SOPHiA GENETICS (SOPH) Gross Margin (2020 - 2025)
SOPHiA GENETICS (SOPH) posted Gross Margin of 67.68% for Q4 2025, up 2.06% sequentially from 66.32% in Q3 2025, and down 56.0% YoY from 153.83% in Q4 2024.
SOPHiA GENETICS (SOPH) Gross Margin (2020 - 2025) Analysis & Trends
SOPHiA GENETICS has reported Gross Margin for 6 years, with the latest figure at 67.68% in Q4 2025.
- Quarterly Gross Margin fell 56.0% year-over-year to 67.68% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 67.4% (down 2.0% YoY) and the FY2025 annual result came in at 67.4%, down 2.0% from the prior year.
- Gross Margin rose to 67.68% in Q4 2025 per SOPH's latest filing, from 66.32% in the prior quarter.
- Over five years, Gross Margin peaked at 61210453.92% in Q2 2021 and troughed at 62.45% in Q4 2021.
- A 5-year average of 3060585.99% and a median of 67.08% in 2025 frame the typical range for Gross Margin.
- The sharpest annual moves came in 2021 and 2022: Gross Margin soared 2000000000 bps in 2021, then sank 2000000000 bps in 2022.
- Over 5 years, Gross Margin stood at 62.45% in 2021, then advanced by 15 bps to 71.96% in 2022, then slipped by 3 bps to 69.79% in 2023, then declined by 2 bps to 68.25% in 2024, then decreased by 1 bps to 67.68% in 2025.
- According to Business Quant data, Gross Margin over the past three periods registered 67.68%, 66.32%, and 66.97% for Q4 2025, Q3 2025, and Q2 2025 respectively.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 39.72 Bn | 32.40 Bn | 662.02 Mn | 74.98% |
| 2 | BrightSpring Health Services | 12.19 Bn | 11.64 Bn | 492.75 Mn | 12.72% |
| 3 | Healthequity | 8.79 Bn | 8.52 Bn | 256.31 Mn | 72.27% |
| 4 | 10x Genomics | 7.31 Bn | 6.76 Bn | 112.50 Mn | 74.48% |
| 5 | Hinge Health | 7.10 Bn | 6.71 Bn | 183.95 Mn | 86.44% |
| 6 | MiniMed | 5.66 Bn | 5.36 Bn | 480.00 Mn | 57.35% |
| 7 | Waystar Holding | 4.76 Bn | 4.56 Bn | 221.99 Mn | 69.44% |
| 8 | Doximity | 4.46 Bn | 3.77 Bn | 132.93 Mn | 84.87% |
| 9 | Heartflow | 3.66 Bn | 3.28 Bn | 53.19 Mn | 83.00% |
| 10 | SOPHiA GENETICS | 553.79 Mn | 446.12 Mn | - | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 67.68% |
| Sep 30, 2025 | 66.32% |
| Jun 30, 2025 | 66.97% |
| Mar 31, 2025 | 68.67% |
| Dec 31, 2024 | 68.25% |
| Sep 30, 2024 | 67.20% |
| Jun 30, 2024 | 68.17% |
| Mar 31, 2024 | 65.94% |
| Dec 31, 2023 | 69.79% |
| Sep 30, 2023 | 69.15% |
| Jun 30, 2023 | 66.74% |
| Mar 31, 2023 | 69.41% |
| Dec 31, 2022 | 71.96% |
| Sep 30, 2022 | 62.61% |
| Jun 30, 2022 | 65.31% |
| Mar 31, 2022 | 63.60% |
| Dec 31, 2021 | 62.45% |
| Sep 30, 2021 | 63.17% |
| Jun 30, 2021 | 61,210,453.92% |
| Mar 31, 2021 | 62.58% |