Upstream Bio (UPB) EBITDA: 2023-2025

Historic EBITDA for Upstream Bio (UPB) over the last 2 years, with Sep 2025 value amounting to -$37.8 million.

  • Upstream Bio's EBITDA fell 100.25% to -$37.8 million in Q3 2025 from the same period last year, while for Sep 2025 it was -$140.5 million, marking a year-over-year decrease of 113.62%. This contributed to the annual value of -$77.8 million for FY2024, which is 93.86% down from last year.
  • According to the latest figures from Q3 2025, Upstream Bio's EBITDA is -$37.8 million, which was up 14.69% from -$44.3 million recorded in Q2 2025.
  • In the past 5 years, Upstream Bio's EBITDA ranged from a high of -$9.4 million in Q3 2023 and a low of -$44.3 million during Q2 2025.
  • Moreover, its 3-year median value for EBITDA was -$18.9 million (2024), whereas its average is -$24.0 million.
  • Data for Upstream Bio's EBITDA shows a maximum YoY plummeted of 152.83% (in 2025) over the last 5 years.
  • Upstream Bio's EBITDA (Quarterly) stood at -$14.3 million in 2023, then plummeted by 83.66% to -$26.3 million in 2024, then tumbled by 100.25% to -$37.8 million in 2025.
  • Its last three reported values are -$37.8 million in Q3 2025, -$44.3 million for Q2 2025, and -$32.0 million during Q1 2025.