Amylyx Pharmaceuticals, Inc. (AMLX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

93,332,930Shares Outstanding

115,353,432Shares held by institutions

$2,045,793,117Value of institutional holdings

123.59%Institutional ownership %

7.08%Shares Changed QoQ

176No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Amylyx Pharmaceuticals, Inc. (NASDAQ:AMLX) has 176 institutional investors that have filed 13F reports for the period ending December 2025.

Their combined ownership stood at 120.8% of outstanding shares in December 2025, down from 121.3% in September 2025.
They increased total shares held in Amylyx Pharmaceuticals by 5.13% from the prior quarter, while the number of investors in AMLX increased 44.26% year over year.
Among the 176 funds, 108 bought more Amylyx Pharmaceuticals shares, 48 sold down, and 20 held their ground.
Institutional investors collectively held 112.73Mn shares in Amylyx Pharmaceuticals as of December 2025, up by 5.51Mn shares quarter on quarter, and up 61.44Mn shares year over year.
FMR LLC holds the largest position in AMLX at 16.52Mn shares as of December 31, 2025, or 17.7% of shares outstanding.
The biggest buyers of Amylyx Pharmaceuticals for the quarter ending December 2025 included FMR LLC (5.14Mn), Goldman Sachs Group Inc (3.22Mn), Janus Henderson Group Plc (1.93Mn), BlackRock, Inc. (1.91Mn), Commodore Capital LP (1.57Mn).
The largest sellers of Amylyx Pharmaceuticals for the quarter ending December 2025 were ADAGE CAPITAL PARTNERS GP, L.L.C. (4.04Mn), Point72 Asset Management, L.P. (2.46Mn), Almitas Capital LLC (2.12Mn), T. Rowe Price Investment Management, Inc. (1.19Mn), Boxer Capital Management, LLC (1.0Mn).
Amylyx Pharmaceuticals's 10 largest shareholders as of December 2025 include FMR LLC (16.52Mn), BlackRock, Inc. (9.05Mn), PERCEPTIVE ADVISORS LLC (8.28Mn), TCG Crossover Management, LLC (6.24Mn), VANGUARD GROUP INC (5.8Mn), Commodore Capital LP (5.65Mn), Goldman Sachs Group Inc (5.23Mn), Saturn V Capital Management LP (4.5Mn), Janus Henderson Group Plc (4.47Mn), First Light Asset Management, LLC (3.36Mn) per Business Quant data.

176 Institutional Holders

115,353,432 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	16,518,419	5,139,212	45.16%	$199,542,502.00
BlackRock, Inc.	31 Dec, 2025	9,054,431	1,913,739	26.80%	$109,377,525.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	8,284,882	-667,483	-7.46%	$100,081,375.00
TCG Crossover Management, LLC	31 Dec, 2025	6,243,812	0	0.00%	$75,425,249.00
VANGUARD GROUP INC	31 Dec, 2025	5,804,912	531,162	10.07%	$70,123,336.00
Commodore Capital LP	31 Dec, 2025	5,650,000	1,574,522	38.63%	$68,252,000.00
Goldman Sachs Group Inc	31 Dec, 2025	5,226,442	3,215,809	159.94%	$63,135,418.00
Saturn V Capital Management LP	31 Dec, 2025	4,496,487	-108,391	-2.35%	$54,317,563.00
Janus Henderson Group Plc	31 Dec, 2025	4,465,872	1,929,639	76.08%	$53,992,392.00
First Light Asset Management, LLC	31 Dec, 2025	3,355,539	-343	-0.01%	$40,534,911.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	3,109,503	688,736	28.45%	$37,562,796.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	2,777,055	-4,039,773	-59.26%	$33,546,824.00
Morgan Stanley	31 Dec, 2025	2,359,824	409,523	21.00%	$28,506,673.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	2,165,534	353,495	19.51%	$26,163,536.00
Almitas Capital LLC	31 Dec, 2025	2,122,597	-2,122,597	-50.00%	$25,640,972.00
State Street Corp	31 Dec, 2025	2,069,884	448,624	27.67%	$25,004,199.00
ADAR1 Capital Management, LLC	31 Dec, 2025	1,780,712	914,510	105.58%	$21,511,000.00
GREAT POINT PARTNERS LLC	31 Dec, 2025	1,750,000	50,000	2.94%	$21,140,000.00
683 Capital Management, LLC	31 Dec, 2025	1,650,000	-110,000	-6.25%	$19,932,000.00
EVENTIDE ASSET MANAGEMENT, LLC	31 Dec, 2025	1,513,148	648	0.04%	$18,278,773.00

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