Septerna, Inc. (SEPN) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

25,571,961Shares held by institutions

$595,570,972Value of institutional holdings

100.57%Institutional ownership %

-11.67%Shares Changed QoQ

87No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Septerna, Inc. (NASDAQ:SEPN) has 120 institutional investors with active 13F positions as of December 2025.

Their combined ownership stood at 102.4% of outstanding shares in December 2025, up from 97.8% in September 2025.
They increased total shares held in SEPN by 6.15% quarter over quarter, and investors in Septerna increased 69.01% from a year ago.
Activity in SEPN broke down as 77 buyers, 25 sellers, and 18 unchanged among 120 total holders.
Altogether, these fund groups held 46.71Mn shares in SEPN by December 2025, up by 2.71Mn shares quarter on quarter, and up 2.58Mn shares year over year.
As of December 31, 2025, the biggest holder of Septerna is RA CAPITAL MANAGEMENT, L.P. at 7.0Mn shares, representing 15.34% of shares outstanding.
The largest buyers of Septerna for the quarter ending December 2025 were Goldman Sachs Group Inc (1.26Mn), ADAR1 Capital Management, LLC (1.14Mn), First Light Asset Management, LLC (620.81K), PRIMECAP MANAGEMENT CO/CA/ (546.1K), Soleus Capital Management, L.P. (365.11K).
Leading sellers of Septerna shares for the quarter ending December 2025 were BVF INC/IL (2.3Mn), MILLENNIUM MANAGEMENT LLC (276.74K), Siren, L.L.C. (202.51K), DRIEHAUS CAPITAL MANAGEMENT LLC (110.43K), PERCEPTIVE ADVISORS LLC (108.29K).
Business Quant data shows the 10 biggest positions in Septerna as of December 2025 are held by RA CAPITAL MANAGEMENT, L.P. (7.0Mn), TRV GP V, LLC (6.22Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (4.81Mn), TRV GP VI, LLC (4.21Mn), Samsara BioCapital, LLC (3.15Mn), Goldman Sachs Group Inc (2.72Mn), ADAR1 Capital Management, LLC (2.32Mn), Siren, L.L.C. (2.0Mn), BlackRock, Inc. (1.8Mn), BVF INC/IL (1.72Mn).

120 Institutional Holders

25,571,961 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	341,533	23.40%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	0	0.00%	$0.00
TRV GP V, LLC	31 Dec, 2025	0	0.00%	$0.00
Avoro Capital Advisors LLC	31 Dec, 2025	1,337,500	100.00%	$0.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	-110,426	-2.24%	$0.00
TRV GP VI, LLC	31 Dec, 2025	0	0.00%	$0.00
Barclays Plc	31 Dec, 2025	8,045	26.73%	$0.00
Goldman Sachs Group Inc	31 Dec, 2025	1,260,409	86.64%	$0.00
Samsara BioCapital, LLC	31 Dec, 2025	0	0.00%	$0.00
BVF INC/IL	31 Dec, 2025	-2,295,008	-57.15%	$0.00
ADAR1 Capital Management, LLC	31 Dec, 2025	1,138,731	96.79%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	-10,562	-0.70%	$0.00
Siren, L.L.C.	31 Dec, 2025	-202,514	-9.19%	$0.00
First Light Asset Management, LLC	31 Dec, 2025	620,811	0.00%	$0.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	27,033	4.95%	$0.00
VR Adviser, LLC	31 Dec, 2025	0	0.00%	$0.00
Casdin Capital, LLC	31 Dec, 2025	0	0.00%	$0.00
Woodline Partners LP	31 Dec, 2025	102,725	36.35%	$0.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	546,100	0.00%	$0.00
Soleus Capital Management, L.P.	31 Dec, 2025	365,108	1,999.50%	$0.00

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