Upstream Bio (UPB) EBITDA: 2023-2025

Historic EBITDA for Upstream Bio (UPB) over the last 2 years, with Sep 2025 value amounting to -$37.8 million.

  • Upstream Bio's EBITDA fell 100.25% to -$37.8 million in Q3 2025 from the same period last year, while for Sep 2025 it was -$140.5 million, marking a year-over-year decrease of 113.62%. This contributed to the annual value of -$77.8 million for FY2024, which is 93.86% down from last year.
  • Per Upstream Bio's latest filing, its EBITDA stood at -$37.8 million for Q3 2025, which was up 14.69% from -$44.3 million recorded in Q2 2025.
  • In the past 5 years, Upstream Bio's EBITDA registered a high of -$9.4 million during Q3 2023, and its lowest value of -$44.3 million during Q2 2025.
  • Over the past 3 years, Upstream Bio's median EBITDA value was -$18.9 million (recorded in 2024), while the average stood at -$24.0 million.
  • Data for Upstream Bio's EBITDA shows a maximum YoY plummeted of 152.83% (in 2025) over the last 5 years.
  • Over the past 3 years, Upstream Bio's EBITDA (Quarterly) stood at -$14.3 million in 2023, then slumped by 83.66% to -$26.3 million in 2024, then slumped by 100.25% to -$37.8 million in 2025.
  • Its EBITDA was -$37.8 million in Q3 2025, compared to -$44.3 million in Q2 2025 and -$32.0 million in Q1 2025.