Madrigal Pharmaceuticals, Inc. (MDGL) Institutional Ownership

Ownership Summary

Madrigal Pharmaceuticals, Inc. (NASDAQ:MDGL) is held by 380 institutional investors per 13F filings through December 2025.

• Collectively, these holders controlled 103.1% of Madrigal Pharmaceuticals's outstanding shares in December 2025, down from 105.5% in September 2025.
• They increased total shares held in Madrigal Pharmaceuticals by 1.23% from last quarter, and the number of investors in MDGL increased 35.71% annually.
• During the quarter, 216 of these 380 funds increased positions in MDGL, 113 reduced exposure, and 51 held steady.
• Institutional investors collectively held 23.18Mn shares in Madrigal Pharmaceuticals as of December 2025, up by 282.4K shares quarter on quarter, and down 346.02K shares year over year.
• Janus Henderson Group Plc holds the largest position in MDGL at 4.04Mn shares as of December 31, 2025, or 17.96% of shares outstanding.
• Leading buyers of Madrigal Pharmaceuticals shares for the quarter ending December 2025 were Janus Henderson Group Plc (2.45Mn), VANGUARD PORTFOLIO MANAGEMENT LLC (841.14K), VANGUARD CAPITAL MANAGEMENT LLC (827.14K), CITADEL ADVISORS LLC (417.71K), PRICE T ROWE ASSOCIATES INC /MD/ (328.11K).
• The biggest sellers of Madrigal Pharmaceuticals for the quarter ending December 2025 included Avoro Capital Advisors LLC (1.8Mn), Goldman Sachs Group Inc (334.31K), PAULSON & CO. INC. (315.33K), Bank Of America Corp /De/ (226.5K), ALKEON CAPITAL MANAGEMENT LLC (160.0K).
• Business Quant data shows the 10 biggest positions in Madrigal Pharmaceuticals as of December 2025 are held by Janus Henderson Group Plc (4.04Mn), BAKER BROS. ADVISORS LP (2.14Mn), RTW INVESTMENTS, LP (1.99Mn), Avoro Capital Advisors LLC (1.82Mn), BlackRock, Inc. (1.56Mn), PAULSON & CO. INC. (1.39Mn), VANGUARD PORTFOLIO MANAGEMENT LLC (841.14K), VANGUARD CAPITAL MANAGEMENT LLC (827.14K), WELLINGTON MANAGEMENT GROUP LLP (694.96K), State Street Corp (609.52K).