Septerna, Inc. (SEPN) Institutional Ownership

Ownership Summary

A total of 83 institutions have reported a stake in Septerna, Inc. (NASDAQ:SEPN) as of September 2025, according to recent 13F filings with the SEC.

• These investors collectively held 100.7% of the company's total shares outstanding in September 2025, up from 100.7% in June 2025.
• Institutional share ownership changed by 1.06% QoQ, while the number of institutional owners saw an unavailable change YoY.
• Of these 83 institutional investors, 40 increased their holdings in Septerna, while 20 of them reduced positions, and 23 investors maintained their exposure.
• Collectively, institutional investors increased their stake in Septerna to 44.90Mn shares as of September 2025, a change that is up by 471.62K shares quarter on quarter and down N/A shares year over year.
• As of September 30, 2025, RA CAPITAL MANAGEMENT, L.P. held Septerna's largest shareholding position with over 7.00Mn shares, representing 15.69% of total outstanding shares.
• Among the most significant buyers of Septerna during September 2025 were MILLENNIUM MANAGEMENT LLC (332.26K), ADAR1 Capital Management, LLC (329.26K), DRIEHAUS CAPITAL MANAGEMENT LLC (239.47K), Invesco Ltd. (165.24K), VANGUARD GROUP INC (104.39K).
• Leading sellers of Septerna stock in September 2025 included Sio Capital Management, LLC (395.24K), BVF INC/IL (380.33K), Checkpoint Capital L.P. (303.31K), JANE STREET GROUP, LLC (95.90K), Soleus Capital Management, L.P. (57.20K).
• The top 10 institutional holders of Septerna for the quarter ending September 2025 included RA CAPITAL MANAGEMENT, L.P. (7.00Mn), TRV GP V, LLC (6.22Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (4.92Mn), TRV GP VI, LLC (4.21Mn), BVF INC/IL (4.02Mn), Samsara BioCapital, LLC (3.15Mn), Siren, L.L.C. (2.20Mn), VANGUARD GROUP INC (1.52Mn), BlackRock, Inc. (1.46Mn), GOLDMAN SACHS GROUP INC (1.45Mn).