Septerna (SEPN) Net Income (2023 - 2026)

Septerna's (SEPN) quarterly Net Income came in at -$8.6 million in Q1 2026, up 59.78% year-on-year from -$5.4 million in Q1 2025, and up 19.57% quarter-over-quarter from -$10.7 million in Q4 2025.

Septerna (SEPN) Net Income (2023 - 2026) Analysis & Trends

Septerna's Net Income history runs 4 years deep, the most recent figure standing at -$8.6 million for Q1 2026.

  • On a quarterly basis, Net Income rose 59.78% year-over-year to -$8.6 million in Q1 2026; TTM through Mar 2026 was -$36.0 million, a 54.57% increase from a year earlier, with the FY2025 full-year figure at -$48.9 million, up 31.92% from the prior year.
  • Net Income grew to -$8.6 million in Q1 2026 per SEPN's latest filing, from -$10.7 million in the prior quarter.
  • Across five years, Net Income topped out at $8.2 million in Q3 2025 and bottomed at -$24.8 million in Q2 2025.
  • The 4-year median for Net Income is -$16.7 million (2024), against an average of -$14.4 million.
  • Across the five-year window, Net Income sank 87.51% in 2024 and surged 139.82% in 2025, its largest moves.
  • Year by year, Net Income stood at -$18.2 million in 2023, then slipped by 13.85% to -$20.7 million in 2024, then jumped by 48.05% to -$10.7 million in 2025, then rose by 19.57% to -$8.6 million in 2026.
  • Per Business Quant, the three latest SEPN Net Income figures stand at -$8.6 million (Q1 2026), -$10.7 million (Q4 2025), and $8.2 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Net Income (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -37.09 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 227.36 Mn
4 NuCana 279.75 Bn 279.75 Bn - -3.31 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.03 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 727.20 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -26.94 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 362.00 Mn
9 Revolution Medicines 37.78 Bn 37.78 Bn - -453.82 Mn
10 Septerna 1.50 Bn 1.50 Bn - -8.64 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -8.64 Mn
Dec 31, 2025 -10.74 Mn
Sep 30, 2025 8.17 Mn
Jun 30, 2025 -24.84 Mn
Mar 31, 2025 -21.48 Mn
Dec 31, 2024 -20.67 Mn
Sep 30, 2024 -20.52 Mn
Jun 30, 2024 -16.66 Mn
Mar 31, 2024 -14.35 Mn
Dec 31, 2023 -18.15 Mn
Sep 30, 2023 -10.95 Mn