Upstream Bio (UPB) Net Income towards Common Stockholders (2023 - 2026)

Upstream Bio (UPB) recorded quarterly Net Income towards Common Stockholders of -$40.6 million in Q1 2026, up 4.47% quarter-over-quarter from -$42.5 million in Q4 2025, and down 48.74% on a YoY basis from -$79.1 million in Q1 2025.

Upstream Bio (UPB) Net Income towards Common Stockholders (2023 - 2026) Analysis & Trends

Upstream Bio's Net Income towards Common Stockholders history runs 4 years deep, the most recent figure standing at -$40.6 million for Q1 2026.

  • In Q1 2026, Net Income towards Common Stockholders fell 48.74% year-over-year to -$40.6 million; the TTM figure through Mar 2026 stood at -$156.7 million (down 74.82% YoY), while the FY2025 annual figure was -$143.4 million, down 87.76% from the prior year.
  • Net Income towards Common Stockholders was -$40.6 million for Q1 2026 at Upstream Bio, up from -$42.5 million in the prior quarter.
  • In the past five years, Net Income towards Common Stockholders ranged from a high of -$6.3 million in Q3 2023 to a low of -$42.5 million in Q4 2025.
  • Historically, Net Income towards Common Stockholders has averaged -$25.6 million across 4 years, with a median of -$21.8 million in 2024.
  • Biggest YoY gain for Net Income towards Common Stockholders was 45.42% in 2024; the steepest drop was 236.37% in 2024.
  • A 4-year view of Net Income towards Common Stockholders shows it stood at -$15.0 million in 2023, then sank by 45.42% to -$21.8 million in 2024, then sank by 94.86% to -$42.5 million in 2025, then grew by 4.47% to -$40.6 million in 2026.
  • The last three Net Income towards Common Stockholders figures came in at -$40.6 million (Q1 2026), -$42.5 million (Q4 2025), and -$33.7 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Income (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -26.94 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -13.56 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 2.50 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.63 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -14.46 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -1.50 Mn
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.03 Bn
9 Abivax 91.96 Bn 91.96 Bn - -56.48 Mn
10 Upstream Bio 339.03 Mn 339.03 Mn -3.94 Mn -40.56 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -40.56 Mn
Dec 31, 2025 -42.46 Mn
Sep 30, 2025 -33.75 Mn
Jun 30, 2025 -39.97 Mn
Mar 31, 2025 -27.27 Mn
Dec 31, 2024 -21.79 Mn
Sep 30, 2024 -21.03 Mn
Jun 30, 2024 -19.56 Mn
Mar 31, 2024 -14.01 Mn
Dec 31, 2023 -14.98 Mn
Sep 30, 2023 -6.25 Mn