SOPHiA GENETICS (SOPH) Gross Margin (2020 - 2025)
SOPHiA GENETICS recorded quarterly Gross Margin of 67.68% in Q4 2025, up 2.06% quarter-over-quarter from 66.32% in Q3 2025, and down 56.0% year-over-year from 153.83% in Q4 2024.
SOPHiA GENETICS's Gross Margin history runs 6 years deep, the most recent figure standing at 67.68% for Q4 2025.
- In Q4 2025, Gross Margin fell 56.0% year-over-year to 67.68%; the TTM figure through Dec 2025 stood at 67.4% (down 2.0% YoY), while the FY2025 annual figure was 67.4%, down 2.0% from the prior year.
- Gross Margin came in at 67.68% for Q4 2025 at SOPHiA GENETICS, up from 66.32% in the prior quarter.
- In the past five years, Gross Margin ranged from a high of 61210453.92% in Q2 2021 to a low of 62.45% in Q4 2021.
- A 5-year average of 3060585.99% and a median of 67.08% in 2025 frame the typical range for Gross Margin.
- Across the five-year window, Gross Margin surged 2000000000 bps in 2021 and plunged 2000000000 bps in 2022, its largest moves.
- SOPHiA GENETICS's Gross Margin stood at 62.45% in 2021, then gained by 15 bps to 71.96% in 2022, then decreased by 3 bps to 69.79% in 2023, then dropped by 2 bps to 68.25% in 2024, then retreated by 1 bps to 67.68% in 2025.
- According to Business Quant data, Gross Margin over the past three periods registered 67.68%, 66.32%, and 66.97% for Q4 2025, Q3 2025, and Q2 2025 respectively.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 30.85 Bn | 24.28 Bn | 622.47 Mn | 74.46% |
| 2 | BrightSpring Health Services | 12.29 Bn | 11.41 Bn | 482.22 Mn | 13.34% |
| 3 | Healthequity | 7.80 Bn | 7.48 Bn | 256.31 Mn | 72.27% |
| 4 | Hinge Health | 4.82 Bn | 4.51 Bn | 154.23 Mn | 84.60% |
| 5 | Doximity | 4.21 Bn | 3.46 Bn | 125.97 Mn | 86.65% |
| 6 | Waystar Holding | 4.18 Bn | 4.03 Bn | 268.04 Mn | 85.40% |
| 7 | 10x Genomics | 3.78 Bn | 3.24 Bn | 106.18 Mn | 70.39% |
| 8 | Privia Health | 2.65 Bn | 2.28 Bn | 595.71 Mn | 98.65% |
| 9 | Omnicell | 1.95 Bn | 1.78 Bn | 140.36 Mn | 45.30% |
| 10 | SOPHiA GENETICS | 24.12 Mn | -46.17 Mn | 14.69 Mn | 67.68% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 67.68% |
| Sep 30, 2025 | 66.32% |
| Jun 30, 2025 | 66.97% |
| Mar 31, 2025 | 68.67% |
| Dec 31, 2024 | 68.25% |
| Sep 30, 2024 | 67.20% |
| Jun 30, 2024 | 68.17% |
| Mar 31, 2024 | 65.94% |
| Dec 31, 2023 | 69.79% |
| Sep 30, 2023 | 69.15% |
| Jun 30, 2023 | 66.74% |
| Mar 31, 2023 | 69.41% |
| Dec 31, 2022 | 71.96% |
| Sep 30, 2022 | 62.61% |
| Jun 30, 2022 | 65.31% |
| Mar 31, 2022 | 63.60% |
| Dec 31, 2021 | 62.45% |
| Sep 30, 2021 | 63.17% |
| Jun 30, 2021 | 61.21% |
| Mar 31, 2021 | 62.58% |
| Dec 31, 2020 | 62.41% |
| Sep 30, 2020 | 59.53% |
| Jun 30, 2020 | 67.04% |