Zymeworks (ZYME) Free Cash Flow (2021 - 2026)

Zymeworks' (ZYME) quarterly Free Cash Flow came in at -$45.8 million in Q1 2026, down 1238.53% year-on-year from $4.0 million in Q1 2025, and down 391.66% quarter-over-quarter from -$9.3 million in Q4 2025.

Zymeworks (ZYME) Free Cash Flow (2021 - 2026) Analysis & Trends

Zymeworks has disclosed Free Cash Flow across 6 years of filings, most recently posting -$45.8 million for Q1 2026.

  • Free Cash Flow for Q1 2026 came in at -$45.8 million, down 1238.53% year-over-year; the trailing twelve-month figure through Mar 2026 was -$75.4 million (up 0.54% YoY), and the FY2025 annual result was -$33.0 million, up 70.01% from the prior year.
  • Free Cash Flow came in at -$45.8 million for Q1 2026 at Zymeworks, down from -$9.3 million in the prior quarter.
  • In the past five years, Free Cash Flow ranged from a high of $320.6 million in Q4 2022 to a low of -$83.6 million in Q1 2023.
  • The 5-year median for Free Cash Flow is -$31.8 million (2025), against an average of -$10.2 million.
  • Across the five-year window, Free Cash Flow surged 679.9% in 2022 and sank 1238.53% in 2026, its largest moves.
  • Zymeworks' Free Cash Flow stood at $320.6 million in 2022, then sank by 95.77% to $13.6 million in 2023, then tumbled by 393.39% to -$39.8 million in 2024, then surged by 76.6% to -$9.3 million in 2025, then tumbled by 391.66% to -$45.8 million in 2026.
  • The last three Free Cash Flow figures came in at -$45.8 million (Q1 2026), -$9.3 million (Q4 2025), and -$31.8 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -1.67 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -12.20 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.49 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.29 Bn
9 Abivax 91.96 Bn 91.96 Bn - 63,220.27
10 Zymeworks 1.73 Bn 1.36 Bn - -45.82 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -45.82 Mn
Mar 31, 2026 -45.82 Mn
Dec 31, 2025 -9.32 Mn
Dec 31, 2025 -9.32 Mn
Sep 30, 2025 -31.82 Mn
Sep 30, 2025 -31.82 Mn
Jun 30, 2025 11.56 Mn
Jun 30, 2025 11.56 Mn
Mar 31, 2025 -3.42 Mn
Mar 31, 2025 -3.42 Mn
Dec 31, 2024 -39.83 Mn
Dec 31, 2024 -39.83 Mn
Sep 30, 2024 -6.78 Mn
Sep 30, 2024 -6.78 Mn
Jun 30, 2024 -25.77 Mn
Jun 30, 2024 -25.77 Mn
Mar 31, 2024 -37.68 Mn
Mar 31, 2024 -37.68 Mn
Dec 31, 2023 13.58 Mn
Dec 31, 2023 13.58 Mn