SOPHiA GENETICS (SOPH) Gross Margin (2020 - 2025)
SOPHiA GENETICS's (SOPH) quarterly Gross Margin came in at 67.68% in Q4 2025, down 56.0% year-on-year from 153.83% in Q4 2024, and up 2.06% quarter-over-quarter from 66.32% in Q3 2025.
SOPHiA GENETICS (SOPH) Gross Margin (2020 - 2025) Analysis & Trends
SOPHiA GENETICS has disclosed Gross Margin across 6 years of filings, most recently posting 67.68% for Q4 2025.
- Gross Margin for Q4 2025 came in at 67.68%, down 56.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 67.4% (down 2.0% YoY), and the FY2025 annual result was 67.4%, down 2.0% from the prior year.
- Gross Margin came in at 67.68% for Q4 2025 at SOPHiA GENETICS, up from 66.32% in the prior quarter.
- In the past five years, Gross Margin ranged from a high of 71.96% in Q4 2022 to a low of 61.21% in Q2 2021.
- The 5-year median for Gross Margin is 66.85% (2023), against an average of 66.36%.
- Peak annual rise in Gross Margin reached 6317 bps in 2021, while the deepest fall reached 583 bps in 2021.
- SOPHiA GENETICS's Gross Margin stood at 62.45% in 2021, then rose by 15 bps to 71.96% in 2022, then retreated by 3 bps to 69.79% in 2023, then slipped by 2 bps to 68.25% in 2024, then fell by 1 bps to 67.68% in 2025.
- The last three Gross Margin figures came in at 67.68% (Q4 2025), 66.32% (Q3 2025), and 66.97% (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 24.83 Bn | 17.52 Bn | 662.02 Mn | 74.98% |
| 2 | BrightSpring Health Services | 13.57 Bn | 12.69 Bn | 482.22 Mn | 13.34% |
| 3 | Healthequity | 7.20 Bn | 6.93 Bn | 256.31 Mn | 72.27% |
| 4 | Hinge Health | 5.42 Bn | 5.11 Bn | 154.23 Mn | 84.60% |
| 5 | 10x Genomics | 4.46 Bn | 3.92 Bn | 106.18 Mn | 70.39% |
| 6 | Doximity | 3.81 Bn | 3.06 Bn | 125.97 Mn | 86.65% |
| 7 | Waystar Holding | 3.52 Bn | 3.36 Bn | 268.04 Mn | 85.40% |
| 8 | Privia Health | 2.94 Bn | 2.57 Bn | 595.71 Mn | 98.65% |
| 9 | Omnicell | 1.76 Bn | 1.59 Bn | 140.36 Mn | 45.30% |
| 10 | SOPHiA GENETICS | 26.19 Mn | -44.10 Mn | 14.69 Mn | 67.68% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 67.68% |
| Sep 30, 2025 | 66.32% |
| Jun 30, 2025 | 66.97% |
| Mar 31, 2025 | 68.67% |
| Dec 31, 2024 | 68.25% |
| Sep 30, 2024 | 67.20% |
| Jun 30, 2024 | 68.17% |
| Mar 31, 2024 | 65.94% |
| Dec 31, 2023 | 69.79% |
| Sep 30, 2023 | 69.15% |
| Jun 30, 2023 | 66.74% |
| Mar 31, 2023 | 69.41% |
| Dec 31, 2022 | 71.96% |
| Sep 30, 2022 | 62.61% |
| Jun 30, 2022 | 65.31% |
| Mar 31, 2022 | 63.60% |
| Dec 31, 2021 | 62.45% |
| Sep 30, 2021 | 63.17% |
| Jun 30, 2021 | 61.21% |
| Mar 31, 2021 | 62.58% |