Praxis Precision Medicines, Inc. (PRAX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

21,977,268Shares Outstanding

29,407,277Shares held by institutions

$9,396,507,220Value of institutional holdings

133.81%Institutional ownership %

23.80%Shares Changed QoQ

246No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Praxis Precision Medicines, Inc. (NASDAQ:PRAX) appears in 246 institutional 13F filings for the quarter ending December 2025.

Their combined ownership stood at 130.5% of outstanding shares in December 2025, up from 114.6% in September 2025.
They increased total shares held in Praxis Precision Medicines by 21.35% from the prior quarter, while the number of investors in PRAX increased 53.75% year over year.
Activity in PRAX broke down as 197 buyers, 44 sellers, and 5 unchanged among 246 total holders.
In total, institutional investors held 28.69Mn shares in Praxis Precision Medicines as of December 2025, up by 5.05Mn shares quarter on quarter, and up 5.7Mn shares year over year.
As of December 31, 2025, the biggest holder of Praxis Precision Medicines is Janus Henderson Group Plc at 3.24Mn shares, representing 14.74% of shares outstanding.
The biggest buyers of Praxis Precision Medicines for the quarter ending December 2025 included FMR LLC (1.32Mn), Orbis Allan Gray Ltd (1.26Mn), Goldman Sachs Group Inc (839.35K), Janus Henderson Group Plc (476.23K), BAKER BROS. ADVISORS LP (437.0K).
Leading sellers of Praxis Precision Medicines shares for the quarter ending December 2025 were ADAGE CAPITAL PARTNERS GP, L.L.C. (1.41Mn), Point72 Asset Management, L.P. (1.0Mn), Soleus Capital Management, L.P. (496.2K), Bank Of America Corp /De/ (442.96K), CIBC Asset Management Inc (387.86K).
According to Business Quant data, leading holders of PRAX for December 2025 are Janus Henderson Group Plc (3.24Mn), BlackRock, Inc. (2.08Mn), PERCEPTIVE ADVISORS LLC (2.0Mn), VANGUARD GROUP INC (1.46Mn), Goldman Sachs Group Inc (1.43Mn), FMR LLC (1.36Mn), Orbis Allan Gray Ltd (1.26Mn), BAKER BROS. ADVISORS LP (1.13Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (965.31K), Cormorant Asset Management, LP (950.0K).

246 Institutional Holders

29,407,277 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Janus Henderson Group Plc	31 Dec, 2025	3,240,086	476,227	17.23%	$954,833,974.00
BlackRock, Inc.	31 Dec, 2025	2,078,500	277,420	15.40%	$612,617,092.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,995,986	431,432	27.58%	$588,296,914.00
VANGUARD GROUP INC	31 Dec, 2025	1,460,933	193,647	15.28%	$430,595,392.00
Goldman Sachs Group Inc	31 Dec, 2025	1,432,368	839,347	141.54%	$422,176,144.00
FMR LLC	31 Dec, 2025	1,358,675	1,315,464	3,044.28%	$400,455,884.00
Orbis Allan Gray Ltd	31 Dec, 2025	1,255,162	1,255,162	0.00%	$369,946,448.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	1,126,488	437,000	63.38%	$332,021,073.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	965,313	-1,408,772	-59.34%	$284,516,354.00
Cormorant Asset Management, LP	31 Dec, 2025	950,000	-50,000	-5.00%	$280,003,000.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	933,061	432,510	86.41%	$275,010,399.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	903,351	62,500	7.43%	$266,253,674.00
Morgan Stanley	31 Dec, 2025	889,889	246,394	38.29%	$262,286,289.00
State Street Corp	31 Dec, 2025	882,215	-24,893	-2.74%	$260,024,049.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	562,379	105,347	23.05%	$165,783,193.00
Barclays Plc	31 Dec, 2025	530,751	340,347	178.75%	$156,433,549.00
Bank Of America Corp /De/	31 Dec, 2025	522,763	-442,959	-45.87%	$154,079,168.00
Point72 Asset Management, L.P.	31 Dec, 2025	492,346	-1,003,640	-67.09%	$145,114,060.00
Assenagon Asset Management S.A.	31 Dec, 2025	408,787	-992	-0.24%	$120,485,880.00
Logos Global Management LP	31 Dec, 2025	375,000	250,000	200.00%	$110,527,500.00

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