Zymeworks (ZYME) EBITDA Margin (2022 - 2026)
Zymeworks (ZYME) recorded EBITDA Margin of -894.27% in Q2 2026, down 898.00 percentage points from 3.73% a year earlier but up 1015.16 percentage points from the prior quarter.
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Analysis
Zymeworks (ZYME) EBITDA Margin (2022 - 2026) Analysis & Trends
On a TTM basis, Zymeworks' EBITDA Margin came in at -405.77% as of Jun 30, 2026, down 346.68 percentage points year-over-year; for FY2025, it came in at -80.05%, up 88.26 percentage points from FY2024.
- Annual EBITDA Margin has a five-year change of +381.95 percentage points (FY2020 to FY2025).
- Across earlier years, EBITDA Margin came in at -168.31% in FY2024 (-0.06 pp), -168.25% in FY2023 (-201.65 pp), 33.40% in FY2022 (+817.14 pp) and -783.74% in FY2021 (-321.74 pp).
- Quarterly EBITDA Margin has ranged from -3664.93% in Q1 2022 to 79.77% in Q4 2022 over the past five years.
- On a year-over-year basis, EBITDA Margin has declined for three consecutive quarters, with an average year-over-year change of -463.79 percentage points over the last eight quarters.
- Peak year-over-year performance for EBITDA Margin in the last five years was a gain of 3594.61 percentage points in Q1 2023, against a drop of 1824.53 percentage points in Q1 2026 at the low end.
- Per Business Quant, the preceding three quarters came in at -1909.43% (Q1 2026), -1712.49% (Q4 2025) and -74.44% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 645.01 Bn | 563.54 Bn | 17.26 Bn | 35.95% |
| 2 | AbbVie | 465.23 Bn | 438.39 Bn | 12.70 Bn | 49.01% |
| 3 | Merck | 368.40 Bn | 322.83 Bn | 12.21 Bn | 6.02% |
| 4 | Novartis Ag | 278.02 Bn | 233.89 Bn | 11.24 Bn | - |
| 5 | Astrazeneca | 254.57 Bn | 228.13 Bn | 12.86 Bn | 33.11% |
| 6 | Amgen | 229.02 Bn | 184.42 Bn | 7.24 Bn | 46.01% |
| 7 | Gilead Sciences | 187.74 Bn | 161.85 Bn | 6.22 Bn | -124.26% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 39.16% |
| 9 | Vertex Pharmaceuticals | 133.45 Bn | 105.45 Bn | 2.84 Bn | 39.10% |
| 10 | Zymeworks | 1.94 Bn | 826.25 Mn | - | -894.27% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -894.27% |
| Mar 31, 2026 | -1,909.43% |
| Dec 31, 2025 | -1,712.49% |
| Sep 30, 2025 | -74.44% |
| Jun 30, 2025 | 3.73% |
| Mar 31, 2025 | -84.89% |
| Dec 31, 2024 | -61.93% |
| Sep 30, 2024 | -201.19% |
| Jun 30, 2024 | -212.96% |
| Mar 31, 2024 | -359.31% |
| Dec 31, 2023 | -125.32% |
| Sep 30, 2023 | -182.75% |
| Jun 30, 2023 | -735.43% |
| Mar 31, 2023 | -70.32% |
| Dec 31, 2022 | 79.77% |
| Sep 30, 2022 | -1,855.07% |
| Jun 30, 2022 | -1,181.29% |
| Mar 31, 2022 | -3,664.93% |
API Access
Zymeworks EBITDA Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda-margin&ticker=ZYME&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda-margin", "ticker": "ZYME", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda-margin&ticker=ZYME&period=max&api_key=YOUR_API_KEY");
const data = await res.json();