Arrowhead Pharmaceuticals, Inc. (ARWR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

132,199,346Shares Outstanding

1,198,599Shares held by institutions

$76,338,770Value of institutional holdings

86.96%Institutional ownership %

5.21%Shares Changed QoQ

381No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Arrowhead Pharmaceuticals, Inc. (NASDAQ:ARWR) currently has 381 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The percentage of Arrowhead Pharmaceuticals owned by institutions changed from 68.2% in September 2025 to 87.0% in December 2025, marking a slight up trend.
Institutional share ownership changed by 5.21% QoQ, while the number of institutional owners saw an increase of 41.64% YoY.
A review of institutional activity for Arrowhead Pharmaceuticals shows 239 of 381 filers increasing their positions, while 106 reduced their stake, and 36 remained unchanged.
This class of investors increased its holdings in Arrowhead Pharmaceuticals to 114.97Mn shares for the 13F-cycle ending December 2025, up by 5.69Mn shares quarter on quarter, and up 14.92Mn shares year over year.
As of December 31, 2025, BlackRock, Inc. held Arrowhead Pharmaceuticals's largest shareholding position with over 21.32Mn shares, representing 16.13% of total outstanding shares.
Among the most significant buyers of Arrowhead Pharmaceuticals during December 2025 were NORGES BANK (1.70Mn), FRED ALGER MANAGEMENT, LLC (1.53Mn), BlackRock, Inc. (1.09Mn), Vestal Point Capital, LP (900.00K), DEERFIELD MANAGEMENT COMPANY, L.P. (839.95K).
Leading sellers of Arrowhead Pharmaceuticals stock in December 2025 included Slate Path Capital LP (2.46Mn), MARSHALL WACE, LLP (1.31Mn), Siren, L.L.C. (1.17Mn), VANGUARD GROUP INC (742.75K), Woodline Partners LP (599.97K).
The top 10 institutional holders of Arrowhead Pharmaceuticals for the quarter ending December 2025 included BlackRock, Inc. (21.32Mn), VANGUARD GROUP INC (15.29Mn), Avoro Capital Advisors LLC (10.62Mn), FMR LLC (6.52Mn), STATE STREET CORP (6.40Mn), GEODE CAPITAL MANAGEMENT, LLC (3.26Mn), Slate Path Capital LP (2.52Mn), BAKER BROS. ADVISORS LP (2.18Mn), ARROWSTREET CAPITAL, LIMITED PARTNERSHIP (2.09Mn), FRED ALGER MANAGEMENT, LLC (1.83Mn).

381 Institutional Holders

1,198,599 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	21,318,582	1,093,757	5.41%	$1,415,340,659.00
VANGUARD GROUP INC	31 Dec, 2025	15,293,121	-742,749	-4.63%	$1,015,310,304.00
Avoro Capital Advisors LLC	31 Dec, 2025	10,625,000	-275,000	-2.52%	$705,393,750.00
FMR LLC	31 Dec, 2025	6,520,408	760,578	13.20%	$432,889,919.00
STATE STREET CORP	31 Dec, 2025	6,403,830	6,466	0.10%	$425,150,274.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	3,264,963	133,921	4.28%	$216,798,525.00
Slate Path Capital LP	31 Dec, 2025	2,523,500	-2,458,500	-49.35%	$167,535,165.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	2,175,645	504,883	30.22%	$144,441,072.00
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	31 Dec, 2025	2,087,953	6,264	0.30%	$138,619,200.00
FRED ALGER MANAGEMENT, LLC	31 Dec, 2025	1,832,997	1,526,164	497.39%	$121,692,671.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	1,832,946	839,946	84.59%	$121,689,285.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,769,340	-330,058	-15.72%	$117,466,483.00
NORGES BANK	31 Dec, 2025	1,704,464	1,704,464	0.00%	$113,159,365.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	1,687,522	-136,056	-7.46%	$112,034,585.00
Siren, L.L.C.	31 Dec, 2025	1,500,476	-1,169,404	-43.80%	$99,616,602.00
MORGAN STANLEY	31 Dec, 2025	1,476,005	-226,669	-13.31%	$97,992,146.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	1,353,719	7,859	0.58%	$89,873,404.00
NORTHERN TRUST CORP	31 Dec, 2025	1,346,257	34,667	2.64%	$89,378,003.00
Fisher Asset Management, LLC	31 Dec, 2025	1,311,727	257,933	24.48%	$87,085,554.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	1,280,446	306,879	31.52%	$84,997,093.00

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