Praxis Precision Medicines, Inc. (PRAX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

738,270Shares held by institutions

$204,087,359Value of institutional holdings

107.83%Institutional ownership %

7.50%Shares Changed QoQ

141No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Praxis Precision Medicines, Inc. (NASDAQ:PRAX) has 246 institutional investors that have filed 13F reports for the period ending December 2025.

These investors collectively held 130.5% of Praxis Precision Medicines's outstanding shares in December 2025, up from 114.6% in September 2025.
They increased total shares held in Praxis Precision Medicines by 21.35% from last quarter, and the number of investors in PRAX increased 53.75% annually.
During the quarter, 197 of these 246 funds increased positions in PRAX, 44 reduced exposure, and 5 held steady.
In total, institutional investors held 28.69Mn shares in Praxis Precision Medicines as of December 2025, up by 5.05Mn shares quarter on quarter, and up 5.7Mn shares year over year.
Janus Henderson Group Plc leads ownership in PRAX with 3.24Mn shares as of December 31, 2025, equal to 14.74% of outstanding shares.
The biggest buyers of Praxis Precision Medicines for the quarter ending December 2025 included FMR LLC (1.32Mn), Orbis Allan Gray Ltd (1.26Mn), Janus Henderson Group Plc (476.23K), Barclays Plc (454.11K), BAKER BROS. ADVISORS LP (437.0K).
Leading sellers of Praxis Precision Medicines shares for the quarter ending December 2025 were ADAGE CAPITAL PARTNERS GP, L.L.C. (1.41Mn), Point72 Asset Management, L.P. (1.0Mn), Soleus Capital Management, L.P. (496.2K), Bank Of America Corp /De/ (442.96K), CIBC Asset Management Inc (387.86K).
Per Business Quant data, the top 10 holders of Praxis Precision Medicines for the quarter ending December 2025 are Janus Henderson Group Plc (3.24Mn), BlackRock, Inc. (2.08Mn), PERCEPTIVE ADVISORS LLC (2.0Mn), VANGUARD GROUP INC (1.46Mn), FMR LLC (1.36Mn), Orbis Allan Gray Ltd (1.26Mn), BAKER BROS. ADVISORS LP (1.13Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (965.31K), Cormorant Asset Management, LP (950.0K), DRIEHAUS CAPITAL MANAGEMENT LLC (933.06K).

246 Institutional Holders

738,270 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	277,420	15.40%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	476,227	17.23%	$0.00
Orbis Allan Gray Ltd	31 Dec, 2025	1,255,162	0.00%	$0.00
Barclays Plc	31 Dec, 2025	416,984	366.52%	$0.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	431,432	27.58%	$0.00
Point72 Asset Management, L.P.	31 Dec, 2025	-1,003,640	-67.09%	$0.00
HSBC HOLDINGS PLC	31 Dec, 2025	-9,522	-85.23%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	193,647	15.28%	$0.00
Logos Global Management LP	31 Dec, 2025	250,000	200.00%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	126	6,300.00%	$0.00
FMR LLC	31 Dec, 2025	1,315,464	3,044.28%	$0.00
Soleus Capital Management, L.P.	31 Dec, 2025	-496,200	-57.75%	$0.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	437,000	63.38%	$0.00
Vivo Capital, LLC	31 Dec, 2025	130,000	65.36%	$0.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	-1,408,772	-59.34%	$0.00
T. Rowe Price Investment Management, Inc.	31 Dec, 2025	294,410	0.00%	$0.00
Cormorant Asset Management, LP	31 Dec, 2025	-50,000	-5.00%	$0.00
Pictet Asset Management Holding SA	31 Dec, 2025	240,588	0.00%	$0.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	432,510	86.41%	$0.00
Affinity Asset Advisors, LLC	31 Dec, 2025	185,000	0.00%	$0.00

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