Upstream Bio (UPB) EBIT (2023 - 2026)
Upstream Bio (UPB) recorded quarterly EBIT of -$43.6 million in Q1 2026, up 5.53% quarter-over-quarter from -$46.2 million in Q4 2025, and down 36.24% on a YoY basis from -$68.4 million in Q1 2025.
Upstream Bio (UPB) EBIT (2023 - 2026) Analysis & Trends
Upstream Bio's EBIT history runs 4 years deep, the most recent figure standing at -$43.6 million for Q1 2026.
- In Q1 2026, EBIT fell 36.24% year-over-year to -$43.6 million; the TTM figure through Mar 2026 stood at -$172.0 million (down 81.46% YoY), while the FY2025 annual figure was -$160.4 million, down 106.21% from the prior year.
- EBIT was -$43.6 million for Q1 2026 at Upstream Bio, up from -$46.2 million in the prior quarter.
- In the past five years, EBIT ranged from a high of -$9.4 million in Q3 2023 to a low of -$46.2 million in Q4 2025.
- Historically, EBIT has averaged -$27.8 million across 4 years, with a median of -$26.3 million in 2024.
- The sharpest annual moves came in 2025 and 2026: EBIT tumbled 152.83% in 2025, then plunged 36.24% in 2026.
- A 4-year view of EBIT shows it stood at -$14.3 million in 2023, then tumbled by 83.66% to -$26.3 million in 2024, then slumped by 75.42% to -$46.2 million in 2025, then gained by 5.53% to -$43.6 million in 2026.
- The last three EBIT figures came in at -$43.6 million (Q1 2026), -$46.2 million (Q4 2025), and -$37.8 million (Q3 2025), per Business Quant data.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBIT (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | -32.68 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -2.97 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -15.76 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | -1.51 Mn |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -65.83 Mn |
| 10 | Upstream Bio | 339.03 Mn | 339.03 Mn | -3.94 Mn | -43.62 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -43.62 Mn |
| Dec 31, 2025 | -46.17 Mn |
| Sep 30, 2025 | -37.83 Mn |
| Jun 30, 2025 | -44.35 Mn |
| Mar 31, 2025 | -32.01 Mn |
| Dec 31, 2024 | -26.32 Mn |
| Sep 30, 2024 | -18.89 Mn |
| Jun 30, 2024 | -17.54 Mn |
| Mar 31, 2024 | -15.01 Mn |
| Dec 31, 2023 | -14.33 Mn |
| Sep 30, 2023 | -9.39 Mn |