Praxis Precision Medicines, Inc. (PRAX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

21,067,593Shares Outstanding

89,284Shares held by institutions

$29,288,723Value of institutional holdings

136.77%Institutional ownership %

22.46%Shares Changed QoQ

241No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Praxis Precision Medicines, Inc. (NASDAQ:PRAX) currently has 241 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The collective stake of institutional investors in Praxis Precision Medicines moved to 136.8% in December 2025, a shift up from the 119.0% reported for September 2025.
The company experienced a 22.46% quarterly change in institutional shares held, alongside an increase of 49.69% in total owners annually.
Among the 241 institutional holders of Praxis Precision Medicines, 193 added to their stakes while 43 trimmed their positions and 5 held steady.
This class of investors increased its holdings in Praxis Precision Medicines to 28.81Mn shares for the 13F-cycle ending December 2025, up by 5.28Mn shares quarter on quarter, and up 6.44Mn shares year over year.
JANUS HENDERSON GROUP PLC's holding of 3.24Mn shares as of December 31, 2025 makes it the primary institutional investor in Praxis Precision Medicines, owning 15.38% of the stock.
Among the most significant buyers of Praxis Precision Medicines during December 2025 were FMR LLC (1.32Mn), Orbis Allan Gray Ltd (1.26Mn), JANUS HENDERSON GROUP PLC (476.23K), BARCLAYS PLC (454.11K), BAKER BROS. ADVISORS LP (437.00K).
Leading sellers of Praxis Precision Medicines stock in December 2025 included ADAGE CAPITAL PARTNERS GP, L.L.C. (1.41Mn), Point72 Asset Management, L.P. (1.00Mn), Soleus Capital Management, L.P. (496.20K), CIBC Asset Management Inc (387.86K), Woodline Partners LP (312.26K).
The top 10 institutional holders of Praxis Precision Medicines for the quarter ending December 2025 included JANUS HENDERSON GROUP PLC (3.24Mn), BlackRock, Inc. (2.08Mn), PERCEPTIVE ADVISORS LLC (2.00Mn), VANGUARD GROUP INC (1.46Mn), FMR LLC (1.36Mn), Orbis Allan Gray Ltd (1.26Mn), BAKER BROS. ADVISORS LP (1.13Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (965.31K), Cormorant Asset Management, LP (950.00K), DRIEHAUS CAPITAL MANAGEMENT LLC (933.06K).

241 Institutional Holders

89,284 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
JANUS HENDERSON GROUP PLC	31 Dec, 2025	3,240,086	476,227	17.23%	$954,833,974.00
BlackRock, Inc.	31 Dec, 2025	2,078,500	277,420	15.40%	$612,617,092.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,995,986	431,432	27.58%	$588,296,914.00
VANGUARD GROUP INC	31 Dec, 2025	1,460,933	193,647	15.28%	$430,595,392.00
FMR LLC	31 Dec, 2025	1,358,675	1,315,464	3,044.28%	$400,455,884.00
Orbis Allan Gray Ltd	31 Dec, 2025	1,255,162	1,255,162	0.00%	$369,946,448.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	1,126,488	437,000	63.38%	$332,021,073.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	965,313	-1,408,772	-59.34%	$284,516,354.00
Cormorant Asset Management, LP	31 Dec, 2025	950,000	-50,000	-5.00%	$280,003,000.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	933,061	432,510	86.41%	$275,010,399.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	903,351	62,500	7.43%	$266,253,674.00
MORGAN STANLEY	31 Dec, 2025	889,889	246,394	38.29%	$262,286,289.00
STATE STREET CORP	31 Dec, 2025	882,215	-24,893	-2.74%	$260,024,049.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	716,184	123,163	20.77%	$211,088,072.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	562,379	105,347	23.05%	$165,783,193.00
BARCLAYS PLC	31 Dec, 2025	530,751	454,114	592.55%	$156,433,549.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	522,763	39,902	8.26%	$154,079,168.00
Point72 Asset Management, L.P.	31 Dec, 2025	492,346	-1,003,640	-67.09%	$145,114,060.00
Assenagon Asset Management S.A.	31 Dec, 2025	408,787	-992	-0.24%	$120,485,880.00
Logos Global Management LP	31 Dec, 2025	375,000	250,000	200.00%	$110,527,500.00

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