Upstream Bio (UPB) EBITDA (2023 - 2026)
Upstream Bio's quarterly EBITDA came in at -$43.6 million in Q1 2026, down 36.24% year-on-year from -$68.4 million in Q1 2025, and up 5.53% quarter-over-quarter from -$46.2 million in Q4 2025.
Upstream Bio has reported EBITDA for 4 years, with the latest figure at -$43.6 million in Q1 2026.
- For the quarter ending Q1 2026, EBITDA fell 36.24% year-over-year to -$43.6 million; the trailing twelve-month figure through Mar 2026 stood at -$172.0 million (down 81.46% YoY), and the FY2025 full-year result was -$160.4 million, down 106.21% from the prior year.
- EBITDA for Q1 2026 stood at -$43.6 million, up from -$46.2 million in the prior quarter.
- The five-year high for EBITDA was -$9.4 million in Q3 2023, with the low at -$46.2 million in Q4 2025.
- Average EBITDA over 4 years is -$27.8 million, with a median of -$26.3 million recorded in 2024.
- Year-over-year, EBITDA tumbled 152.83% in 2025 and plunged 36.24% in 2026.
- Tracing UPB's EBITDA over 4 years: stood at -$14.3 million in 2023, then slumped by 83.66% to -$26.3 million in 2024, then sank by 75.42% to -$46.2 million in 2025, then advanced by 5.53% to -$43.6 million in 2026.
- The last three EBITDA figures came in at -$43.6 million (Q1 2026), -$46.2 million (Q4 2025), and -$37.8 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | -13.63 Mn |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | -19.70 Mn |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | -14.44 Mn |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 1.14 Bn |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | -3.82 Mn |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 661.60 Mn |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 201.19 Mn |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn | -43.62 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -43.62 Mn |
| Dec 31, 2025 | -46.17 Mn |
| Sep 30, 2025 | -37.83 Mn |
| Jun 30, 2025 | -44.35 Mn |
| Mar 31, 2025 | -32.01 Mn |
| Dec 31, 2024 | -26.32 Mn |
| Sep 30, 2024 | -18.89 Mn |
| Jun 30, 2024 | -17.54 Mn |
| Mar 31, 2024 | -15.01 Mn |
| Dec 31, 2023 | -14.33 Mn |
| Sep 30, 2023 | -9.39 Mn |