Praxis Precision Medicines, Inc. (PRAX) Institutional Ownership

Ownership Summary

Praxis Precision Medicines, Inc. (NASDAQ:PRAX) is held by 246 institutional investors per 13F filings through December 2025.

• Their combined ownership stood at 130.5% of outstanding shares in December 2025, up from 114.6% in September 2025.
• They increased total shares held in PRAX by 21.35% quarter over quarter, and investors in Praxis Precision Medicines increased 53.75% from a year ago.
• During the quarter, 197 of these 246 funds increased positions in PRAX, 44 reduced exposure, and 5 held steady.
• In total, institutional investors held 28.69Mn shares in Praxis Precision Medicines as of December 2025, up by 5.05Mn shares quarter on quarter, and up 5.7Mn shares year over year.
• Janus Henderson Group Plc holds the largest position in PRAX at 3.54Mn shares as of December 31, 2025, or 16.12% of shares outstanding.
• The most significant purchases of PRAX for the quarter ending December 2025 came from VANGUARD CAPITAL MANAGEMENT LLC (1.22Mn), Orbis Allan Gray Ltd (1.22Mn), FMR LLC (802.27K), VANGUARD PORTFOLIO MANAGEMENT LLC (756.75K), PRICE T ROWE ASSOCIATES INC /MD/ (630.85K).
• The largest sellers of Praxis Precision Medicines for the quarter ending December 2025 were Goldman Sachs Group Inc (721.63K), Barclays Plc (523.77K), ADAGE CAPITAL PARTNERS GP, L.L.C. (149.57K), T. Rowe Price Investment Management, Inc. (119.17K), Logos Global Management LP (90.0K).
• Praxis Precision Medicines's 10 largest shareholders as of December 2025 include Janus Henderson Group Plc (3.54Mn), Orbis Allan Gray Ltd (2.47Mn), BlackRock, Inc. (2.32Mn), FMR LLC (2.16Mn), PERCEPTIVE ADVISORS LLC (2.04Mn), BAKER BROS. ADVISORS LP (1.75Mn), VANGUARD CAPITAL MANAGEMENT LLC (1.22Mn), DEERFIELD MANAGEMENT COMPANY, L.P. (963.35K), DRIEHAUS CAPITAL MANAGEMENT LLC (949.22K), Cormorant Asset Management, LP (885.5K) per Business Quant data.