Upstream Bio (UPB) Net Income towards Common Stockholders (2023 - 2026)

Upstream Bio's (UPB) quarterly Net Income towards Common Stockholders came in at -$61.8 million in Q1 2026, down 126.57% year-on-year from $232.5 million in Q1 2025, and down 45.52% quarter-over-quarter from -$42.5 million in Q4 2025.

Upstream Bio (UPB) Net Income towards Common Stockholders (2023 - 2026) Analysis & Trends

Upstream Bio's Net Income towards Common Stockholders history runs 4 years deep, the most recent figure standing at -$61.8 million for Q1 2026.

  • On a quarterly basis, Net Income towards Common Stockholders fell 126.57% year-over-year to -$61.8 million in Q1 2026; TTM through Mar 2026 was -$178.0 million, a 98.49% decrease from a year earlier, with the FY2025 full-year figure at -$143.4 million, down 87.76% from the prior year.
  • Net Income towards Common Stockholders retreated to -$61.8 million in Q1 2026 per UPB's latest filing, from -$42.5 million in the prior quarter.
  • Across five years, Net Income towards Common Stockholders topped out at -$6.3 million in Q3 2023 and bottomed at -$61.8 million in Q1 2026.
  • The 4-year median for Net Income towards Common Stockholders is -$21.8 million (2024), against an average of -$27.5 million.
  • Biggest YoY gain for Net Income towards Common Stockholders was 45.42% in 2024; the steepest drop was 236.37% in 2024.
  • Year by year, Net Income towards Common Stockholders stood at -$15.0 million in 2023, then tumbled by 45.42% to -$21.8 million in 2024, then tumbled by 94.86% to -$42.5 million in 2025, then tumbled by 45.52% to -$61.8 million in 2026.
  • Per Business Quant, the three latest UPB Net Income towards Common Stockholders figures stand at -$61.8 million (Q1 2026), -$42.5 million (Q4 2025), and -$33.7 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Income (Qtr)
1 Oculis Holding AG 66,621.14 Bn 66,620.85 Bn - -625.73
2 Nanobiotix 1,915.18 Bn 1,915.11 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -14.46 Mn
4 BeOne Medicines 471.27 Bn 466.48 Bn 1.35 Bn 227.36 Mn
5 Vertex Pharmaceuticals 121.81 Bn 114.57 Bn 2.59 Bn 1.03 Bn
6 Regeneron Pharmaceuticals 69.58 Bn 60.82 Bn 3.31 Bn 727.20 Mn
7 Belite Bio 62.72 Bn 62.72 Bn - -0.68
8 Argenx Se 55.51 Bn 50.33 Bn 1.41 Bn 472.00 Mn
9 Revolution Medicines 37.35 Bn 37.35 Bn - -453.82 Mn
10 Upstream Bio 347.18 Mn 347.18 Mn -3.94 Mn -61.79 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -61.79 Mn
Dec 31, 2025 -42.46 Mn
Sep 30, 2025 -33.75 Mn
Jun 30, 2025 -39.97 Mn
Mar 31, 2025 -27.27 Mn
Dec 31, 2024 -21.79 Mn
Sep 30, 2024 -21.03 Mn
Jun 30, 2024 -19.56 Mn
Mar 31, 2024 -14.01 Mn
Dec 31, 2023 -14.98 Mn
Sep 30, 2023 -6.25 Mn