Upstream Bio (UPB) EBT (2023 - 2026)
Upstream Bio's (UPB) quarterly EBT came in at -$61.8 million in Q1 2026, down 77.23% year-on-year from -$271.3 million in Q1 2025, and up 69.83% quarter-over-quarter from -$204.8 million in Q4 2025.
Upstream Bio (UPB) EBT (2023 - 2026) Analysis & Trends
Upstream Bio's EBT history runs 4 years deep, the most recent figure standing at -$61.8 million for Q1 2026.
- On a quarterly basis, EBT fell 77.23% year-over-year to -$61.8 million in Q1 2026; TTM through Mar 2026 was -$484.0 million, a 146.9% decrease from a year earlier, with the FY2025 full-year figure at -$305.7 million, down 123.29% from the prior year.
- EBT improved to -$61.8 million in Q1 2026 per UPB's latest filing, from -$204.8 million in the prior quarter.
- Across five years, EBT topped out at -$7.9 million in Q3 2023 and bottomed at -$204.8 million in Q4 2025.
- The 4-year median for EBT is -$52.5 million (2023), against an average of -$68.7 million.
- Biggest YoY gain for EBT was 76.19% in 2024; the steepest drop was 549.96% in 2024.
- Year by year, EBT stood at -$52.5 million in 2023, then sank by 76.19% to -$92.5 million in 2024, then tumbled by 121.38% to -$204.8 million in 2025, then surged by 69.83% to -$61.8 million in 2026.
- Per Business Quant, the three latest UPB EBT figures stand at -$61.8 million (Q1 2026), -$204.8 million (Q4 2025), and -$133.3 million (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -36.97 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | -15.31 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 259.22 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.25 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 831.20 Mn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | -26.94 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | 438.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | -453.82 Mn |
| 10 | Upstream Bio | 343.65 Mn | 343.65 Mn | -3.94 Mn | -61.79 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -61.79 Mn |
| Dec 31, 2025 | -204.79 Mn |
| Sep 30, 2025 | -133.27 Mn |
| Jun 30, 2025 | -84.15 Mn |
| Mar 31, 2025 | -34.86 Mn |
| Dec 31, 2024 | -92.51 Mn |
| Sep 30, 2024 | -51.08 Mn |
| Jun 30, 2024 | -17.57 Mn |
| Mar 31, 2024 | -15.06 Mn |
| Dec 31, 2023 | -52.51 Mn |
| Sep 30, 2023 | -7.86 Mn |