Upstream Bio (UPB) Non-cash Items (2023 - 2026)

Upstream Bio's quarterly Non-cash Items came in at $43.4 million in Q1 2026, up 1879.22% year-on-year from $2.2 million in Q1 2025, and down 73.26% quarter-over-quarter from $162.3 million in Q4 2025.

Upstream Bio has reported Non-cash Items for 4 years, with the latest figure at $43.4 million in Q1 2026.

  • For the quarter ending Q1 2026, Non-cash Items rose 1879.22% year-over-year to $43.4 million; the trailing twelve-month figure through Mar 2026 stood at $43.4 million (up 1879.22% YoY), and the FY2025 full-year result was $162.3 million, up 127.71% from the prior year.
  • Non-cash Items for Q1 2026 stood at $43.4 million, down from $162.3 million in the prior quarter.
  • The five-year high for Non-cash Items was $162.3 million in Q4 2025, with the low at $2.2 million in Q1 2025.
  • Average Non-cash Items over 4 years is $45.2 million, with a median of $37.4 million recorded in 2024.
  • Year-over-year, Non-cash Items slumped 90.39% in 2025 and soared 1879.22% in 2026.
  • Tracing UPB's Non-cash Items over 4 years: stood at $4.6 million in 2023, then soared by 1433.26% to $71.3 million in 2024, then jumped by 127.71% to $162.3 million in 2025, then slumped by 73.26% to $43.4 million in 2026.
  • The last three Non-cash Items figures came in at $43.4 million (Q1 2026), $162.3 million (Q4 2025), and $3.4 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn -
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn -
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn -
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn
7 Evaxion A 64.16 Bn 64.14 Bn -
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn
10 Upstream Bio 454.22 Mn 454.22 Mn -3.94 Mn

Historic Data

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DateValue
Mar 31, 2026 43.40 Mn
Mar 31, 2026 43.40 Mn
Dec 31, 2025 162.28 Mn
Dec 31, 2025 162.28 Mn
Sep 30, 2025 3.37 Mn
Sep 30, 2025 3.37 Mn
Jun 30, 2025 39.69 Mn
Jun 30, 2025 39.69 Mn
Mar 31, 2025 2.19 Mn
Mar 31, 2025 2.19 Mn
Dec 31, 2024 71.27 Mn
Dec 31, 2024 71.27 Mn
Sep 30, 2024 35.09 Mn
Sep 30, 2024 35.09 Mn
Dec 31, 2023 4.65 Mn
Dec 31, 2023 4.65 Mn