Amylyx Pharmaceuticals, Inc. (AMLX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

11,318,455Shares held by institutions

$144,649,855Value of institutional holdings

91.22%Institutional ownership %

-2.50%Shares Changed QoQ

128No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Amylyx Pharmaceuticals, Inc. (NASDAQ:AMLX) showed up in the 13F filings of 176 institutional investors as of December 2025.

They owned 120.8% of outstanding stock in December 2025, down from 121.3% the prior quarter.
Their total shares held in AMLX increased 5.13% from the prior quarter, while the number of investors in Amylyx Pharmaceuticals increased 44.26% year over year.
During the quarter, 108 of these 176 funds increased positions in AMLX, 48 reduced exposure, and 20 held steady.
Combined, these investors held 112.73Mn shares in AMLX for December 2025, up by 5.51Mn shares quarter on quarter, and up 61.44Mn shares year over year.
As of December 31, 2025, FMR LLC held the largest stake in Amylyx Pharmaceuticals with 16.52Mn shares, accounting for 17.7% of total shares outstanding.
Top purchasers of AMLX stock for the quarter ending December 2025 included FMR LLC (5.14Mn), Janus Henderson Group Plc (1.93Mn), BlackRock, Inc. (1.91Mn), Commodore Capital LP (1.57Mn), Franklin Resources Inc (1.2Mn).
The biggest sellers of Amylyx Pharmaceuticals for the quarter ending December 2025 included ADAGE CAPITAL PARTNERS GP, L.L.C. (4.04Mn), Point72 Asset Management, L.P. (2.46Mn), Almitas Capital LLC (2.12Mn), T. Rowe Price Investment Management, Inc. (1.19Mn), Boxer Capital Management, LLC (1.0Mn).
According to Business Quant data, leading holders of AMLX for December 2025 are FMR LLC (16.52Mn), BlackRock, Inc. (9.05Mn), PERCEPTIVE ADVISORS LLC (8.28Mn), TCG Crossover Management, LLC (6.24Mn), VANGUARD GROUP INC (5.8Mn), Commodore Capital LP (5.65Mn), Saturn V Capital Management LP (4.5Mn), Janus Henderson Group Plc (4.47Mn), First Light Asset Management, LLC (3.36Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (3.11Mn).

176 Institutional Holders

11,318,455 Total Shares Held

Rows:

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Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	1,913,739	26.80%	$0.00
FMR LLC	31 Dec, 2025	5,139,212	45.16%	$0.00
TCG Crossover Management, LLC	31 Dec, 2025	0	0.00%	$0.00
Barclays Plc	31 Dec, 2025	-203,507	-40.81%	$0.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	-667,483	-7.46%	$0.00
Commodore Capital LP	31 Dec, 2025	1,574,522	38.63%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	517	10,340.00%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	531,162	10.07%	$0.00
Saturn V Capital Management LP	31 Dec, 2025	-108,391	-2.35%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	1,929,639	76.08%	$0.00
ADAR1 Capital Management, LLC	31 Dec, 2025	914,510	105.58%	$0.00
First Light Asset Management, LLC	31 Dec, 2025	-343	-0.01%	$0.00
Logos Global Management LP	31 Dec, 2025	-500,000	-34.48%	$0.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	688,736	28.45%	$0.00
Woodline Partners LP	31 Dec, 2025	118	0.01%	$0.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	-4,039,773	-59.26%	$0.00
Boxer Capital Management, LLC	31 Dec, 2025	-1,000,000	-55.56%	$0.00
Goldman Sachs Group Inc	31 Dec, 2025	602,588	29.97%	$0.00
STEMPOINT CAPITAL LP	31 Dec, 2025	288,256	104.11%	$0.00
Morgan Stanley	31 Dec, 2025	409,523	21.00%	$0.00

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