Praxis Precision Medicines's top three insider shareholders as of August 29, 2026 are Capital Management, L.P. Adage (TenPercentOwner, 2.36Mn shares), Capital Management, L.P. Adage (TenPercentOwner, 2.06Mn shares), Marcio Souza (Chief Executive Officer, 77.02K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Capital Management, L.P. Adage | TenPercentOwner | 0 | 4,421,660 | 4,421,660 | 95.8% | 17 Oct, 2025 |
| 2 | Marcio Souza | Chief Executive Officer | 56,495 | 0 | 56,495 | 1.2% | 08 Jul, 2026 |
| 3 | Timothy Edwin Kelly | Chief Financial Officer | 31,167 | 0 | 31,167 | 0.7% | 19 May, 2026 |
| 4 | Megan Sniecinski | Chief Operating Officer | 28,664 | 0 | 28,664 | 0.6% | 19 May, 2026 |
| 5 | Alex Nemiroff | General Counsel And Secretary | 26,011 | 0 | 26,011 | 0.6% | 19 May, 2026 |
| 6 | Dean J Mitchell | Director | 18,622 | 0 | 18,622 | 0.4% | 12 Jun, 2026 |
| 7 | Lauren Mastrocola | Principal Accounting Officer | 13,573 | 0 | 13,573 | 0.3% | 19 May, 2026 |
| 8 | Bernard Ravina | Chief Medical Officer | 6,632 | 0 | 6,632 | 0.1% | 15 Feb, 2022 |
| 9 | William D Young | Director | 3,269 | 0 | 3,269 | 0.1% | 12 Jun, 2026 |
| 10 | Nicole Sweeny | Chief Commercial Officer | 2,575 | 0 | 2,575 | 0.1% | 13 Feb, 2023 |
| 11 | Jill Desimone | Director | 2,337 | 0 | 2,337 | 0.1% | 26 Jun, 2026 |
| 12 | Gregory Norden | Director | 1,559 | 0 | 1,559 | 0.0% | 12 Jun, 2026 |
| 13 | Merit Ester Cudkowicz | Director | 1,371 | 0 | 1,371 | 0.0% | 12 Jun, 2026 |
| 14 | Stuart A Arbuckle | Director | 1,166 | 0 | 1,166 | 0.0% | 10 Feb, 2026 |
| 15 | Jeffrey B Kindler | Director | 1,166 | 0 | 1,166 | 0.0% | 10 Feb, 2026 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 08 Jul, 2026 | Marcio Souza | Chief Executive Officer | Disposed G | 20,521 | $0.00 | $0 | 56,495 | Direct |
| 08 Jul, 2026 | Marcio Souza | Chief Executive Officer | Disposed G | 2,600 | $0.00 | $0 | 0 | Indirect |
| 24 Jun, 2026 | Jill Desimone | Director | Acquired M | 8,566 | $44.25 | $379.05K | 10,903 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Acquired M | 3,034 | $147.30 | $446.91K | 13,937 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 10 | $301.44 | $3.01K | 13,927 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 120 | $303.13 | $36.38K | 13,807 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 320 | $305.31 | $97.70K | 13,487 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 683 | $306.77 | $209.52K | 12,804 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 1,240 | $308.24 | $382.22K | 11,564 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 999 | $309.38 | $309.07K | 10,565 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 1,750 | $310.89 | $544.06K | 8,815 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 2,854 | $311.91 | $890.20K | 5,961 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 1,004 | $312.83 | $314.08K | 4,957 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 504 | $313.66 | $158.09K | 4,453 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 1,279 | $314.90 | $402.76K | 3,174 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed S | 837 | $315.71 | $264.25K | 2,337 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed M | 8,566 | $0.00 | $0 | 0 | Direct |
| 24 Jun, 2026 | Jill Desimone | Director | Disposed M | 3,034 | $0.00 | $0 | 0 | Direct |
| 10 Jun, 2026 | Merit Ester Cudkowicz | Director | Acquired A | 1,371 | $0.00 | $0 | 1,371 | Direct |
| 10 Jun, 2026 | Jill Desimone | Director | Acquired A | 1,371 | $0.00 | $0 | 2,337 | Direct |