Septerna SEPN Institutional Ownership

NASDAQ SEPN

$39.13 +0.00 (+0.00%)

At close: Sep 30, 2026 · 4:00 PM EDT

Institutions by Trading Activity

155 Institutions

Increased 98 63.2%

Unchanged 25 16.1%

Reduced 32 20.6%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

105.31%

▲+3.15 pp QoQ

Shares Held by Institutions

47.43Mn

of 45.04Mn outstanding

▲+11.05% QoQ

Shares Outstanding

45.04Mn

-2.39Mn held outside 13F filers

Institutional Investors

155

filed 13F for Jun 2026

▲+31 vs prior quarter

Net Shares Added (QoQ)

+4.72Mn

accumulated since last quarter

Value of Holdings

$1.86Bn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Quarter ending 30 Jun, 2026

Septerna, Inc. (NASDAQ:SEPN) has 155 institutional investors with active 13F positions as of June 2026.

Collectively, these holders controlled 105.3% of Septerna's outstanding shares in June 2026, up from 102.2% in March 2026.
They increased total shares held in Septerna by 11.05% from last quarter, and the number of investors in SEPN increased 78.16% annually.
Of these 155 funds, 98 grew their exposure to Septerna, 32 cut back, and 25 maintained positions.
Combined, these investors held 47.43Mn shares in SEPN for June 2026, up by 4.72Mn shares quarter on quarter, and up 3.1Mn shares year over year.
As of June 30, 2026, the biggest holder of Septerna is RA CAPITAL MANAGEMENT, L.P. at 7.0Mn shares, representing 15.53% of shares outstanding.
Leading buyers of Septerna shares for the quarter ending June 2026 were Jupiter Topco LLC (1.31Mn), LOOMIS SAYLES & CO L P (624.75K), ALGERT GLOBAL LLC (376.45K), Catalio Capital Management, LP (241.79K), First Light Asset Management, LLC (230.4K).
The largest sellers of Septerna for the quarter ending June 2026 were ADAR1 Capital Management, LLC (149.07K), Siren, L.L.C. (100.0K), MILLENNIUM MANAGEMENT LLC (73.54K), Invesco Ltd. (58.77K), HUSSMAN STRATEGIC ADVISORS, INC. (42.0K).
Septerna's 10 largest shareholders as of June 2026 include RA CAPITAL MANAGEMENT, L.P. (7.0Mn), TRV GP V, LLC (6.22Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (4.43Mn), TRV GP VI, LLC (4.21Mn), Samsara BioCapital, LLC (3.15Mn), Goldman Sachs Group Inc (3.06Mn), BlackRock, Inc. (1.93Mn), Siren, L.L.C. (1.9Mn), Avoro Capital Advisors LLC (1.34Mn), Jupiter Topco LLC (1.31Mn) per Business Quant data.

Form 13F Holdings

155 Institutional Holders

Report period 30 Jun, 2026

Total shares held 47.43Mn

Of outstanding 105.31%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	RA CAPITAL MANAGEMENT, L.P.	0001346824	6,995,858	15.53%	0	0.00%	$234.29Mn
2	TRV GP V, LLC	0001990717	6,215,591	13.80%	0	0.00%	$208.16Mn
3	DRIEHAUS CAPITAL MANAGEMENT LLC	0000938206	4,433,058	9.84%	▲37,486	+0.85%	$148.46Mn
4	TRV GP VI, LLC	0001990716	4,211,659	9.35%	0	0.00%	$141.05Mn
5	Samsara BioCapital, LLC	0001744967	3,149,128	6.99%	0	0.00%	$105.46Mn
6	Goldman Sachs Group Inc	0000886982	3,062,766	6.80%	▲156,339	+5.38%	$102.57Mn
7	BlackRock, Inc.	0002012383	1,932,088	4.29%	▲109,914	+6.03%	$64.71Mn
8	Siren, L.L.C.	0002005245	1,900,000	4.22%	▼100,000	-5.00%	$63.63Mn
9	Avoro Capital Advisors LLC	0001633313	1,337,500	2.97%	0	0.00%	$44.79Mn
10	Jupiter Topco LLC	0002146052	1,307,500	2.90%	▲1,307,500	0.00%	$43.72Mn
11	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	1,221,673	2.71%	▲24,711	+2.06%	$40.91Mn
12	PRIMECAP MANAGEMENT CO/CA/	0000763212	1,167,382	2.59%	▲118,548	+11.30%	$39.10Mn
13	First Light Asset Management, LLC	0001600004	963,260	2.14%	▲230,400	+31.44%	$32.26Mn
14	ADAR1 Capital Management, LLC	0001940272	940,747	2.09%	▼149,071	-13.68%	$31.51Mn
15	GEODE CAPITAL MANAGEMENT, LLC	0001214717	679,163	1.51%	▲34,017	+5.27%	$22.75Mn
16	State Street Corp	0000093751	652,630	1.45%	▲21,183	+3.35%	$21.86Mn
17	LOOMIS SAYLES & CO L P	0000312348	624,752	1.39%	▲624,752	0.00%	$20.92Mn
18	Casdin Capital, LLC	0001534261	553,268	1.23%	0	0.00%	$18.53Mn
19	Catalio Capital Management, LP	0001958125	536,152	1.19%	▲241,792	+82.14%	$17.96Mn
20	ALGERT GLOBAL LLC	0001275218	397,487	0.88%	▲376,452	+1,789.65%	$13.31Mn

Showing 1 to 20 of 155 holders