Septerna (SEPN) Return on Capital Employed (2024 - 2026)
Septerna's quarterly Return on Capital Employed came in at 0.47% in Q1 2026, up 2146.0% year-on-year from 0.02% in Q1 2025, and up 123.32% quarter-over-quarter from 1.99% in Q4 2025.
Septerna has reported Return on Capital Employed for 3 years, with the latest figure at 0.47% in Q1 2026.
- For the quarter ending Q1 2026, Return on Capital Employed rose 2146.0% year-over-year to 0.47%; the trailing twelve-month figure through Mar 2026 stood at 0.47% (up 2146.0% YoY), and the FY2025 full-year result was 2.34%, up 2644.0% from the prior year.
- Return on Capital Employed for Q1 2026 stood at 0.47%, up from 1.99% in the prior quarter.
- The five-year high for Return on Capital Employed was 0.47% in Q1 2026, with the low at 26.71% in Q4 2024.
- Average Return on Capital Employed over 3 years is 15.31%, with a median of 19.33% recorded in 2025.
- Year-over-year, Return on Capital Employed soared 2472 bps in 2025 and surged 2146 bps in 2026.
- Tracing SEPN's Return on Capital Employed over 3 years: stood at 26.71% in 2024, then soared by 93 bps to 1.99% in 2025, then soared by 123 bps to 0.47% in 2026.
- The last three Return on Capital Employed figures came in at 0.47% (Q1 2026), 1.99% (Q4 2025), and 17.67% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | 450.31% |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 51.73% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | -107.40% |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 21.10% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 10.19% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 20.34% |
| 10 | Septerna | 1.34 Bn | 1.34 Bn | - | 0.47% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 0.47% |
| Dec 31, 2025 | -1.99% |
| Sep 30, 2025 | -17.67% |
| Jun 30, 2025 | -24.95% |
| Mar 31, 2025 | -20.99% |
| Dec 31, 2024 | -26.71% |