Growth Metrics

Zymeworks (ZYME) Change in Cash (2021 - 2026)

Zymeworks recorded quarterly Change in Cash of $203.1 million in Q1 2026, up 957.9% quarter-over-quarter from -$23.7 million in Q4 2025, and up 1910.94% year-over-year from $10.1 million in Q1 2025.

Zymeworks' Change in Cash history runs 6 years deep, the most recent figure standing at $203.1 million for Q1 2026.

  • In Q1 2026, Change in Cash rose 1910.94% year-over-year to $203.1 million; the TTM figure through Mar 2026 stood at $168.1 million (up 535.32% YoY), while the FY2025 annual figure was -$24.9 million, up 72.72% from the prior year.
  • Change in Cash came in at $203.1 million for Q1 2026 at Zymeworks, up from -$23.7 million in the prior quarter.
  • In the past five years, Change in Cash ranged from a high of $304.8 million in Q4 2022 to a low of -$219.3 million in Q1 2023.
  • A 5-year average of $2.5 million and a median of -$33.4 million in 2025 frame the typical range for Change in Cash.
  • Across the five-year window, Change in Cash tumbled 397.8% in 2023 and surged 1910.94% in 2026, its largest moves.
  • Zymeworks' Change in Cash stood at $304.8 million in 2022, then tumbled by 79.26% to $63.2 million in 2023, then sank by 188.97% to -$56.3 million in 2024, then soared by 57.91% to -$23.7 million in 2025, then surged by 957.9% to $203.1 million in 2026.
  • According to Business Quant data, Change in Cash over the past three periods registered $203.1 million, -$23.7 million, and -$33.4 million for Q1 2026, Q4 2025, and Q3 2025 respectively.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 2.44 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 623.00 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -2.44 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 417.10 Mn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn -153.10 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 53.61 Mn
10 Zymeworks 1.84 Bn 1.47 Bn - 203.13 Mn

Historic Data

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DateValue
Mar 31, 2026 203.13 Mn
Dec 31, 2025 -23.68 Mn
Sep 30, 2025 -33.42 Mn
Jun 30, 2025 22.05 Mn
Mar 31, 2025 10.10 Mn
Dec 31, 2024 -56.25 Mn
Sep 30, 2024 51.39 Mn
Jun 30, 2024 -43.85 Mn
Mar 31, 2024 -42.74 Mn
Dec 31, 2023 63.23 Mn
Sep 30, 2023 -47.77 Mn
Jun 30, 2023 -39.48 Mn
Mar 31, 2023 -219.33 Mn
Dec 31, 2022 304.83 Mn
Sep 30, 2022 -102.57 Mn
Jun 30, 2022 -76.87 Mn
Mar 31, 2022 73.65 Mn
Dec 31, 2021 -51.57 Mn