Upstream Bio (UPB) Gross Profit (2024 - 2026)
Upstream Bio's quarterly Gross Profit came in at -$3.9 million in Q1 2026, down 152.02% year-on-year from $7.6 million in Q1 2025, and up 48.67% quarter-over-quarter from -$7.7 million in Q4 2025.
Upstream Bio has reported Gross Profit for 3 years, with the latest figure at -$3.9 million in Q1 2026.
- For the quarter ending Q1 2026, Gross Profit fell 152.02% year-over-year to -$3.9 million; the trailing twelve-month figure through Mar 2026 stood at -$22.5 million (down 264.17% YoY), and the FY2025 full-year result was -$20.2 million, down 378.84% from the prior year.
- Gross Profit for Q1 2026 stood at -$3.9 million, up from -$7.7 million in the prior quarter.
- The five-year high for Gross Profit was $289000.0 in Q1 2024, with the low at -$9.1 million in Q2 2025.
- Average Gross Profit over 3 years is -$3.2 million, with a median of -$1.9 million recorded in 2025.
- Peak annual rise in Gross Profit reached 18.26% in 2025, while the deepest fall reached 900.33% in 2025.
- Tracing UPB's Gross Profit over 3 years: stood at -$2.1 million in 2024, then tumbled by 257.43% to -$7.7 million in 2025, then soared by 48.67% to -$3.9 million in 2026.
- The last three Gross Profit figures came in at -$3.9 million (Q1 2026), -$7.7 million (Q4 2025), and -$1.9 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -3.94 Mn |
| Mar 31, 2026 | -3.94 Mn |
| Dec 31, 2025 | -7.67 Mn |
| Dec 31, 2025 | -7.67 Mn |
| Sep 30, 2025 | -1.86 Mn |
| Sep 30, 2025 | -1.86 Mn |
| Jun 30, 2025 | -9.06 Mn |
| Jun 30, 2025 | -9.06 Mn |
| Mar 31, 2025 | -1.56 Mn |
| Mar 31, 2025 | -1.56 Mn |
| Dec 31, 2024 | -2.15 Mn |
| Dec 31, 2024 | -2.15 Mn |
| Sep 30, 2024 | -1.57 Mn |
| Sep 30, 2024 | -1.57 Mn |
| Jun 30, 2024 | -906,000.00 |
| Jun 30, 2024 | -906,000.00 |
| Mar 31, 2024 | 289,000.00 |
| Mar 31, 2024 | 289,000.00 |