Zymeworks (ZYME) EBITDA Margin (2021 - 2026)
Zymeworks recorded quarterly EBITDA Margin of 1854.15% in Q1 2026, down 13.08% quarter-over-quarter from 1639.68% in Q4 2025, and down 114157.0% year-over-year from N/an in Q1 2025.
Zymeworks' EBITDA Margin history runs 6 years deep, the most recent figure standing at 1854.15% for Q1 2026.
- In Q1 2026, EBITDA Margin fell 114157.0% year-over-year to 1854.15%; the TTM figure through Mar 2026 stood at 130.73% (up 6256.0% YoY), while the FY2025 annual figure was 75.74%, up 8552.0% from the prior year.
- EBITDA Margin came in at 1854.15% for Q1 2026 at Zymeworks, down from 1639.68% in the prior quarter.
- In the past five years, EBITDA Margin ranged from a high of 95.21% in Q4 2022 to a low of 3790.45% in Q1 2022.
- A 5-year average of 771.15% and a median of 326.76% in 2024 frame the typical range for EBITDA Margin.
- Across the five-year window, EBITDA Margin surged 372402 bps in 2023 and slumped 156086 bps in 2025, its largest moves.
- Zymeworks' EBITDA Margin stood at 95.21% in 2022, then tumbled by 179 bps to 75.55% in 2023, then fell by 4 bps to 78.82% in 2024, then slumped by 1980 bps to 1639.68% in 2025, then fell by 13 bps to 1854.15% in 2026.
- According to Business Quant data, EBITDA Margin over the past three periods registered 1854.15%, 1639.68%, and 77.25% for Q1 2026, Q4 2025, and Q3 2025 respectively.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 38.10% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 18.35% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 17.24% |
| 10 | Zymeworks | 1.84 Bn | 1.47 Bn | - | -1,854.15% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -1,854.15% |
| Dec 31, 2025 | -1,639.68% |
| Sep 30, 2025 | -77.25% |
| Jun 30, 2025 | 4.89% |
| Mar 31, 2025 | -712.58% |
| Dec 31, 2024 | -78.82% |
| Sep 30, 2024 | -174.66% |
| Jun 30, 2024 | -473.33% |
| Mar 31, 2024 | -326.76% |
| Dec 31, 2023 | -75.55% |
| Sep 30, 2023 | -176.74% |
| Jun 30, 2023 | -757.30% |
| Mar 31, 2023 | -66.43% |
| Dec 31, 2022 | 95.21% |
| Sep 30, 2022 | -1,818.55% |
| Jun 30, 2022 | -1,187.41% |
| Mar 31, 2022 | -3,790.45% |
| Dec 31, 2021 | -489.40% |
| Sep 30, 2021 | -1,378.36% |