As of September 17, 2026, Opko Health's top three insider holders are Phillip Md Et Al Frost (Ceo Chairman, 216.71Mn shares), Phillip Md Et Al Frost (Ceo Chairman, 203.97Mn shares), Gary J. Nabel (Chief Innovation Officer, 39.80Mn shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Phillip Md Et Al Frost | Ceo Chairman | 0 | 216,706,448 | 216,706,448 | 85.1% | 21 Nov, 2025 |
| 2 | Jane Ph D Hsiao | Vice Chairman Cto | 28,499,880 | 0 | 28,499,880 | 11.2% | 26 Jul, 2024 |
| 3 | Steven D Rubin | Executive Vp Administration | 6,571,966 | 0 | 6,571,966 | 2.6% | 28 Jul, 2026 |
| 4 | Gary J. Nabel | Chief Innovation Officer | 700,579 | 0 | 700,579 | 0.3% | 26 Jul, 2024 |
| 5 | Elias A. Zerhouni | Vice Chairman And President | 589,600 | 0 | 589,600 | 0.2% | 26 Jul, 2024 |
| 6 | Adam Logal | Sr. Vice President, Cfo | 563,396 | 0 | 563,396 | 0.2% | 28 Jul, 2026 |
| 7 | John A Paganelli | Director | 394,340 | 0 | 394,340 | 0.2% | 20 Mar, 2026 |
| 8 | Richard C Jr Pfenniger | Director | 325,000 | 0 | 325,000 | 0.1% | 05 Jan, 2024 |
| 9 | Alexis Borisy | Director | 312,612 | 0 | 312,612 | 0.1% | 13 May, 2022 |
| 10 | Richard M Krasno | Director | 0 | 103,333 | 103,333 | 0.0% | 29 Jan, 2024 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 24 Jul, 2026 | Steven D Rubin | Executive Vp Administration | Disposed F | 53,266 | $1.22 | $64.98K | 6,571,966 | Direct |
| 24 Jul, 2026 | Adam Logal | Sr. Vice President, Cfo | Disposed F | 53,266 | $1.22 | $64.98K | 563,396 | Direct |
| 18 Jun, 2026 | Richard C Jr Pfenniger | Director | Acquired A | 60,000 | $0.00 | $0 | 60,000 | Direct |
| 18 Jun, 2026 | Subbarao V Uppaluri | Director | Acquired A | 80,000 | $0.00 | $0 | 80,000 | Direct |
| 18 Jun, 2026 | John A Paganelli | Director | Acquired A | 30,000 | $0.00 | $0 | 30,000 | Direct |
| 18 Jun, 2026 | Alice Lin-Tsing Yu | Director | Acquired A | 30,000 | $0.00 | $0 | 30,000 | Direct |
| 18 Jun, 2026 | Roger Md Medel | Director | Acquired A | 30,000 | $0.00 | $0 | 30,000 | Direct |
| 18 Jun, 2026 | Prem A Lachman | Director | Acquired A | 30,000 | $0.00 | $0 | 30,000 | Direct |
| 20 Mar, 2026 | John A Paganelli | Director | Acquired P | 10,000 | $1.14 | $11.35K | 394,340 | Direct |
| 18 Mar, 2026 | Subbarao V Uppaluri | Director | Acquired A | 50,000 | $0.00 | $0 | 50,000 | Direct |
| 21 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 102,371 | $1.30 | $133.08K | 216,228,819 | Indirect |
| 21 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 3,894 | $1.32 | $5.14K | 216,232,713 | Indirect |
| 21 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 89,375 | $1.33 | $118.42K | 216,322,088 | Indirect |
| 21 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 191,490 | $1.33 | $254.68K | 216,513,578 | Indirect |
| 21 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 192,870 | $1.34 | $257.48K | 216,706,448 | Indirect |
| 20 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 119,129 | $1.32 | $157.25K | 215,665,577 | Indirect |
| 20 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 47,105 | $1.33 | $62.41K | 215,712,682 | Indirect |
| 20 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 211,948 | $1.33 | $281.89K | 215,924,630 | Indirect |
| 20 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 161,818 | $1.34 | $216.03K | 216,086,448 | Indirect |
| 20 Nov, 2025 | Phillip Md Et Al Frost | Ceo Chairman | Acquired P | 24,579 | $1.34 | $32.94K | 216,111,027 | Indirect |