Opko Health, Inc. (OPK) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

442,445,455Shares Outstanding

5,126,622Shares held by institutions

$6,254,479Value of institutional holdings

16.86%Institutional ownership %

4.75%Shares Changed QoQ

177No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 208 institutions have reported a stake in Opko Health, Inc. (NASDAQ:OPK) as of December 2025, according to recent 13F filings with the SEC.

Institutional ownership in Opko Health edged up to 27.5% in December 2025, compared to 27.4% in September 2025.
The company experienced a 2.52% quarterly change in institutional shares held, alongside a decrease of 9.57% in total owners annually.
During the quarter, 68 institutions bought more Opko Health shares, 72 sold shares, and 68 of the 208 total investors held their position steady.
Collectively, institutional investors increased their stake in Opko Health to 198.27Mn shares as of December 2025, a change that is up by 4.88Mn shares quarter on quarter and up 69.29K shares year over year.
As of December 31, 2025, Rubric Capital Management LP held Opko Health's largest shareholding position with over 47.79Mn shares, representing 6.63% of total outstanding shares.
Among the most significant buyers of Opko Health during December 2025 were GOLDMAN SACHS GROUP INC (3.60Mn), CITADEL ADVISORS LLC (2.58Mn), BlackRock, Inc. (1.68Mn), JANE STREET GROUP, LLC (1.51Mn), HRT FINANCIAL LP (675.48K).
Leading sellers of Opko Health stock in December 2025 included VANGUARD GROUP INC (5.08Mn), AQR CAPITAL MANAGEMENT LLC (846.46K), BANK OF AMERICA CORP /DE/ (695.62K), Whitefort Capital Management, LP (646.66K), TWO SIGMA INVESTMENTS, LP (520.90K).
The top 10 institutional holders of Opko Health for the quarter ending December 2025 included Rubric Capital Management LP (47.79Mn), BlackRock, Inc. (34.85Mn), VANGUARD GROUP INC (32.46Mn), GEODE CAPITAL MANAGEMENT, LLC (11.06Mn), STATE STREET CORP (8.95Mn), GOLDMAN SACHS GROUP INC (5.99Mn), UBS Group AG (5.35Mn), Whitefort Capital Management, LP (4.25Mn), CHARLES SCHWAB INVESTMENT MANAGEMENT INC (3.69Mn), NORTHERN TRUST CORP (3.44Mn).

208 Institutional Holders

5,126,622 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Rubric Capital Management LP	31 Dec, 2025	47,791,243	0	0.00%	$60,216,966.00
BlackRock, Inc.	31 Dec, 2025	34,852,030	1,679,646	5.06%	$43,913,559.00
VANGUARD GROUP INC	31 Dec, 2025	32,457,788	-5,078,109	-13.53%	$40,896,813.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	11,061,318	67,973	0.62%	$13,939,903.00
STATE STREET CORP	31 Dec, 2025	8,951,762	-46,178	-0.51%	$11,279,220.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	5,986,913	3,600,378	150.86%	$7,543,511.00
UBS Group AG	31 Dec, 2025	5,352,784	577,248	12.09%	$6,744,509.00
Whitefort Capital Management, LP	31 Dec, 2025	4,253,340	-646,660	-13.20%	$5,359,208.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	3,692,650	-76,284	-2.02%	$4,652,739.00
NORTHERN TRUST CORP	31 Dec, 2025	3,438,312	-219,534	-6.00%	$4,332,273.00
CITADEL ADVISORS LLC	31 Dec, 2025	2,857,433	2,577,558	920.97%	$3,600,366.00
AWM Investment Company, Inc.	31 Dec, 2025	2,100,000	-100,000	-4.55%	$2,646,000.00
AQR CAPITAL MANAGEMENT LLC	31 Dec, 2025	2,026,957	-846,459	-29.46%	$2,553,965.00
JANE STREET GROUP, LLC	31 Dec, 2025	1,822,936	1,513,898	489.87%	$2,296,899.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,611,318	-56,050	-3.36%	$2,031,403.00
WASHINGTON GROWTH STRATEGIES LLC	31 Dec, 2025	1,356,124	0	0.00%	$1,708,717.00
PFG Investments, LLC	31 Dec, 2025	1,320,391	-16,984	-1.27%	$1,663,693.00
Bank of New York Mellon Corp	31 Dec, 2025	1,310,094	33,226	2.60%	$1,650,718.00
Y.D. More Investments Ltd	31 Dec, 2025	1,306,452	-192,666	-12.85%	$1,670,948.00
VOYA INVESTMENT MANAGEMENT LLC	31 Dec, 2025	1,102,174	-115,828	-9.51%	$1,388,739.00

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