Madrigal Pharmaceuticals, Inc. (MDGL) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

22,430,178Shares Outstanding

4,191,191Shares held by institutions

$2,042,451,198Value of institutional holdings

102.51%Institutional ownership %

1.87%Shares Changed QoQ

370No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Madrigal Pharmaceuticals, Inc. (NASDAQ:MDGL) includes 370 filers as of the latest reporting cycle ending December 2025.

Institutional ownership in Madrigal Pharmaceuticals edged down to 102.5% in December 2025, compared to 106.0% in September 2025.
Institutional share ownership changed by 1.87% QoQ, while the number of institutional owners saw an increase of 30.74% YoY.
A review of institutional activity for Madrigal Pharmaceuticals shows 211 of 370 filers increasing their positions, while 110 reduced their stake, and 49 remained unchanged.
The aggregate institutional position in Madrigal Pharmaceuticals now stands at 22.99Mn shares as of December 2025, after investors increased their holdings (up by 421.65K shares quarter on quarter which is down 929.55K shares year over year).
As of December 31, 2025, BAKER BROS. ADVISORS LP held Madrigal Pharmaceuticals's largest shareholding position with over 2.14Mn shares, representing 9.55% of total outstanding shares.
Among the most significant buyers of Madrigal Pharmaceuticals during December 2025 were NORGES BANK (196.39K), BANK OF AMERICA CORP /DE/ (171.73K), DEUTSCHE BANK AG\ (154.77K), ARMISTICE CAPITAL, LLC (145.72K), LORD, ABBETT & CO. LLC (142.65K).
Leading sellers of Madrigal Pharmaceuticals stock in December 2025 included JANUS HENDERSON GROUP PLC (257.85K), PAULSON & CO. INC. (200.00K), UBS Group AG (114.70K), MORGAN STANLEY (99.19K), Affinity Asset Advisors, LLC (83.87K).
The top 10 institutional holders of Madrigal Pharmaceuticals for the quarter ending December 2025 included BAKER BROS. ADVISORS LP (2.14Mn), RTW INVESTMENTS, LP (1.99Mn), VANGUARD GROUP INC (1.81Mn), Avoro Capital Advisors LLC (1.81Mn), PAULSON & CO. INC. (1.71Mn), BlackRock, Inc. (1.64Mn), JANUS HENDERSON GROUP PLC (1.58Mn), STATE STREET CORP (583.00K), WELLINGTON MANAGEMENT GROUP LLP (461.40K), GEODE CAPITAL MANAGEMENT, LLC (451.74K).

370 Institutional Holders

4,191,191 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BAKER BROS. ADVISORS LP	31 Dec, 2025	2,141,701	0	0.00%	$1,247,198,160.00
RTW INVESTMENTS, LP	31 Dec, 2025	1,993,687	0	0.00%	$1,161,003,688.00
VANGUARD GROUP INC	31 Dec, 2025	1,808,894	-3,160	-0.17%	$1,053,391,331.00
Avoro Capital Advisors LLC	31 Dec, 2025	1,807,500	-25,500	-1.39%	$1,052,579,550.00
PAULSON & CO. INC.	31 Dec, 2025	1,707,522	-200,001	-10.48%	$994,358,361.00
BlackRock, Inc.	31 Dec, 2025	1,644,750	85,038	5.45%	$957,803,431.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	1,584,843	-257,847	-13.99%	$918,203,904.00
STATE STREET CORP	31 Dec, 2025	583,003	-75,094	-11.41%	$339,505,967.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	461,402	56,947	14.08%	$268,692,841.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	451,743	5,510	1.23%	$263,113,834.00
FMR LLC	31 Dec, 2025	439,398	38,262	9.54%	$255,879,233.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	416,025	171,733	70.30%	$242,267,998.00
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	31 Dec, 2025	354,220	-57,582	-13.98%	$206,276,475.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	305,831	-80,269	-20.79%	$178,097,625.00
JANE STREET GROUP, LLC	31 Dec, 2025	276,414	-20,020	-6.75%	$160,966,928.00
Polar Capital Holdings Plc	31 Dec, 2025	270,151	4,997	1.88%	$157,319,733.00
ARMISTICE CAPITAL, LLC	31 Dec, 2025	265,705	145,723	121.45%	$154,730,650.00
Hood River Capital Management LLC	31 Dec, 2025	247,560	4,752	1.96%	$144,164,090.00
LORD, ABBETT & CO. LLC	31 Dec, 2025	244,796	142,653	139.66%	$142,555.00
ALKEON CAPITAL MANAGEMENT LLC	31 Dec, 2025	240,000	120,000	100.00%	$139,761,600.00

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