As of September 29, 2026, the three largest insider holders of AGIO are Brian Goff (Chief Executive Officer, 184.51K shares), Jacqualyn A Fouse (Chief Executive Officer, 154.16K shares), David P Schenkein (Chief Executive Officer, 126.24K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Brian Goff | Chief Executive Officer | 184,508 | 0 | 184,508 | 21.0% | 06 Apr, 2026 |
| 2 | Jacqualyn A Fouse | Chief Executive Officer | 154,156 | 0 | 154,156 | 17.6% | 23 Jun, 2026 |
| 3 | David P Schenkein | Chief Executive Officer | 126,242 | 0 | 126,242 | 14.4% | 17 Jun, 2024 |
| 4 | Cecilia Jones | Chief Financial Officer | 54,998 | 0 | 54,998 | 6.3% | 06 Apr, 2026 |
| 5 | Sarah Gheuens | Chief Medical Officer | 54,645 | 0 | 54,645 | 6.2% | 06 Aug, 2026 |
| 6 | James William Burns | Chief Legal Officer | 49,306 | 0 | 49,306 | 5.6% | 06 Apr, 2026 |
| 7 | Tsveta Milanova | Chief Commercial Officer | 46,829 | 0 | 46,829 | 5.3% | 06 Apr, 2026 |
| 8 | John Maraganore | Director | 30,028 | 0 | 30,028 | 3.4% | 24 May, 2022 |
| 9 | Jonathan Biller | Chief Financial Officer | 22,953 | 0 | 22,953 | 2.6% | 23 Feb, 2022 |
| 10 | David Scadden | Director | 20,419 | 0 | 20,419 | 2.3% | 23 Jun, 2026 |
| 11 | Maykin Ho | Director | 19,848 | 0 | 19,848 | 2.3% | 23 Jun, 2026 |
| 12 | Bruce Car | Chief Scientific Officer | 16,752 | 0 | 16,752 | 1.9% | 23 Feb, 2022 |
| 13 | Rahul D. Ballal | Director | 15,230 | 0 | 15,230 | 1.7% | 23 Jun, 2026 |
| 14 | Cynthia Smith | Director | 15,230 | 0 | 15,230 | 1.7% | 23 Jun, 2026 |
| 15 | Jeffrey D Capello | Director | 10,865 | 0 | 10,865 | 1.2% | 23 Jun, 2026 |
| 16 | Adams Catherine Owen | Director | 10,865 | 0 | 10,865 | 1.2% | 23 Jun, 2026 |
| 17 | Kaye I Foster-Cheek | Director | 10,284 | 0 | 10,284 | 1.2% | 23 Jun, 2026 |
| 18 | Krishnan Viswanadhan | Chief Corp Dev Strategy | 10,282 | 0 | 10,282 | 1.2% | 06 Apr, 2026 |
| 19 | Richa Poddar | Chief Commercial Officer | 8,508 | 0 | 8,508 | 1.0% | 18 Oct, 2022 |
| 20 | Ian T Clark | Director | 6,549 | 0 | 6,549 | 0.7% | 24 May, 2022 |
| 21 | Paul J Clancy | Director | 6,549 | 0 | 6,549 | 0.7% | 24 May, 2022 |
| 22 | Jay T. Backstrom | Director | 1,447 | 0 | 1,447 | 0.2% | 10 Jul, 2026 |
| 23 | Theodore James Jr. Washburn | Principal Accounting Officer | 868 | 0 | 868 | 0.1% | 05 Mar, 2026 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 04 Aug, 2026 | Sarah Gheuens | Chief Medical Officer | Disposed S | 30,000 | $30.48 | $914.40K | 54,645 | Direct |
| 08 Jul, 2026 | Jay T. Backstrom | Director | Acquired A | 1,447 | $0.00 | $0 | 1,447 | Direct |
| 08 Jul, 2026 | Jay T. Backstrom | Director | Disposed M | 1,447 | $0.00 | $0 | 2,894 | Direct |
| 01 Jul, 2026 | Sarah Gheuens | Chief Medical Officer | Acquired M | 8,375 | $0.00 | $0 | 88,652 | Direct |
| 01 Jul, 2026 | Sarah Gheuens | Chief Medical Officer | Disposed S | 4,007 | $37.56 | $150.50K | 84,645 | Direct |
| 01 Jul, 2026 | Sarah Gheuens | Chief Medical Officer | Disposed M | 8,375 | $0.00 | $0 | 0 | Direct |
| 18 Jun, 2026 | Jay T. Backstrom | Director | Acquired A | 2,927 | $0.00 | $0 | 2,927 | Direct |
| 18 Jun, 2026 | Kaye I Foster-Cheek | Director | Acquired M | 2,816 | $0.00 | $0 | 10,284 | Direct |
| 18 Jun, 2026 | Adams Catherine Owen | Director | Acquired M | 2,816 | $0.00 | $0 | 10,865 | Direct |
| 18 Jun, 2026 | Brian Goff | Chief Executive Officer | Disposed M | 39,000 | $0.00 | $0 | 39,000 | Direct |
| 18 Jun, 2026 | Krishnan Viswanadhan | Chief Strategy And Operations | Disposed M | 3,000 | $0.00 | $0 | 9,000 | Direct |
| 18 Jun, 2026 | Cynthia Smith | Director | Acquired M | 2,816 | $0.00 | $0 | 15,230 | Direct |
| 18 Jun, 2026 | Maykin Ho | Director | Acquired M | 2,816 | $0.00 | $0 | 19,848 | Direct |
| 18 Jun, 2026 | James William Burns | Chief Legal Officer | Disposed M | 3,000 | $0.00 | $0 | 9,000 | Direct |
| 18 Jun, 2026 | Jacqualyn A Fouse | Director | Acquired M | 2,816 | $0.00 | $0 | 154,156 | Direct |
| 18 Jun, 2026 | Jeffrey D Capello | Director | Acquired M | 2,816 | $0.00 | $0 | 10,865 | Direct |
| 18 Jun, 2026 | Rahul D. Ballal | Director | Acquired M | 2,816 | $0.00 | $0 | 15,230 | Direct |
| 18 Jun, 2026 | Cecilia Jones | Chief Financial Officer | Disposed M | 3,000 | $0.00 | $0 | 9,000 | Direct |
| 18 Jun, 2026 | David Scadden | Director | Acquired M | 2,816 | $0.00 | $0 | 20,419 | Direct |
| 18 Jun, 2026 | Sarah Gheuens | Chief Medical Officer | Disposed M | 3,000 | $0.00 | $0 | 9,000 | Direct |