Upstream Bio (UPB) Interest Expenses (2023 - 2026)

Upstream Bio's (UPB) quarterly Interest Expenses came in at $21.2 million in Q1 2026, up 179.53% year-on-year from $7.6 million in Q1 2025, and down 86.92% quarter-over-quarter from $162.3 million in Q4 2025.

Upstream Bio (UPB) Interest Expenses (2023 - 2026) Analysis & Trends

Upstream Bio's Interest Expenses history runs 4 years deep, the most recent figure standing at $21.2 million for Q1 2026.

  • On a quarterly basis, Interest Expenses rose 179.53% year-over-year to $21.2 million in Q1 2026; TTM through Mar 2026 was $21.2 million, a 179.53% increase from a year earlier, with the FY2025 full-year figure at $162.3 million, up 127.71% from the prior year.
  • Interest Expenses eased to $21.2 million in Q1 2026 per UPB's latest filing, from $162.3 million in the prior quarter.
  • Across five years, Interest Expenses topped out at $162.3 million in Q4 2025 and bottomed at $7.6 million in Q1 2025.
  • The 4-year median for Interest Expenses is $39.7 million (2023), against an average of $59.5 million.
  • Across the five-year window, Interest Expenses surged 79.53% in 2024 and jumped 183.66% in 2025, its largest moves.
  • Year by year, Interest Expenses stood at $39.7 million in 2023, then jumped by 79.53% to $71.3 million in 2024, then soared by 127.71% to $162.3 million in 2025, then sank by 86.92% to $21.2 million in 2026.
  • Per Business Quant, the three latest UPB Interest Expenses figures stand at $21.2 million (Q1 2026), $162.3 million (Q4 2025), and $99.5 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Int Expense (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -42,141.15
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - 100,000.00
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 32.89 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 420.30 Mn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 28.30 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -
9 Revolution Medicines 37.37 Bn 37.37 Bn - 1.17 Bn
10 Upstream Bio 343.65 Mn 343.65 Mn -3.94 Mn 21.23 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 21.23 Mn
Mar 31, 2026 21.23 Mn
Dec 31, 2025 162.28 Mn
Dec 31, 2025 162.28 Mn
Sep 30, 2025 99.54 Mn
Sep 30, 2025 99.54 Mn
Jun 30, 2025 39.69 Mn
Jun 30, 2025 39.69 Mn
Mar 31, 2025 7.59 Mn
Mar 31, 2025 7.59 Mn
Dec 31, 2024 71.27 Mn
Dec 31, 2024 71.27 Mn
Sep 30, 2024 35.09 Mn
Sep 30, 2024 35.09 Mn
Dec 31, 2023 39.70 Mn
Dec 31, 2023 39.70 Mn