Opko Health, Inc. (OPK) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

779,919,259Shares Outstanding

205,276,442Shares held by institutions

$250,437,259Value of institutional holdings

26.32%Institutional ownership %

4.37%Shares Changed QoQ

214No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Opko Health, Inc. (NASDAQ:OPK) showed up in the 13F filings of 213 institutional investors as of December 2025.

Collectively, these holders controlled 25.5% of Opko Health's outstanding shares in December 2025, up from 25.5% in September 2025.
They increased total shares held in Opko Health by 1.88% from last quarter, and the number of investors in OPK decreased 6.99% annually.
Of these 213 funds, 72 grew their exposure to Opko Health, 76 cut back, and 65 maintained positions.
In total, institutional investors held 199.17Mn shares in Opko Health as of December 2025, up by 3.68Mn shares quarter on quarter, and down 4.22Mn shares year over year.
Rubric Capital Management LP leads ownership in OPK with 47.79Mn shares as of December 31, 2025, equal to 6.13% of outstanding shares.
The biggest buyers of Opko Health for the quarter ending December 2025 included Goldman Sachs Group Inc (9.59Mn), CITADEL ADVISORS LLC (2.58Mn), BlackRock, Inc. (1.68Mn), JANE STREET GROUP, LLC (1.51Mn), Clearstead Advisors, LLC (882.37K).
The largest sellers of Opko Health for the quarter ending December 2025 were VANGUARD GROUP INC (5.08Mn), Bank Of America Corp /De/ (2.01Mn), Barclays Plc (1.06Mn), AQR CAPITAL MANAGEMENT LLC (846.46K), Whitefort Capital Management, LP (646.66K).
Per Business Quant data, the top 10 holders of Opko Health for the quarter ending December 2025 are Rubric Capital Management LP (47.79Mn), BlackRock, Inc. (34.85Mn), VANGUARD GROUP INC (32.46Mn), Goldman Sachs Group Inc (11.97Mn), GEODE CAPITAL MANAGEMENT, LLC (11.06Mn), State Street Corp (8.95Mn), UBS Group AG (5.35Mn), Whitefort Capital Management, LP (4.25Mn), CHARLES SCHWAB INVESTMENT MANAGEMENT INC (3.69Mn), Northern Trust Corp (3.44Mn).

214 Institutional Holders

205,276,442 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Rubric Capital Management LP	31 Dec, 2025	47,791,243	0	0.00%	$60,216,966.00
BlackRock, Inc.	31 Dec, 2025	34,852,030	1,679,646	5.06%	$43,913,559.00
VANGUARD GROUP INC	31 Dec, 2025	32,457,788	-5,078,109	-13.53%	$40,896,813.00
Goldman Sachs Group Inc	31 Dec, 2025	11,973,826	9,587,291	401.72%	$15,087,022.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	11,061,318	67,973	0.62%	$13,939,903.00
State Street Corp	31 Dec, 2025	8,951,762	-46,178	-0.51%	$11,279,220.00
UBS Group AG	31 Dec, 2025	5,352,784	577,248	12.09%	$6,744,509.00
Whitefort Capital Management, LP	31 Dec, 2025	4,253,340	-646,660	-13.20%	$5,359,208.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	3,692,650	-76,284	-2.02%	$4,652,739.00
Northern Trust Corp	31 Dec, 2025	3,438,312	-219,534	-6.00%	$4,332,273.00
CITADEL ADVISORS LLC	31 Dec, 2025	2,857,433	2,577,558	920.97%	$3,600,366.00
AWM Investment Company, Inc.	31 Dec, 2025	2,100,000	-100,000	-4.55%	$2,646,000.00
AQR CAPITAL MANAGEMENT LLC	31 Dec, 2025	2,026,957	-846,459	-29.46%	$2,553,965.00
JANE STREET GROUP, LLC	31 Dec, 2025	1,775,336	1,512,498	575.45%	$2,236,923.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,611,318	-56,050	-3.36%	$2,031,403.00
WASHINGTON GROWTH STRATEGIES LLC	31 Dec, 2025	1,356,124	0	0.00%	$1,708,717.00
PFG Investments, LLC	31 Dec, 2025	1,320,391	-16,984	-1.27%	$1,663,693.00
Bank of New York Mellon Corp	31 Dec, 2025	1,310,094	33,226	2.60%	$1,650,718.00
Y.D. More Investments Ltd	31 Dec, 2025	1,306,452	-192,666	-12.85%	$1,670,948.00
VOYA INVESTMENT MANAGEMENT LLC	31 Dec, 2025	1,102,174	-115,828	-9.51%	$1,388,739.00

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