Upstream Bio (UPB) Gross Profit (2024 - 2026)
Upstream Bio's (UPB) quarterly Gross Profit came in at -$3.9 million in Q1 2026, down 152.02% year-on-year from $7.6 million in Q1 2025, and up 48.67% quarter-over-quarter from -$7.7 million in Q4 2025.
Upstream Bio (UPB) Gross Profit (2024 - 2026) Analysis & Trends
Upstream Bio's Gross Profit history runs 3 years deep, the most recent figure standing at -$3.9 million for Q1 2026.
- On a quarterly basis, Gross Profit fell 152.02% year-over-year to -$3.9 million in Q1 2026; TTM through Mar 2026 was -$22.5 million, a 264.17% decrease from a year earlier, with the FY2025 full-year figure at -$20.2 million, down 378.84% from the prior year.
- Gross Profit grew to -$3.9 million in Q1 2026 per UPB's latest filing, from -$7.7 million in the prior quarter.
- Across five years, Gross Profit topped out at $289000.0 in Q1 2024 and bottomed at -$9.1 million in Q2 2025.
- The 3-year median for Gross Profit is -$1.9 million (2025), against an average of -$3.2 million.
- Biggest YoY gain for Gross Profit was 18.26% in 2025; the steepest drop was 900.33% in 2025.
- Year by year, Gross Profit stood at -$2.1 million in 2024, then slumped by 257.43% to -$7.7 million in 2025, then surged by 48.67% to -$3.9 million in 2026.
- Per Business Quant, the three latest UPB Gross Profit figures stand at -$3.9 million (Q1 2026), -$7.7 million (Q4 2025), and -$1.9 million (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - |
| 10 | Upstream Bio | 347.73 Mn | 347.73 Mn | -3.94 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -3.94 Mn |
| Mar 31, 2026 | -3.94 Mn |
| Dec 31, 2025 | -7.67 Mn |
| Dec 31, 2025 | -7.67 Mn |
| Sep 30, 2025 | -1.86 Mn |
| Sep 30, 2025 | -1.86 Mn |
| Jun 30, 2025 | -9.06 Mn |
| Jun 30, 2025 | -9.06 Mn |
| Mar 31, 2025 | -1.56 Mn |
| Mar 31, 2025 | -1.56 Mn |
| Dec 31, 2024 | -2.15 Mn |
| Dec 31, 2024 | -2.15 Mn |
| Sep 30, 2024 | -1.57 Mn |
| Sep 30, 2024 | -1.57 Mn |
| Jun 30, 2024 | -906,000.00 |
| Jun 30, 2024 | -906,000.00 |
| Mar 31, 2024 | 289,000.00 |
| Mar 31, 2024 | 289,000.00 |