Septerna (SEPN) Return on Sales [ROS] (2023 - 2026)
Septerna's Return on Sales [ROS] came in at -62.95% for Q2 2026, up 24288.31 percentage points from -24351.26% a year earlier but down 12.80 percentage points from the prior quarter.
Powered by 
Analysis
Septerna (SEPN) Return on Sales [ROS] (2023 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Septerna reported Return on Sales [ROS] of -44.04%, up 14027.04 percentage points year-over-year; for FY2025, it came in at -148.63%, up 7369.79 percentage points from FY2024.
- Going back by year, Return on Sales [ROS] was -7518.42% in FY2024 (-8892.59 pp) and 1374.17% in FY2023.
- The five-year range for quarterly Return on Sales [ROS] is -36484.85% (Q3 2023) to 29082.20% (Q4 2023).
- Year-over-year, Return on Sales [ROS] has increased for four consecutive quarters, with an average year-over-year change of +2125.52 percentage points over the last eight quarters.
- The fastest year-over-year change in Return on Sales [ROS] over five years came in Q2 2026 (a gain of 24288.31 percentage points), and the weakest in Q4 2024 (a drop of 40741.64 percentage points).
- Business Quant data shows SEPN's Return on Sales [ROS] at -50.15% (Q1 2026), -66.44% (Q4 2025) and 12.16% (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 28.37% |
| 10 | Septerna | 1.72 Bn | 1.72 Bn | - | -62.95% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -62.95% |
| Mar 31, 2026 | -50.15% |
| Dec 31, 2025 | -66.44% |
| Sep 30, 2025 | 12.16% |
| Jun 30, 2025 | -24,351.26% |
| Mar 31, 2025 | -11,831.05% |
| Dec 31, 2024 | -11,659.43% |
| Sep 30, 2024 | -12,812.50% |
| Jun 30, 2024 | -4,882.43% |
| Mar 31, 2024 | -4,886.44% |
| Dec 31, 2023 | 29,082.20% |
| Sep 30, 2023 | -36,484.85% |
API Access
Septerna Return on Sales [ROS] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=SEPN&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-sales-[ros]", "ticker": "SEPN", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=SEPN&period=max&api_key=YOUR_API_KEY");
const data = await res.json();