Septerna (SEPN) Return on Equity [ROE] (2024 - 2026)
Septerna (SEPN) reported Return on Equity [ROE] of -6.33% for Q2 2026, up 16.16 percentage points from -22.50% a year earlier and up 3.14 percentage points from the prior quarter.
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Analysis
Septerna (SEPN) Return on Equity [ROE] (2024 - 2026) Analysis & Trends
For FY2025, Septerna posted Return on Equity [ROE] of -12.19%, up 25.43 percentage points from FY2024.
- By year, Return on Equity [ROE] came in at -37.62% in FY2024.
- Year over year, Return on Equity [ROE] has now increased in each of the last three quarters.
- Per Business Quant data, the three quarters before Q2 2026 came in at -9.48% (Q1 2026), -12.69% (Q4 2025) and -15.35% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 25.32% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | - |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 7.21% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 84.40% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 21.39% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 83.75% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -18.38% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 4.97% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 22.24% |
| 10 | Septerna | 1.79 Bn | 1.79 Bn | - | -6.33% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -6.33% |
| Mar 31, 2026 | -9.48% |
| Dec 31, 2025 | -12.69% |
| Sep 30, 2025 | -15.35% |
| Jun 30, 2025 | -22.50% |
| Mar 31, 2025 | -19.34% |
| Dec 31, 2024 | -43.41% |
API Access
Septerna Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SEPN&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "SEPN", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SEPN&period=max&api_key=YOUR_API_KEY");
const data = await res.json();