915 | Direct |
| 13 Aug, 2026 | Joseph Shulman | Chief Technical Officer | Disposed M | 2,024 | $0.00 | $0 | 5,945 | Direct |
| 13 Aug, 2026 | Alastair Garfield | Chief Scientific Officer | Disposed S | 3,400 | $118.28 | $402.17K | 3,095 | Direct |
| 13 Aug, 2026 | Alastair Garfield | Chief Scientific Officer | Disposed S | 800 | $119.17 | $95.34K | 2,295 | Direct |
| 12 Aug, 2026 | Yann Mazabraud | Evp, Head Of International | Acquired M | 46,625 | $6.80 | $317.05K | 112,655 | Direct |
| 13 Aug, 2026 | Jennifer Kayden Lee | Evp, Head Of North America | Acquired M | 35,000 | $24.29 | $850.15K | 54,233 | Direct |
| 13 Aug, 2026 | Jennifer Kayden Lee | Evp, Head Of North America | Acquired M | 21,601 | $6.80 | $146.89K | 75,834 | Direct |
| 12 Aug, 2026 | Yann Mazabraud | Evp, Head Of International | Disposed S | 2,300 | $111.80 | $257.14K | 110,355 | Direct |
| 12 Aug, 2026 | Yann Mazabraud | Evp, Head Of International | Disposed S | 1,000 | $112.86 | $112.86K | 109,355 | Direct |
| 13 Aug, 2026 | Jennifer Kayden Lee | Evp, Head Of North America | Disposed S | 75,834 | $117.38 | $8.90Mn | 0 | Direct |