Upstream Bio (UPB) EBITDA (2023 - 2026)
Upstream Bio (UPB) recorded EBITDA of -$42.32 million in Q2 2026, compared with -$44.31 million a year earlier.
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Analysis
Upstream Bio (UPB) EBITDA (2023 - 2026) Analysis & Trends
On a TTM basis, Upstream Bio's EBITDA came in at -$169.77 million as of Jun 30, 2026; for FY2025, it came in at -$160.16 million.
- Across earlier years, EBITDA came in at -$77.68 million in FY2024 and -$40.05 million in FY2023.
- Quarterly EBITDA has ranged from -$46.1 million in Q4 2025 to -$14.32 million in Q4 2023 over the past five years.
- Per Business Quant, the preceding three quarters came in at -$43.57 million (Q1 2026), -$46.1 million (Q4 2025) and -$37.79 million (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 8.95 Bn |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 8.30 Bn |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | 8.16 Bn |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 7.34 Bn |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 5.99 Bn |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 4.83 Bn |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | 4.20 Bn |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 7.05 Bn |
| 10 | Upstream Bio | 185.26 Mn | -919.50 Mn | - | -43.75 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -43.75 Mn |
| Jun 30, 2026 | -42.36 Mn |
| Mar 31, 2026 | -44.32 Mn |
| Dec 31, 2025 | -44.73 Mn |
| Sep 30, 2025 | -37.94 Mn |
| Jun 30, 2025 | -45.29 Mn |
| Mar 31, 2025 | -33.71 Mn |
| Dec 31, 2024 | -25.59 Mn |
| Sep 30, 2024 | -19.45 Mn |
| Jun 30, 2024 | -18.67 Mn |
| Mar 31, 2024 | -15.62 Mn |
| Dec 31, 2023 | -14.56 Mn |
API Access
Upstream Bio EBITDA API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=ebitda&ticker=UPB&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "ebitda", "ticker": "UPB", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=ebitda&ticker=UPB&period=max&api_key=YOUR_API_KEY");
const data = await res.json();