Upstream Bio (UPB) Net Income (2023 - 2026)

Upstream Bio's Net Income history runs 4 years deep, the most recent figure standing at -$61.8 million for Q1 2026.

• On a quarterly basis, Net Income fell 77.23% year-over-year to -$61.8 million in Q1 2026; TTM through Mar 2026 was -$484.0 million, a 146.9% decrease from a year earlier, with the FY2025 full-year figure at -$305.7 million, down 123.29% from the prior year.
• Net Income improved to -$61.8 million in Q1 2026 per UPB's latest filing, from -$204.8 million in the prior quarter.
• Across five years, Net Income topped out at -$7.9 million in Q3 2023 and bottomed at -$204.8 million in Q4 2025.
• The 4-year median for Net Income is -$52.5 million (2023), against an average of -$68.7 million.
• Biggest YoY gain for Net Income was 76.19% in 2024; the steepest drop was 549.96% in 2024.
• Year by year, Net Income stood at -$52.5 million in 2023, then sank by 76.19% to -$92.5 million in 2024, then tumbled by 121.38% to -$204.8 million in 2025, then surged by 69.83% to -$61.8 million in 2026.
• Per Business Quant, the three latest UPB Net Income figures stand at -$61.8 million (Q1 2026), -$204.8 million (Q4 2025), and -$133.3 million (Q3 2025).