Amylyx Pharmaceuticals, Inc. (AMLX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

83,397,765Shares Outstanding

7,240,098Shares held by institutions

$102,302,585Value of institutional holdings

133.98%Institutional ownership %

7.57%Shares Changed QoQ

173No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Amylyx Pharmaceuticals, Inc. (NASDAQ:AMLX) includes 173 filers as of the latest reporting cycle ending December 2025.

Amylyx Pharmaceuticals saw its institutional ownership percentage fell to 134.0% in December 2025 from 134.2% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 7.57%, with a year-over-year an increase of 40.65% in the count of filers.
During the quarter, 109 institutions bought more Amylyx Pharmaceuticals shares, 42 sold shares, and 22 of the 173 total investors held their position steady.
Collectively, institutional investors increased their stake in Amylyx Pharmaceuticals to 111.74Mn shares as of December 2025, a change that is up by 7.86Mn shares quarter on quarter and up 61.94Mn shares year over year.
FMR LLC's holding of 16.52Mn shares as of December 31, 2025 makes it the primary institutional investor in Amylyx Pharmaceuticals, owning 19.81% of the stock.
Among the most significant buyers of Amylyx Pharmaceuticals during December 2025 were FMR LLC (5.14Mn), JANUS HENDERSON GROUP PLC (1.93Mn), BlackRock, Inc. (1.91Mn), Commodore Capital LP (1.57Mn), FRANKLIN RESOURCES INC (1.20Mn).
Leading sellers of Amylyx Pharmaceuticals stock in December 2025 included ADAGE CAPITAL PARTNERS GP, L.L.C. (4.04Mn), Point72 Asset Management, L.P. (2.46Mn), Almitas Capital LLC (2.12Mn), UBS Group AG (861.15K), PERCEPTIVE ADVISORS LLC (667.48K).
The top 10 institutional holders of Amylyx Pharmaceuticals for the quarter ending December 2025 included FMR LLC (16.52Mn), BlackRock, Inc. (9.05Mn), PERCEPTIVE ADVISORS LLC (8.28Mn), TCG Crossover Management, LLC (6.24Mn), VANGUARD GROUP INC (5.80Mn), Commodore Capital LP (5.65Mn), Saturn V Capital Management LP (4.50Mn), JANUS HENDERSON GROUP PLC (4.47Mn), First Light Asset Management, LLC (3.36Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (3.11Mn).

173 Institutional Holders

7,240,098 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	16,518,419	5,139,212	45.16%	$199,542,502.00
BlackRock, Inc.	31 Dec, 2025	9,054,431	1,913,739	26.80%	$109,377,525.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	8,284,882	-667,483	-7.46%	$100,081,375.00
TCG Crossover Management, LLC	31 Dec, 2025	6,243,812	0	0.00%	$75,425,249.00
VANGUARD GROUP INC	31 Dec, 2025	5,804,912	531,162	10.07%	$70,123,336.00
Commodore Capital LP	31 Dec, 2025	5,650,000	1,574,522	38.63%	$68,252,000.00
Saturn V Capital Management LP	31 Dec, 2025	4,496,487	-108,391	-2.35%	$54,317,563.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	4,465,872	1,929,639	76.08%	$53,992,392.00
First Light Asset Management, LLC	31 Dec, 2025	3,355,539	-343	-0.01%	$40,534,911.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	3,109,503	688,736	28.45%	$37,562,796.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	2,777,055	-4,039,773	-59.26%	$33,546,824.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	2,613,221	602,588	29.97%	$31,567,709.00
MORGAN STANLEY	31 Dec, 2025	2,359,824	409,523	21.00%	$28,506,673.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	2,165,534	353,495	19.51%	$26,163,536.00
Almitas Capital LLC	31 Dec, 2025	2,122,597	-2,122,597	-50.00%	$25,640,972.00
STATE STREET CORP	31 Dec, 2025	2,069,884	448,624	27.67%	$25,004,199.00
GREAT POINT PARTNERS LLC	31 Dec, 2025	1,750,000	50,000	2.94%	$21,140,000.00
683 Capital Management, LLC	31 Dec, 2025	1,650,000	-110,000	-6.25%	$19,932,000.00
EVENTIDE ASSET MANAGEMENT, LLC	31 Dec, 2025	1,513,148	648	0.04%	$18,278,773.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	1,336,010	906,494	211.05%	$16,139,001.00

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