Upstream Bio (UPB) Gross Profit (2024 - 2026)

Upstream Bio's Gross Profit history runs 3 years deep, the most recent figure standing at -$3.9 million for Q1 2026.

• In Q1 2026, Gross Profit fell 152.02% year-over-year to -$3.9 million; the TTM figure through Mar 2026 stood at -$22.5 million (down 264.17% YoY), while the FY2025 annual figure was -$20.2 million, down 378.84% from the prior year.
• Gross Profit for Q1 2026 stood at -$3.9 million, up from -$7.7 million in the prior quarter.
• The five-year high for Gross Profit was $289000.0 in Q1 2024, with the low at -$9.1 million in Q2 2025.
• The 3-year median for Gross Profit is -$1.9 million (2025), against an average of -$3.2 million.
• Peak annual rise in Gross Profit reached 18.26% in 2025, while the deepest fall reached 900.33% in 2025.
• Upstream Bio's Gross Profit stood at -$2.1 million in 2024, then tumbled by 257.43% to -$7.7 million in 2025, then jumped by 48.67% to -$3.9 million in 2026.
• Business Quant data shows UPB's Gross Profit at -$3.9 million in Q1 2026, -$7.7 million in Q4 2025, and -$1.9 million in Q3 2025.