Data spanning the past 90 days through January 10, 2026 reveals that Amylyx Pharmaceuticals's three principal insider shareholders consist of TenPercentOwner Venture Investments Ltd Morningside (15.68Mn shares), Director Isaac Cheng (10.42Mn shares), TenPercentOwner Invest 1 B.V. Als (5.90Mn shares).
| Holder | Position | Shares | Report Date |
|---|---|---|---|
| Venture Investments Ltd Morningside | 15,676,110 | 17 Aug, 2023 | |
| Isaac Cheng | 10,422,228 | 10 Jan, 2022 | |
| Invest 1 B.V. Als | 5,895,280 | 08 Jul, 2022 | |
| Joshua B Cohen | Co Chief Executive Officer | 3,317,632 | 08 Jan, 2026 |
| Justin B. Klee | Co Chief Executive Officer | 3,317,586 | 08 Jan, 2026 |
| Global Investors Lp Viking | 1,850,940 | 09 Sep, 2022 | |
| George M Jr Milne | 830,661 | 28 Jan, 2025 | |
| Margaret Olinger | Chief Commercial Officer | 276,108 | 29 Dec, 2023 |
| Patrick D Yeramian | Chief Medical Officer | 205,605 | 11 Jan, 2024 |
| James M Frates | Chief Financial Officer | 188,176 | 08 Jan, 2026 |
| Camille L Bedrosian | Chief Medical Officer | 175,756 | 03 Dec, 2025 |
| Gina Mazzariello | Chief Legal Officer | 148,141 | 02 Oct, 2025 |
| Karen Firestone | 63,100 | 23 Dec, 2025 | |
| Bernhardt G Zeiher | 10,000 | 24 Mar, 2025 | |
| Daphne Quimi | 5,000 | 16 May, 2024 | |
| Paul R. Fonteyne | 3,947 | 10 Jan, 2022 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 06 Jan, 2026 | James M Frates | Common Stock | D | 3,326 | $11.11 | 177,104 | D | S |
| 06 Jan, 2026 | Justin B. Klee | Common Stock | D | 7,715 | $11.09 | 3,317,586 | D | S |
| 06 Jan, 2026 | Joshua B Cohen | Common Stock | D | 7,715 | $11.09 | 3,317,632 | D | S |
| 23 Dec, 2025 | Karen Firestone | - | - | 63,100 | D | |||
| 23 Dec, 2025 | Karen Firestone | Common Stock | A | 8,100 | $12.45 | 63,100 | D | P |
| 01 Dec, 2025 | Camille L Bedrosian | Common Stock | D | 6,580 | $14.35 | 175,756 | D | S |
| 01 Dec, 2025 | Camille L Bedrosian | - | - | 175,756 | D | |||
| 30 Sep, 2025 | James M Frates | - | - | 280,430 | D | |||
| 30 Sep, 2025 | James M Frates | Common Stock | D | 10,558 | $14.65 | 280,430 | D | S |
| 30 Sep, 2025 | Camille L Bedrosian | Common Stock | D | 12,039 | $14.58 | 182,336 | D | S |
| 30 Sep, 2025 | Justin B. Klee | Common Stock | D | 29,775 | $14.37 | 3,325,501 | D | S |
| 30 Sep, 2025 | Justin B. Klee | - | - | 3,325,301 | D | |||
| 30 Sep, 2025 | Justin B. Klee | Common Stock | D | 200 | $15.01 | 3,325,301 | D | S |
| 30 Sep, 2025 | Joshua B Cohen | Common Stock | D | 29,733 | $14.34 | 3,325,547 | D | S |
| 30 Sep, 2025 | Joshua B Cohen | Common Stock | D | 200 | $15.00 | 3,325,347 | D | S |
| 30 Sep, 2025 | Gina Mazzariello | Common Stock | D | 8,828 | $14.58 | 148,141 | D | S |
| 13 Aug, 2025 | Gina Mazzariello | Common Stock | D | 15,000 | $8.34 | 156,969 | D | S |
| 13 Aug, 2025 | Gina Mazzariello | - | - | 156,969 | D | |||
| 12 Aug, 2025 | Gina Mazzariello | Common Stock | D | 15,000 | $8.07 | 171,969 | D | S |
| 12 Aug, 2025 | Gina Mazzariello | - | - | 171,969 | D |