Septerna, Inc. (SEPN) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

45,602,099Shares Outstanding

50,779,059Shares held by institutions

$1,271,507,637Value of institutional holdings

111.35%Institutional ownership %

15.30%Shares Changed QoQ

120No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Septerna, Inc. (NASDAQ:SEPN) is held by 120 institutional investors per 13F filings through December 2025.

These investors held 102.4% of outstanding shares in December 2025, up from 97.8% in September 2025.
They increased total shares held in SEPN by 6.15% quarter over quarter, and investors in Septerna increased 69.01% from a year ago.
Of these 120 funds, 77 grew their exposure to Septerna, 25 cut back, and 18 maintained positions.
Combined, these investors held 46.71Mn shares in SEPN for December 2025, up by 2.71Mn shares quarter on quarter, and up 2.58Mn shares year over year.
As of December 31, 2025, RA CAPITAL MANAGEMENT, L.P. held the largest stake in Septerna with 7.0Mn shares, accounting for 15.34% of total shares outstanding.
Leading buyers of Septerna shares for the quarter ending December 2025 were Goldman Sachs Group Inc (3.98Mn), Avoro Capital Advisors LLC (1.34Mn), ADAR1 Capital Management, LLC (1.14Mn), First Light Asset Management, LLC (620.81K), PRIMECAP MANAGEMENT CO/CA/ (546.1K).
Top sellers of SEPN stock for the quarter ending December 2025 included BVF INC/IL (2.3Mn), MILLENNIUM MANAGEMENT LLC (276.74K), Siren, L.L.C. (202.51K), DRIEHAUS CAPITAL MANAGEMENT LLC (110.43K), PERCEPTIVE ADVISORS LLC (108.29K).
According to Business Quant data, leading holders of SEPN for December 2025 are RA CAPITAL MANAGEMENT, L.P. (7.0Mn), TRV GP V, LLC (6.22Mn), Goldman Sachs Group Inc (5.43Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (4.81Mn), TRV GP VI, LLC (4.21Mn), Samsara BioCapital, LLC (3.15Mn), Avoro Capital Advisors LLC (2.68Mn), ADAR1 Capital Management, LLC (2.32Mn), Siren, L.L.C. (2.0Mn), BlackRock, Inc. (1.8Mn).

120 Institutional Holders

50,779,059 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	6,995,858	0	0.00%	$195,044,521.00
TRV GP V, LLC	31 Dec, 2025	6,215,591	0	0.00%	$173,290,677.00
Goldman Sachs Group Inc	31 Dec, 2025	5,430,258	3,975,538	273.29%	$151,395,592.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	4,809,470	-110,426	-2.24%	$134,088,024.00
TRV GP VI, LLC	31 Dec, 2025	4,211,659	0	0.00%	$117,421,053.00
Samsara BioCapital, LLC	31 Dec, 2025	3,149,128	0	0.00%	$87,797,689.00
Avoro Capital Advisors LLC	31 Dec, 2025	2,675,000	1,337,500	100.00%	$74,579,000.00
ADAR1 Capital Management, LLC	31 Dec, 2025	2,315,222	1,138,731	96.79%	$64,548,390.00
Siren, L.L.C.	31 Dec, 2025	2,000,000	-202,514	-9.19%	$55,760,000.00
BlackRock, Inc.	31 Dec, 2025	1,801,328	341,533	23.40%	$50,221,023.00
BVF INC/IL	31 Dec, 2025	1,720,782	-2,295,008	-57.15%	$47,975,402.00
VANGUARD GROUP INC	31 Dec, 2025	1,508,195	-10,562	-0.70%	$42,048,476.00
First Light Asset Management, LLC	31 Dec, 2025	620,811	620,811	0.00%	$17,308,211.00
VR Adviser, LLC	31 Dec, 2025	610,808	0	0.00%	$17,029,327.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	572,734	27,033	4.95%	$15,971,458.00
Casdin Capital, LLC	31 Dec, 2025	553,268	0	0.00%	$15,425,112.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	546,100	546,100	0.00%	$15,225,268.00
State Street Corp	31 Dec, 2025	540,028	121,068	28.90%	$15,055,981.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	433,160	-108,290	-20.00%	$12,076,501.00
Woodline Partners LP	31 Dec, 2025	385,310	102,725	36.35%	$10,742,443.00

1 - 20 of 120

Research Tools