Septerna (SEPN) Operating Income (2023 - 2026)

Septerna's Operating Income history runs 4 years deep, the most recent figure standing at -$13.3 million for Q1 2026.

• In Q1 2026, Operating Income rose 48.67% year-over-year to -$13.3 million; the TTM figure through Mar 2026 stood at $2.3 million (up 102.57% YoY), while the FY2025 annual figure was -$10.3 million, up 87.3% from the prior year.
• Operating Income was -$13.3 million for Q1 2026 at Septerna, down from $42.0 million in the prior quarter.
• In the past five years, Operating Income ranged from a high of $42.0 million in Q4 2025 to a low of -$29.0 million in Q2 2025.
• Historically, Operating Income has averaged -$7.5 million across 4 years, with a median of -$15.5 million in 2024.
• The sharpest annual moves came in 2024 and 2025: Operating Income plunged 172.03% in 2024, then jumped 269.97% in 2025.
• A 4-year view of Operating Income shows it stood at $34.3 million in 2023, then sank by 172.03% to -$24.7 million in 2024, then surged by 269.97% to $42.0 million in 2025, then tumbled by 131.66% to -$13.3 million in 2026.
• The last three Operating Income figures came in at -$13.3 million (Q1 2026), $42.0 million (Q4 2025), and $2.6 million (Q3 2025), per Business Quant data.