Balance Sheet
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Amortizatization of IntangiblesCapital ExpendituresCash from Financing ActivitiesCash from Investing ActivitiesCash from OperationsChange in Account PayablesChange in Accured ExpensesChange in Acquisitions & DivestmentsChange in CashChange in ReceivablesDepreciation & Amortization (CF)Free Cash FlowGains from Investment SecuritiesNet Cash FlowNet IncomeNon-cash ItemsOther financing activitiesShare-based CompensationShares Issued
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Upstream Bio (UPB) Net Income (2023 - 2025)

Upstream Bio has reported Net Income over the past 3 years, most recently at -$42.5 million for Q4 2025.

  • Quarterly results put Net Income at -$42.5 million for Q4 2025, down 100.14% from a year ago — trailing twelve months through Dec 2025 was -$143.4 million (down 118.5% YoY), and the annual figure for FY2025 was -$143.4 million, down 118.5%.
  • Net Income for Q4 2025 was -$42.5 million at Upstream Bio, down from -$33.7 million in the prior quarter.
  • Over the last five years, Net Income for UPB hit a ceiling of -$7.9 million in Q3 2023 and a floor of -$42.5 million in Q4 2025.
  • Median Net Income over the past 3 years was -$18.6 million (2024), compared with a mean of -$23.0 million.
  • Biggest five-year swings in Net Income: plummeted 65.81% in 2024 and later crashed 172.22% in 2025.
  • Upstream Bio's Net Income stood at -$12.8 million in 2023, then plummeted by 65.81% to -$21.2 million in 2024, then tumbled by 100.14% to -$42.5 million in 2025.
  • The last three reported values for Net Income were -$42.5 million (Q4 2025), -$33.7 million (Q3 2025), and -$39.9 million (Q2 2025) per Business Quant data.