Upstream Bio (UPB) Gross Profit (2024 - 2026)

Upstream Bio's Gross Profit history runs 3 years deep, the most recent figure standing at -$3.9 million for Q1 2026.

• In Q1 2026, Gross Profit fell 152.02% year-over-year to -$3.9 million; the TTM figure through Mar 2026 stood at -$22.5 million (down 264.17% YoY), while the FY2025 annual figure was -$20.2 million, down 378.84% from the prior year.
• Gross Profit was -$3.9 million for Q1 2026 at Upstream Bio, up from -$7.7 million in the prior quarter.
• In the past five years, Gross Profit ranged from a high of $289000.0 in Q1 2024 to a low of -$9.1 million in Q2 2025.
• Historically, Gross Profit has averaged -$3.2 million across 3 years, with a median of -$1.9 million in 2025.
• Biggest YoY gain for Gross Profit was 18.26% in 2025; the steepest drop was 900.33% in 2025.
• A 3-year view of Gross Profit shows it stood at -$2.1 million in 2024, then plunged by 257.43% to -$7.7 million in 2025, then surged by 48.67% to -$3.9 million in 2026.
• The last three Gross Profit figures came in at -$3.9 million (Q1 2026), -$7.7 million (Q4 2025), and -$1.9 million (Q3 2025), per Business Quant data.