As of June 06, 2026, Amylyx Pharmaceuticals's top three insider holders are Venture Investments Ltd Morningside (TenPercentOwner, 21.09Mn shares), Isaac Cheng (Director, 10.42Mn shares), Invest 1 B.V. Als (TenPercentOwner, 5.90Mn shares).
| Holder | Position | Shares (Direct) | Shares (Indirect) | Report Date |
|---|---|---|---|---|
| Global Investors Lp Viking | - | 0 | 1,850,940 | 09 Sep, 2022 |
| George M Jr Milne | - | 812,881 | 0 | 14 Jan, 2026 |
| Camille L Bedrosian | Chief Medical Officer | 265,285 | 0 | 09 Mar, 2026 |
| Patrick D Yeramian | Chief Medical Officer | 205,605 | 0 | 11 Jan, 2024 |
| Daphne Quimi | - | 5,000 | 0 | 16 May, 2024 |
| Venture Investments Ltd Morningside | - | 0 | 21,094,458 | 17 Mar, 2022 |
| Isaac Cheng | - | 6,578 | 10,415,650 | 10 Jan, 2022 |
| Justin B. Klee | Co Chief Executive Officer | 3,583,481 | 0 | 09 Mar, 2026 |
| Joshua B Cohen | Co Chief Executive Officer | 3,583,548 | 0 | 09 Mar, 2026 |
| Margaret Olinger | Chief Commercial Officer | 276,108 | 0 | 29 Dec, 2023 |
| Gina Mazzariello | Chief Legal Officer | 209,090 | 0 | 09 Mar, 2026 |
| Invest 1 B.V. Als | - | 5,895,280 | 0 | 08 Jul, 2022 |
| Karen Firestone | - | 63,100 | 0 | 23 Dec, 2025 |
| Bernhardt G Zeiher | - | 10,000 | 0 | 24 Mar, 2025 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 05 Mar, 2026 | Gina Mazzariello | Common Stock | A | 74,660 | $0.00 | 209,090 | D | A |
| 05 Mar, 2026 | Justin B. Klee | Common Stock | A | 248,865 | $0.00 | 3,583,481 | D | A |
| 05 Mar, 2026 | Gina Mazzariello | Common Stock | A | 74,660 | $0.00 | 209,090 | D | A |
| 05 Mar, 2026 | Justin B. Klee | Common Stock | A | 248,865 | $0.00 | 3,583,481 | D | A |
| 05 Mar, 2026 | Joshua B Cohen | Common Stock | A | 248,865 | $0.00 | 3,583,548 | D | A |
| 05 Mar, 2026 | Joshua B Cohen | Common Stock | A | 248,865 | $0.00 | 3,583,548 | D | A |
| 05 Mar, 2026 | Camille L Bedrosian | Common Stock | A | 95,990 | $0.00 | 265,285 | D | A |
| 05 Mar, 2026 | Camille L Bedrosian | Stock Option (Right to Buy) | A | 143,985 | $0.00 | 143,985 | D | A |
| 05 Mar, 2026 | Justin B. Klee | Stock Option (Right to Buy) | A | 373,295 | $0.00 | 373,295 | D | A |
| 05 Mar, 2026 | Justin B. Klee | Stock Option (Right to Buy) | A | 373,295 | $0.00 | 373,295 | D | A |
| 05 Mar, 2026 | Joshua B Cohen | Stock Option (Right to Buy) | A | 373,295 | $0.00 | 373,295 | D | A |
| 05 Mar, 2026 | Gina Mazzariello | Stock Option (Right to Buy) | A | 111,990 | $0.00 | 111,990 | D | A |
| 05 Mar, 2026 | Joshua B Cohen | Stock Option (Right to Buy) | A | 373,295 | $0.00 | 373,295 | D | A |
| 05 Mar, 2026 | Gina Mazzariello | Stock Option (Right to Buy) | A | 111,990 | $0.00 | 111,990 | D | A |
| 02 Mar, 2026 | Justin B. Klee | Common Stock | D | 29,282 | $14.47 | 3,334,616 | D | S |
| 02 Mar, 2026 | Gina Mazzariello | Common Stock | D | 6,844 | $14.52 | 134,430 | D | S |
| 02 Mar, 2026 | Justin B. Klee | Common Stock | D | 29,282 | $14.47 | 3,334,616 | D | S |
| 02 Mar, 2026 | Joshua B Cohen | Common Stock | D | 29,282 | $14.48 | 3,334,683 | D | S |
| 02 Mar, 2026 | Gina Mazzariello | Common Stock | D | 6,844 | $14.52 | 134,430 | D | S |
| 02 Mar, 2026 | Joshua B Cohen | Common Stock | D | 29,282 | $14.48 | 3,334,683 | D | S |