Septerna (SEPN) Operating Income (2023 - 2025)

Septerna has reported Operating Income over the past 3 years, most recently at -$16.0 million for Q4 2025.

  • Quarterly results put Operating Income at -$16.0 million for Q4 2025, up 35.18% from a year ago — trailing twelve months through Dec 2025 was -$68.3 million (up 15.5% YoY), and the annual figure for FY2025 was -$68.3 million, up 15.5%.
  • Operating Income for Q4 2025 was -$16.0 million at Septerna, down from $2.6 million in the prior quarter.
  • Over the last five years, Operating Income for SEPN hit a ceiling of $34.3 million in Q4 2023 and a floor of -$29.0 million in Q2 2025.
  • Median Operating Income over the past 3 years was -$17.0 million (2024), compared with a mean of -$12.7 million.
  • Biggest five-year swings in Operating Income: tumbled 172.03% in 2024 and later soared 111.59% in 2025.
  • Septerna's Operating Income stood at $34.3 million in 2023, then tumbled by 172.03% to -$24.7 million in 2024, then soared by 35.18% to -$16.0 million in 2025.
  • The last three reported values for Operating Income were -$16.0 million (Q4 2025), $2.6 million (Q3 2025), and -$29.0 million (Q2 2025) per Business Quant data.