Septerna, Inc. (SEPN) Institutional Ownership

Institutions by Trading Activity

-4,280,131Shares Outstanding

23,649,216Shares held by institutions

$716,571,245Value of institutional holdings

0.00%Institutional ownership %

3.02%Shares Changed QoQ

118No. of institutional investors

According to SEC filings for the period ending December 2025, Septerna, Inc. (NASDAQ:SEPN) is held by 118 institutional firms.

On a quarter-over-quarter basis, institutional holdings shifted by 3.02%, with a year-over-year an increase of 66.20% in the count of filers.
Of these 118 institutional investors, 74 increased their holdings in Septerna, while 26 of them reduced positions, and 18 investors maintained their exposure.
Collectively, institutional investors increased their stake in Septerna to 45.46Mn shares as of December 2025, a change that is up by 1.33Mn shares quarter on quarter and up 1.40Mn shares year over year.
Among the most significant buyers of Septerna during December 2025 were GOLDMAN SACHS GROUP INC (1.26Mn), First Light Asset Management, LLC (620.81K), PRIMECAP MANAGEMENT CO/CA/ (546.10K), Soleus Capital Management, L.P. (365.11K), BlackRock, Inc. (341.53K).
Leading sellers of Septerna stock in December 2025 included BVF INC/IL (2.30Mn), MILLENNIUM MANAGEMENT LLC (276.74K), JANE STREET GROUP, LLC (228.13K), Siren, L.L.C. (202.51K), DRIEHAUS CAPITAL MANAGEMENT LLC (110.43K).

23,649,216 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	6,995,858	0	0.00%	$195,044,521.00
TRV GP V, LLC	31 Dec, 2025	6,215,591	0	0.00%	$173,290,677.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	4,809,470	-110,426	-2.24%	$134,088,024.00
TRV GP VI, LLC	31 Dec, 2025	4,211,659	0	0.00%	$117,421,053.00
Samsara BioCapital, LLC	31 Dec, 2025	3,149,128	0	0.00%	$87,797,689.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	2,715,129	1,260,409	86.64%	$75,697,796.00
Siren, L.L.C.	31 Dec, 2025	2,000,000	-202,514	-9.19%	$55,760,000.00
BlackRock, Inc.	31 Dec, 2025	1,801,328	341,533	23.40%	$50,221,023.00
BVF INC/IL	31 Dec, 2025	1,720,782	-2,295,008	-57.15%	$47,975,402.00
VANGUARD GROUP INC	31 Dec, 2025	1,508,195	-10,562	-0.70%	$42,048,476.00
Avoro Capital Advisors LLC	31 Dec, 2025	1,337,500	0	0.00%	$37,289,500.00
ADAR1 Capital Management, LLC	31 Dec, 2025	1,157,611	-18,880	-1.60%	$32,274,195.00
First Light Asset Management, LLC	31 Dec, 2025	620,811	620,811	0.00%	$17,308,211.00
VR Adviser, LLC	31 Dec, 2025	610,808	0	0.00%	$17,029,327.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	572,734	27,033	4.95%	$15,971,458.00
Casdin Capital, LLC	31 Dec, 2025	553,268	0	0.00%	$15,425,112.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	546,100	546,100	0.00%	$15,225,268.00
STATE STREET CORP	31 Dec, 2025	540,028	121,068	28.90%	$15,055,981.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	433,160	-108,290	-20.00%	$12,076,501.00
Woodline Partners LP	31 Dec, 2025	385,310	102,725	36.35%	$10,742,443.00

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