Opko Health, Inc. (OPK) Institutional Ownership

Ownership Summary

Opko Health, Inc. (NASDAQ:OPK) has 213 institutional investors that have filed 13F reports for the period ending December 2025.

• Their combined ownership stood at 25.5% of outstanding shares in December 2025, up from 25.5% in September 2025.
• They increased total shares held in Opko Health by 1.88% from the prior quarter, while the number of investors in OPK decreased 6.99% year over year.
• During the quarter, 72 of these 213 funds increased positions in OPK, 76 reduced exposure, and 65 held steady.
• Altogether, these fund groups held 199.17Mn shares in OPK by December 2025, up by 3.68Mn shares quarter on quarter, and down 4.22Mn shares year over year.
• As of December 31, 2025, the biggest holder of Opko Health is Rubric Capital Management LP at 47.79Mn shares, representing 6.13% of shares outstanding.
• Leading buyers of Opko Health shares for the quarter ending December 2025 were VANGUARD PORTFOLIO MANAGEMENT LLC (14.77Mn), VANGUARD CAPITAL MANAGEMENT LLC (14.5Mn), VANGUARD FIDUCIARY TRUST CO (2.74Mn), OP Asset Management Ltd (2.2Mn), BlackRock, Inc. (1.38Mn).
• The largest sellers of Opko Health for the quarter ending December 2025 were Goldman Sachs Group Inc (4.3Mn), AQR CAPITAL MANAGEMENT LLC (1.26Mn), CITADEL ADVISORS LLC (777.89K), JANE STREET GROUP, LLC (660.96K), HRT FINANCIAL LP (584.72K).
• Business Quant data shows the 10 biggest positions in Opko Health as of December 2025 are held by Rubric Capital Management LP (47.79Mn), BlackRock, Inc. (36.23Mn), VANGUARD PORTFOLIO MANAGEMENT LLC (14.77Mn), VANGUARD CAPITAL MANAGEMENT LLC (14.5Mn), GEODE CAPITAL MANAGEMENT, LLC (11.3Mn), State Street Corp (9.5Mn), Goldman Sachs Group Inc (7.68Mn), UBS Group AG (6.07Mn), Whitefort Capital Management, LP (4.25Mn), Northern Trust Corp (3.62Mn).