SOPHiA GENETICS (SOPH) Gross Margin (2020 - 2025)
SOPHiA GENETICS (SOPH) reported Gross Margin of 67.68% for Q4 2025, down 56.0% on a YoY basis from 153.83% in Q4 2024, and up 2.06% sequentially from 66.32% in Q3 2025.
SOPHiA GENETICS (SOPH) Gross Margin (2020 - 2025) Analysis & Trends
SOPHiA GENETICS (SOPH) has 6 years of Gross Margin data on file, last reported at 67.68% in Q4 2025.
- For the quarter ending Q4 2025, Gross Margin fell 56.0% year-over-year to 67.68%; the trailing twelve-month figure through Dec 2025 stood at 67.4% (down 2.0% YoY), and the FY2025 full-year result was 67.4%, down 2.0% from the prior year.
- Gross Margin rose to 67.68% in Q4 2025, from 66.32% in the prior quarter.
- In the past five years, Gross Margin ranged from a high of 71.96% in Q4 2022 to a low of 61.21% in Q2 2021.
- A 5-year average of 66.36% and a median of 66.85% in 2023 frame the typical range for Gross Margin.
- Peak annual rise in Gross Margin reached 6317 bps in 2021, while the deepest fall reached 583 bps in 2021.
- Tracing SOPH's Gross Margin over 5 years: stood at 62.45% in 2021, then increased by 15 bps to 71.96% in 2022, then fell by 3 bps to 69.79% in 2023, then decreased by 2 bps to 68.25% in 2024, then declined by 1 bps to 67.68% in 2025.
- Business Quant data shows SOPH's Gross Margin at 67.68% in Q4 2025, 66.32% in Q3 2025, and 66.97% in Q2 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 31.70 Bn | 24.39 Bn | 662.02 Mn | 74.98% |
| 2 | BrightSpring Health Services | 14.70 Bn | 13.80 Bn | 482.22 Mn | 13.34% |
| 3 | Healthequity | 8.30 Bn | 8.04 Bn | 256.31 Mn | 72.27% |
| 4 | Hinge Health | 5.94 Bn | 5.62 Bn | 154.23 Mn | 84.60% |
| 5 | 10x Genomics | 5.86 Bn | 5.32 Bn | 106.18 Mn | 70.39% |
| 6 | MiniMed | 4.47 Bn | 4.17 Bn | 480.00 Mn | 57.35% |
| 7 | Waystar Holding | 4.45 Bn | 4.39 Bn | 216.84 Mn | 69.08% |
| 8 | Doximity | 3.94 Bn | 3.19 Bn | 125.97 Mn | 86.65% |
| 9 | Privia Health | 3.18 Bn | 2.76 Bn | - | - |
| 10 | SOPHiA GENETICS | 390.04 Mn | 319.75 Mn | 14.69 Mn | 67.68% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 67.68% |
| Sep 30, 2025 | 66.32% |
| Jun 30, 2025 | 66.97% |
| Mar 31, 2025 | 68.67% |
| Dec 31, 2024 | 68.25% |
| Sep 30, 2024 | 67.20% |
| Jun 30, 2024 | 68.17% |
| Mar 31, 2024 | 65.94% |
| Dec 31, 2023 | 69.79% |
| Sep 30, 2023 | 69.15% |
| Jun 30, 2023 | 66.74% |
| Mar 31, 2023 | 69.41% |
| Dec 31, 2022 | 71.96% |
| Sep 30, 2022 | 62.61% |
| Jun 30, 2022 | 65.31% |
| Mar 31, 2022 | 63.60% |
| Dec 31, 2021 | 62.45% |
| Sep 30, 2021 | 63.17% |
| Jun 30, 2021 | 61.21% |
| Mar 31, 2021 | 62.58% |