Sionna Therapeutics (SION) Operating Income (2024 - 2026)
Sionna Therapeutics (SION) posted Operating Income of -$29.6 million for Q1 2026, down 25.36% sequentially from -$23.6 million in Q4 2025, and down 50.56% YoY from -$59.9 million in Q1 2025.
Sionna Therapeutics (SION) Operating Income (2024 - 2026) Analysis & Trends
Sionna Therapeutics has reported Operating Income for 3 years, with the latest figure at -$29.6 million in Q1 2026.
- Quarterly Operating Income fell 50.56% year-over-year to -$29.6 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$98.9 million (down 28.36% YoY) and the FY2025 annual result came in at -$89.0 million, down 26.12% from the prior year.
- Operating Income fell to -$29.6 million in Q1 2026 per SION's latest filing, from -$23.6 million in the prior quarter.
- Over five years, Operating Income peaked at -$11.3 million in Q2 2024 and troughed at -$29.6 million in Q1 2026.
- A 3-year average of -$21.0 million and a median of -$21.9 million in 2025 frame the typical range for Operating Income.
- The widest YoY moves for Operating Income: up 14.93% in 2025, down 94.0% in 2025.
- Over 3 years, Operating Income stood at -$18.1 million in 2024, then sank by 30.22% to -$23.6 million in 2025, then retreated by 25.36% to -$29.6 million in 2026.
- According to Business Quant data, Operating Income over the past three periods registered -$29.6 million, -$23.6 million, and -$23.8 million for Q1 2026, Q4 2025, and Q3 2025 respectively.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Op. Inc (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 1.25 Bn |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 1.29 Bn |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 493.00 Mn |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | -505.13 Mn |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 325.05 Mn |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -3,158.03 |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 133.12 Mn |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 231.44 Mn |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -1.55 Mn |
| 10 | Sionna Therapeutics | 291.76 Mn | 291.76 Mn | - | -32.47 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -32.47 Mn |
| Mar 31, 2026 | -29.60 Mn |
| Dec 31, 2025 | -23.61 Mn |
| Sep 30, 2025 | -23.81 Mn |
| Jun 30, 2025 | -21.91 Mn |
| Mar 31, 2025 | -19.66 Mn |
| Dec 31, 2024 | -18.13 Mn |
| Sep 30, 2024 | -27.98 Mn |
| Jun 30, 2024 | -11.29 Mn |
| Mar 31, 2024 | -13.15 Mn |