Upstream Bio (UPB) Common Equity (2023 - 2026)

Upstream Bio's (UPB) quarterly Common Equity came in at $304.0 million in Q1 2026, down 31.78% year-on-year from $445.6 million in Q1 2025, and down 10.53% quarter-over-quarter from $339.8 million in Q4 2025.

Upstream Bio (UPB) Common Equity (2023 - 2026) Analysis & Trends

Upstream Bio's Common Equity history runs 4 years deep, the most recent figure standing at $304.0 million for Q1 2026.

  • On a quarterly basis, Common Equity fell 31.78% year-over-year to $304.0 million in Q1 2026; TTM through Mar 2026 was $304.0 million, a 31.78% decrease from a year earlier, with the FY2025 full-year figure at $339.8 million, down 27.69% from the prior year.
  • Common Equity slipped to $304.0 million in Q1 2026 per UPB's latest filing, from $339.8 million in the prior quarter.
  • Across five years, Common Equity topped out at $469.9 million in Q4 2024 and bottomed at -$160.3 million in Q3 2024.
  • The 4-year median for Common Equity is $304.0 million (2026), against an average of $151.9 million.
  • Biggest YoY gain for Common Equity was 481.6% in 2024; the steepest drop was 42.87% in 2024.
  • Year by year, Common Equity stood at -$123.1 million in 2023, then jumped by 481.6% to $469.9 million in 2024, then dropped by 27.69% to $339.8 million in 2025, then dropped by 10.53% to $304.0 million in 2026.
  • Per Business Quant, the three latest UPB Common Equity figures stand at $304.0 million (Q1 2026), $339.8 million (Q4 2025), and $378.6 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Common Equity (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - 251.12 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -98.34 Mn
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 4.76 Bn
4 NuCana 279.75 Bn 279.75 Bn - 32.36 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 19.36 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 31.42 Bn
7 Belite Bio 62.51 Bn 62.51 Bn - 795.79 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - 1.50 Bn
10 Upstream Bio 347.73 Mn 347.73 Mn -3.94 Mn 304.00 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 304.00 Mn
Dec 31, 2025 339.77 Mn
Sep 30, 2025 378.58 Mn
Jun 30, 2025 408.74 Mn
Mar 31, 2025 445.61 Mn
Dec 31, 2024 469.85 Mn
Sep 30, 2024 -160.31 Mn
Jun 30, 2024 -146.61 Mn
Mar 31, 2024 -133.41 Mn
Dec 31, 2023 -123.13 Mn
Sep 30, 2023 -112.20 Mn