Amylyx Pharmaceuticals, Inc. (AMLX) Insider Ownership

Historic Insider Ownership Trends

As of March 23, 2026, the three largest insider holders of AMLX are Venture Investments Ltd Morningside (TenPercentOwner, 10.68Mn shares), Isaac Cheng (Director, 10.42Mn shares), Invest 1 B.V. Als (TenPercentOwner, 5.90Mn shares).

Top Direct Holders

Insider ownership data is derived from the last 60 months of Form 4 SEC filings.
Holder Position Shares (Direct) Shares (Indirect) Report Date
Venture Investments Ltd Morningside 0 10,678,808 17 Mar, 2022
Isaac Cheng 6,578 10,415,650 10 Jan, 2022
Invest 1 B.V. Als 5,895,280 0 08 Jul, 2022
Venture Investments Ltd Morningside 4,997,302 0 17 Aug, 2023
Joshua B Cohen Co Chief Executive Officer 3,583,548 0 09 Mar, 2026
Justin B. Klee Co Chief Executive Officer 3,583,481 0 09 Mar, 2026
Global Investors Lp Viking 0 1,850,940 09 Sep, 2022
George M Jr Milne 812,881 0 14 Jan, 2026
Margaret Olinger Chief Commercial Officer 276,108 0 29 Dec, 2023
Camille L Bedrosian Chief Medical Officer 265,285 0 09 Mar, 2026
James M Frates Chief Financial Officer 261,628 0 09 Mar, 2026
Gina Mazzariello Chief Legal Officer 209,090 0 09 Mar, 2026
Patrick D Yeramian Chief Medical Officer 205,605 0 11 Jan, 2024
Karen Firestone 63,100 0 23 Dec, 2025
James M Frates Chief Financial Officer 0 11,072 02 Nov, 2023
Bernhardt G Zeiher 10,000 0 24 Mar, 2025
Daphne Quimi 5,000 0 16 May, 2024
Paul R. Fonteyne 3,947 0 10 Jan, 2022

* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.

Recent Insider Transactions

Detailed insider trading activity based on Form 4 SEC filings.
Download Data
Transaction Date Insider Name Security Class Transaction Type Shares Traded Price Shares Remaining Ownership Code
05 Mar, 2026 Joshua B Cohen Common Stock A 248,865 $0.00 3,583,548 D A
05 Mar, 2026 Camille L Bedrosian Common Stock A 95,990 $0.00 265,285 D A
05 Mar, 2026 Gina Mazzariello Common Stock A 74,660 $0.00 209,090 D A
05 Mar, 2026 James M Frates Common Stock A 95,990 $0.00 261,628 D A
05 Mar, 2026 Justin B. Klee Common Stock A 248,865 $0.00 3,583,481 D A
05 Mar, 2026 Gina Mazzariello Stock Option (Right to Buy) A 111,990 $0.00 111,990 D A
05 Mar, 2026 Camille L Bedrosian Stock Option (Right to Buy) A 143,985 $0.00 143,985 D A
05 Mar, 2026 Joshua B Cohen Stock Option (Right to Buy) A 373,295 $0.00 373,295 D A
05 Mar, 2026 Justin B. Klee Stock Option (Right to Buy) A 373,295 $0.00 373,295 D A
05 Mar, 2026 James M Frates Stock Option (right to buy) A 143,985 $0.00 143,985 D A
02 Mar, 2026 Gina Mazzariello Common Stock D 6,844 $14.52 134,430 D S
02 Mar, 2026 Justin B. Klee Common Stock D 29,282 $14.47 3,334,616 D S
02 Mar, 2026 Joshua B Cohen Common Stock D 29,282 $14.48 3,334,683 D S
02 Mar, 2026 Camille L Bedrosian Common Stock D 6,461 $14.58 169,295 D S
02 Mar, 2026 James M Frates Common Stock D 7,909 $14.52 165,638 D S
23 Feb, 2026 Gina Mazzariello Common Stock D 3,419 $14.14 141,274 D S
02 Feb, 2026 Justin B. Klee Common Stock D 15,500 $14.69 3,363,898 D S
02 Feb, 2026 Gina Mazzariello Common Stock D 3,448 $14.65 144,693 D S
02 Feb, 2026 Joshua B Cohen Common Stock D 15,500 $14.68 3,363,965 D S
02 Feb, 2026 James M Frates Common Stock D 3,557 $14.65 173,547 D S