Amylyx Pharmaceuticals's top three insider shareholders as of April 17, 2026 are Venture Investments Ltd Morningside (TenPercentOwner, 21.09Mn shares), Isaac Cheng (Director, 10.42Mn shares), Invest 1 B.V. Als (TenPercentOwner, 5.90Mn shares).
| Holder | Position | Shares (Direct) | Shares (Indirect) | Report Date |
|---|---|---|---|---|
| Venture Investments Ltd Morningside | - | 0 | 21,094,458 | 17 Mar, 2022 |
| Isaac Cheng | - | 6,578 | 10,415,650 | 10 Jan, 2022 |
| Invest 1 B.V. Als | - | 5,895,280 | 0 | 08 Jul, 2022 |
| Venture Investments Ltd Morningside | - | 4,997,302 | 0 | 17 Aug, 2023 |
| Joshua B Cohen | Co Chief Executive Officer | 3,583,548 | 0 | 09 Mar, 2026 |
| Justin B. Klee | Co Chief Executive Officer | 3,583,481 | 0 | 09 Mar, 2026 |
| Global Investors Lp Viking | - | 0 | 1,850,940 | 09 Sep, 2022 |
| George M Jr Milne | - | 812,881 | 0 | 14 Jan, 2026 |
| Margaret Olinger | Chief Commercial Officer | 276,108 | 0 | 29 Dec, 2023 |
| Gina Mazzariello | Chief Legal Officer | 209,090 | 0 | 09 Mar, 2026 |
| Patrick D Yeramian | Chief Medical Officer | 205,605 | 0 | 11 Jan, 2024 |
| Karen Firestone | - | 63,100 | 0 | 23 Dec, 2025 |
| Bernhardt G Zeiher | - | 10,000 | 0 | 24 Mar, 2025 |
| Daphne Quimi | - | 5,000 | 0 | 16 May, 2024 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 05 Mar, 2026 | Justin B. Klee | Common Stock | A | 248,865 | $0.00 | 3,583,481 | D | A |
| 05 Mar, 2026 | Gina Mazzariello | Common Stock | A | 74,660 | $0.00 | 209,090 | D | A |
| 05 Mar, 2026 | Camille L Bedrosian | Common Stock | A | 95,990 | $0.00 | 265,285 | D | A |
| 05 Mar, 2026 | Joshua B Cohen | Common Stock | A | 248,865 | $0.00 | 3,583,548 | D | A |
| 05 Mar, 2026 | Camille L Bedrosian | Stock Option (Right to Buy) | A | 143,985 | $0.00 | 143,985 | D | A |
| 05 Mar, 2026 | Justin B. Klee | Stock Option (Right to Buy) | A | 373,295 | $0.00 | 373,295 | D | A |
| 05 Mar, 2026 | Joshua B Cohen | Stock Option (Right to Buy) | A | 373,295 | $0.00 | 373,295 | D | A |
| 05 Mar, 2026 | Gina Mazzariello | Stock Option (Right to Buy) | A | 111,990 | $0.00 | 111,990 | D | A |
| 02 Mar, 2026 | Justin B. Klee | Common Stock | D | 29,282 | $14.47 | 3,334,616 | D | S |
| 02 Mar, 2026 | Joshua B Cohen | Common Stock | D | 29,282 | $14.48 | 3,334,683 | D | S |
| 02 Mar, 2026 | Gina Mazzariello | Common Stock | D | 6,844 | $14.52 | 134,430 | D | S |
| 02 Mar, 2026 | Camille L Bedrosian | Common Stock | D | 6,461 | $14.58 | 169,295 | D | S |
| 23 Feb, 2026 | Gina Mazzariello | Common Stock | D | 3,419 | $14.14 | 141,274 | D | S |
| 02 Feb, 2026 | Gina Mazzariello | Common Stock | D | 3,448 | $14.65 | 144,693 | D | S |
| 02 Feb, 2026 | Justin B. Klee | Common Stock | D | 15,500 | $14.69 | 3,363,898 | D | S |
| 02 Feb, 2026 | Joshua B Cohen | Common Stock | D | 15,500 | $14.68 | 3,363,965 | D | S |
| 15 Jan, 2026 | Joshua B Cohen | Common Stock | A | 197,182 | $7.57 | 3,514,814 | D | M |
| 15 Jan, 2026 | Justin B. Klee | Common Stock | A | 197,153 | $7.57 | 3,514,739 | D | M |
| 15 Jan, 2026 | Justin B. Klee | Common Stock | D | 136,193 | $13.58 | 3,378,546 | D | S |
| 15 Jan, 2026 | Joshua B Cohen | Common Stock | D | 136,193 | $13.59 | 3,378,621 | D | S |