Xenon Pharmaceuticals (XENE) Operating Income (2013 - 2026)

Xenon Pharmaceuticals (XENE) reported Operating Income of -$112.3 million for Q1 2026, down 54.43% year-over-year from -$246.5 million in Q1 2025, and down 2.33% quarter-over-quarter from -$109.8 million in Q4 2025.

Xenon Pharmaceuticals (XENE) Operating Income (2013 - 2026) Analysis & Trends

Xenon Pharmaceuticals (XENE) has 14 years of Operating Income data on file, last reported at -$112.3 million in Q1 2026.

  • Operating Income for Q1 2026 came in at -$112.3 million, down 54.43% year-over-year; the trailing twelve-month figure through Mar 2026 was -$412.7 million (down 40.84% YoY), and the FY2025 annual result was -$373.1 million, down 33.57% from the prior year.
  • Operating Income retreated to -$112.3 million in Q1 2026 per XENE's latest filing, from -$109.8 million in the prior quarter.
  • Over five years, Operating Income peaked at -$17.4 million in Q1 2022 and troughed at -$112.3 million in Q1 2026.
  • A 5-year average of -$65.2 million and a median of -$59.0 million in 2024 frame the typical range for Operating Income.
  • On a YoY basis, Operating Income climbed as much as 8.16% in 2022 and fell as far as 231.89% in 2022.
  • A 5-year view of Operating Income shows it stood at -$43.3 million in 2022, then retreated by 23.92% to -$53.7 million in 2023, then slumped by 44.29% to -$77.5 million in 2024, then slumped by 41.68% to -$109.8 million in 2025, then dropped by 2.33% to -$112.3 million in 2026.
  • Business Quant data shows XENE's Operating Income at -$112.3 million in Q1 2026, -$109.8 million in Q4 2025, and -$96.3 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -19.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.14 Bn
9 Abivax 91.96 Bn 91.96 Bn - -65.83 Mn
10 Xenon Pharmaceuticals 4.61 Bn 4.61 Bn - -112.33 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -112.33 Mn
Dec 31, 2025 -109.77 Mn
Sep 30, 2025 -96.34 Mn
Jun 30, 2025 -94.23 Mn
Mar 31, 2025 -72.74 Mn
Dec 31, 2024 -77.48 Mn
Sep 30, 2024 -73.68 Mn
Jun 30, 2024 -69.10 Mn
Mar 31, 2024 -59.04 Mn
Dec 31, 2023 -53.70 Mn
Sep 30, 2023 -55.68 Mn
Jun 30, 2023 -55.62 Mn
Mar 31, 2023 -49.05 Mn
Dec 31, 2022 -43.33 Mn
Sep 30, 2022 -38.13 Mn
Jun 30, 2022 -30.32 Mn
Mar 31, 2022 -17.37 Mn
Dec 31, 2021 32.86 Mn
Sep 30, 2021 -15.60 Mn
Jun 30, 2021 -22.50 Mn