As of September 26, 2026, the three largest insider holders of ALNY are John Maraganore (Chief Executive Officer, 227.66K shares), Yvonne Greenstreet (Chief Executive Officer, 95.80K shares), Jeffrey V. Poulton (Evp, Chief Financial Officer, 61.80K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | John Maraganore | Chief Executive Officer | 227,663 | 0 | 227,663 | 39.8% | 23 Dec, 2021 |
| 2 | Yvonne Greenstreet | Chief Executive Officer | 95,802 | 0 | 95,802 | 16.8% | 22 Sep, 2026 |
| 3 | Jeffrey V. Poulton | Evp, Chief Financial Officer | 61,805 | 0 | 61,805 | 10.8% | 06 Mar, 2026 |
| 4 | Tolga Tanguler | Evp, Chief Commercial Officer | 34,297 | 0 | 34,297 | 6.0% | 06 Mar, 2026 |
| 5 | Amy W Schulman | Director | 24,049 | 0 | 24,049 | 4.2% | 22 May, 2026 |
| 6 | Akshay Vaishnaw | President | 22,774 | 0 | 22,774 | 4.0% | 07 Aug, 2023 |
| 7 | Kevin Joseph Fitzgerald | Cso Evp, Head Of Research | 20,569 | 0 | 20,569 | 3.6% | 06 Mar, 2026 |
| 8 | Pushkal Garg | Evp Chief Rd | 18,693 | 0 | 18,693 | 3.3% | 06 Mar, 2026 |
| 9 | Michael W Bonney | Director | 16,804 | 0 | 16,804 | 2.9% | 19 Aug, 2025 |
| 10 | Bryan Supran | Evp, Clo And Secretary | 14,565 | 0 | 14,565 | 2.5% | 04 Mar, 2026 |
| 11 | Melissa Mclaughlin | Chief Human Resources Officer | 9,443 | 0 | 9,443 | 1.7% | 07 Apr, 2026 |
| 12 | Robert W. Hesslein | Evp, Clo And Secretary | 8,002 | 0 | 8,002 | 1.4% | 05 Mar, 2025 |
| 13 | Indrani Lall Franchini | Evp, Clo Secretary | 4,133 | 0 | 4,133 | 0.7% | 29 Feb, 2024 |
| 14 | David E I Pyott | Director | 1,582 | 0 | 1,582 | 0.3% | 03 Jun, 2026 |
| 15 | Dennis A Ausiello | Director | 1,582 | 0 | 1,582 | 0.3% | 22 May, 2026 |
| 16 | Margaret A Hamburg | Director | 1,582 | 0 | 1,582 | 0.3% | 22 May, 2026 |
| 17 | Charles Elliott Sigal | Director | 1,446 | 0 | 1,446 | 0.3% | 22 May, 2026 |
| 18 | Colleen F Reitan | Director | 1,446 | 0 | 1,446 | 0.3% | 22 May, 2026 |
| 19 | Olivier Brandicourt | Director | 1,446 | 0 | 1,446 | 0.3% | 22 May, 2026 |
| 20 | Peter N Kellogg | Director | 1,446 | 0 | 1,446 | 0.3% | 22 May, 2026 |
| 21 | Steven M Paul | Director | 1,000 | 0 | 1,000 | 0.2% | 05 Apr, 2022 |
| 22 | Carolyn R Bertozzi | Director | 775 | 0 | 775 | 0.1% | 12 May, 2025 |
| 23 | Stuart A Arbuckle | Director | 671 | 0 | 671 | 0.1% | 22 May, 2026 |
| 24 | Marsha Fanucci | Director | 136 | 0 | 136 | 0.0% | 27 Feb, 2023 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 19 Sep, 2026 | Yvonne Greenstreet | Chief Executive Officer | Acquired A | 107 | $0.00 | $0 | 95,802 | Direct |
| 01 Jun, 2026 | Benjamin Cravatt | Director | Acquired A | 4,393 | $0.00 | $0 | 4,393 | Direct |
| 01 Jun, 2026 | David E I Pyott | Director | Acquired M | 3,830 | $0.00 | $0 | 5,412 | Direct |
| 01 Jun, 2026 | David E I Pyott | Director | Disposed S | 921 | $297.71 | $274.19K | 4,491 | Direct |
| 01 Jun, 2026 | David E I Pyott | Director | Disposed S | 1,175 | $298.91 | $351.22K | 3,316 | Direct |
| 01 Jun, 2026 | David E I Pyott | Director | Disposed S | 1,222 | $299.87 | $366.44K | 2,094 | Direct |
| 01 Jun, 2026 | David E I Pyott | Director | Disposed S | 495 | $300.72 | $148.86K | 1,599 | Direct |
| 01 Jun, 2026 | David E I Pyott | Director | Disposed S | 17 | $302.65 | $5.15K | 1,582 | Direct |
| 01 Jun, 2026 | David E I Pyott | Director | Disposed M | 3,830 | $0.00 | $0 | 0 | Direct |
| 20 May, 2026 | Amy W Schulman | Director | Acquired A | 838 | $0.00 | $0 | 24,049 | Direct |
| 20 May, 2026 | Stuart A Arbuckle | Director | Acquired A | 671 | $0.00 | $0 | 671 | Direct |
| 20 May, 2026 | Margaret A Hamburg | Director | Acquired A | 671 | $0.00 | $0 | 1,582 | Direct |
| 20 May, 2026 | David E I Pyott | Director | Acquired A | 671 | $0.00 | $0 | 1,582 | Direct |
| 20 May, 2026 | Dennis A Ausiello | Director | Acquired A | 671 | $0.00 | $0 | 1,582 | Direct |
| 20 May, 2026 | Olivier Brandicourt | Director | Acquired A | 671 | $0.00 | $0 | 1,446 | Direct |
| 20 May, 2026 | Peter N Kellogg | Director | Acquired A | 671 | $0.00 | $0 | 1,446 | Direct |
| 20 May, 2026 | Colleen F Reitan | Director | Acquired A | 671 | $0.00 | $0 | 1,446 | Direct |
| 20 May, 2026 | Charles Elliott Sigal | Director | Acquired A | 671 | $0.00 | $0 | 1,446 | Direct |
| 20 May, 2026 | Stuart A Arbuckle | Director | Acquired A | 1,441 | $0.00 | $0 | 1,441 | Direct |
| 20 May, 2026 | Margaret A Hamburg | Director | Acquired A | 1,441 | $0.00 | $0 | 1,441 | Direct |