Septerna, Inc. (SEPN) Institutional Ownership

Institutions by Trading Activity

45,602,099Shares Outstanding

50,779,059Shares held by institutions

$1,257,797,291Value of institutional holdings

111.35%Institutional ownership %

15.30%Shares Changed QoQ

120No. of institutional investors

Septerna, Inc. (NASDAQ:SEPN) showed up in the 13F filings of 120 institutional investors as of December 2025.

These investors collectively held 102.4% of Septerna's outstanding shares in December 2025, up from 97.8% in September 2025.
Their total shares held in SEPN increased 6.15% quarter over quarter, and separately, investors owning Septerna increased 69.01% from a year ago.
Among the 120 funds, 77 bought more Septerna shares, 25 sold down, and 18 held their ground.
The aggregate institutional position in Septerna amounted to 46.71Mn shares as of December 2025, up by 2.71Mn shares quarter on quarter, and up 2.58Mn shares year over year.
As of December 31, 2025, STRS OHIO held the largest stake in Septerna with 17.2K shares, accounting for 0.04% of total shares outstanding.
Top purchasers of SEPN stock for the quarter ending December 2025 included STRS OHIO (2.6K), GAMMA Investing LLC (194), GF FUND MANAGEMENT CO. LTD. (128), MassMutual Private Wealth & Trust, FSB (72), Farther Finance Advisors, LLC (6).
The largest sales of SEPN for the quarter ending December 2025 came from Sterling Capital Management LLC (520), Fortitude Family Office, LLC (51), SIGNATUREFD, LLC (23).
Per Business Quant data, the top 9 holders of Septerna for the quarter ending December 2025 are STRS OHIO (17.2K), GAMMA Investing LLC (1.11K), GF FUND MANAGEMENT CO. LTD. (1.01K), SIGNATUREFD, LLC (966), Sterling Capital Management LLC (712), Versant Capital Management, Inc (261), MassMutual Private Wealth & Trust, FSB (135), Fortitude Family Office, LLC (20), Farther Finance Advisors, LLC (7).

50,779,059 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	6,995,858	0	0.00%	$195,044,521.00
TRV GP V, LLC	31 Dec, 2025	6,215,591	0	0.00%	$173,290,677.00
Goldman Sachs Group Inc	31 Dec, 2025	5,430,258	3,975,538	273.29%	$151,395,592.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	4,809,470	-110,426	-2.24%	$134,088,024.00
TRV GP VI, LLC	31 Dec, 2025	4,211,659	0	0.00%	$117,421,053.00
Samsara BioCapital, LLC	31 Dec, 2025	3,149,128	0	0.00%	$87,797,689.00
Avoro Capital Advisors LLC	31 Dec, 2025	2,675,000	1,337,500	100.00%	$74,579,000.00
ADAR1 Capital Management, LLC	31 Dec, 2025	2,315,222	1,138,731	96.79%	$64,548,390.00
Siren, L.L.C.	31 Dec, 2025	2,000,000	-202,514	-9.19%	$55,760,000.00
BlackRock, Inc.	31 Dec, 2025	1,801,328	341,533	23.40%	$50,221,023.00
BVF INC/IL	31 Dec, 2025	1,720,782	-2,295,008	-57.15%	$47,975,402.00
VANGUARD GROUP INC	31 Dec, 2025	1,508,195	-10,562	-0.70%	$42,048,476.00
First Light Asset Management, LLC	31 Dec, 2025	620,811	620,811	0.00%	$17,308,211.00
VR Adviser, LLC	31 Dec, 2025	610,808	0	0.00%	$17,029,327.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	572,734	27,033	4.95%	$15,971,458.00
Casdin Capital, LLC	31 Dec, 2025	553,268	0	0.00%	$15,425,112.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	546,100	546,100	0.00%	$15,225,268.00
State Street Corp	31 Dec, 2025	540,028	121,068	28.90%	$15,055,981.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	433,160	-108,290	-20.00%	$12,076,501.00
Woodline Partners LP	31 Dec, 2025	385,310	102,725	36.35%	$10,742,443.00

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