Xenon Pharmaceuticals (XENE) EBITDA (2013 - 2026)

Xenon Pharmaceuticals' (XENE) quarterly EBITDA came in at -$112.3 million in Q1 2026, down 54.43% year-on-year from -$246.5 million in Q1 2025, and down 2.33% on a QoQ basis from -$109.8 million in Q4 2025.

Xenon Pharmaceuticals (XENE) EBITDA (2013 - 2026) Analysis & Trends

Xenon Pharmaceuticals (XENE) has 14 years of EBITDA data on file, last reported at -$112.3 million in Q1 2026.

  • On a quarterly basis, EBITDA fell 54.43% year-over-year to -$112.3 million in Q1 2026; TTM through Mar 2026 was -$412.7 million, a 40.84% decrease from a year earlier, with the FY2025 full-year figure at -$373.1 million, down 33.57% from the prior year.
  • EBITDA for Q1 2026 stood at -$112.3 million, down from -$109.8 million in the prior quarter.
  • Over the last five years, EBITDA for XENE reached as high as -$17.4 million in Q1 2022 and fell as low as -$112.3 million in Q1 2026.
  • Historically, EBITDA has averaged -$65.2 million across 5 years, with a median of -$59.0 million in 2024.
  • Across the five-year window, EBITDA slipped 8.16% in 2022 and plunged 182.41% in 2023, its largest moves.
  • Year by year, EBITDA stood at -$43.3 million in 2022, then dropped by 23.92% to -$53.7 million in 2023, then tumbled by 44.29% to -$77.5 million in 2024, then tumbled by 41.68% to -$109.8 million in 2025, then retreated by 2.33% to -$112.3 million in 2026.
  • Per Business Quant data, the three most recent EBITDA figures were -$112.3 million in Q1 2026, -$109.8 million in Q4 2025, and -$96.3 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -27.75 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 249.90 Mn
4 NuCana 279.75 Bn 279.75 Bn - -3.72 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -32.68 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 493.00 Mn
9 Revolution Medicines 37.78 Bn 37.78 Bn - -445.22 Mn
10 Xenon Pharmaceuticals 5.71 Bn 5.71 Bn - -112.33 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -112.33 Mn
Dec 31, 2025 -109.77 Mn
Sep 30, 2025 -96.34 Mn
Jun 30, 2025 -94.23 Mn
Mar 31, 2025 -72.74 Mn
Dec 31, 2024 -77.48 Mn
Sep 30, 2024 -73.68 Mn
Jun 30, 2024 -69.10 Mn
Mar 31, 2024 -59.04 Mn
Dec 31, 2023 -53.70 Mn
Sep 30, 2023 -55.68 Mn
Jun 30, 2023 -55.62 Mn
Mar 31, 2023 -49.05 Mn
Dec 31, 2022 -43.33 Mn
Sep 30, 2022 -38.13 Mn
Jun 30, 2022 -30.32 Mn
Mar 31, 2022 -17.37 Mn
Dec 31, 2021 -24.84 Mn
Sep 30, 2021 -15.60 Mn
Jun 30, 2021 -22.50 Mn