Upstream Bio (UPB) EBITDA (2023 - 2026)
Upstream Bio (UPB) recorded EBITDA of -$42.32 million in Q2 2026, compared with -$44.31 million a year earlier.
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Analysis
Upstream Bio (UPB) EBITDA (2023 - 2026) Analysis & Trends
On a TTM basis, Upstream Bio's EBITDA came in at -$169.77 million as of Jun 30, 2026; for FY2025, it came in at -$160.16 million.
- Across earlier years, EBITDA came in at -$77.68 million in FY2024 and -$40.05 million in FY2023.
- Quarterly EBITDA has ranged from -$46.1 million in Q4 2025 to -$14.32 million in Q4 2023 over the past five years.
- Per Business Quant, the preceding three quarters came in at -$43.57 million (Q1 2026), -$46.1 million (Q4 2025) and -$37.79 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,132.04 Bn | 1,100.62 Bn | 19.71 Bn | 12.29 Bn |
| 2 | Johnson & Johnson | 614.86 Bn | 533.39 Bn | 17.26 Bn | 9.10 Bn |
| 3 | AbbVie | 503.32 Bn | 476.44 Bn | 12.70 Bn | 8.33 Bn |
| 4 | Merck | 367.14 Bn | 321.52 Bn | 12.21 Bn | 999.00 Mn |
| 5 | Novartis Ag | 297.85 Bn | 261.84 Bn | 11.24 Bn | - |
| 6 | Astrazeneca | 261.69 Bn | 235.37 Bn | 12.86 Bn | 5.09 Bn |
| 7 | Amgen | 236.43 Bn | 191.82 Bn | 7.24 Bn | 4.63 Bn |
| 8 | Gilead Sciences | 190.71 Bn | 164.90 Bn | 6.22 Bn | -9.70 Bn |
| 9 | Pfizer | 170.03 Bn | 116.68 Bn | 10.94 Bn | 5.89 Bn |
| 10 | Upstream Bio | 157.16 Mn | -1.11 Bn | -3.29 Mn | -42.32 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -42.32 Mn |
| Mar 31, 2026 | -43.57 Mn |
| Dec 31, 2025 | -46.10 Mn |
| Sep 30, 2025 | -37.79 Mn |
| Jun 30, 2025 | -44.31 Mn |
| Mar 31, 2025 | -31.97 Mn |
| Dec 31, 2024 | -26.27 Mn |
| Sep 30, 2024 | -18.88 Mn |
| Jun 30, 2024 | -17.53 Mn |
| Mar 31, 2024 | -15.00 Mn |
| Dec 31, 2023 | -14.32 Mn |
API Access
Upstream Bio EBITDA API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();