Septerna (SEPN) Return on Equity [ROE] (2024 - 2026)
Septerna (SEPN) reported Return on Equity [ROE] of -6.33% for Q2 2026, up 16.16 percentage points from -22.50% a year earlier and up 3.14 percentage points from the prior quarter.
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Analysis
Septerna (SEPN) Return on Equity [ROE] (2024 - 2026) Analysis & Trends
For FY2025, Septerna posted Return on Equity [ROE] of -12.19%, up 25.43 percentage points from FY2024.
- By year, Return on Equity [ROE] came in at -37.62% in FY2024.
- Year over year, Return on Equity [ROE] has now increased in each of the last three quarters.
- Per Business Quant data, the three quarters before Q2 2026 came in at -9.48% (Q1 2026), -12.69% (Q4 2025) and -15.35% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,175.39 Bn | 1,143.98 Bn | 19.71 Bn | 82.09% |
| 2 | Johnson & Johnson | 639.10 Bn | 557.63 Bn | 17.26 Bn | 25.32% |
| 3 | AbbVie | 502.70 Bn | 475.81 Bn | 12.70 Bn | - |
| 4 | Merck | 376.68 Bn | 331.05 Bn | 12.21 Bn | 7.21% |
| 5 | Novartis Ag | 304.33 Bn | 268.32 Bn | 11.24 Bn | 31.52% |
| 6 | Astrazeneca | 267.75 Bn | 241.43 Bn | 12.86 Bn | 21.39% |
| 7 | Amgen | 242.34 Bn | 197.73 Bn | 7.24 Bn | 83.75% |
| 8 | Gilead Sciences | 193.67 Bn | 167.87 Bn | 6.22 Bn | -18.38% |
| 9 | Pfizer | 172.62 Bn | 119.27 Bn | 10.94 Bn | 4.97% |
| 10 | Septerna | 1.86 Bn | 278.60 Mn | - | -6.33% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -6.33% |
| Mar 31, 2026 | -9.48% |
| Dec 31, 2025 | -12.69% |
| Sep 30, 2025 | -15.35% |
| Jun 30, 2025 | -22.50% |
| Mar 31, 2025 | -19.34% |
| Dec 31, 2024 | -43.41% |
API Access
Septerna Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SEPN&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "SEPN", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SEPN&period=max&api_key=YOUR_API_KEY");
const data = await res.json();