Septerna (SEPN) EBT (2023 - 2026)

Septerna's (SEPN) quarterly EBT came in at -$8.3 million in Q1 2026, up 61.35% year-on-year from -$5.1 million in Q1 2025, and up 22.62% quarter-over-quarter from -$10.7 million in Q4 2025.

Septerna (SEPN) EBT (2023 - 2026) Analysis & Trends

Septerna's EBT history runs 4 years deep, the most recent figure standing at -$8.3 million for Q1 2026.

  • On a quarterly basis, EBT rose 61.35% year-over-year to -$8.3 million in Q1 2026; TTM through Mar 2026 was -$35.7 million, a 55.11% increase from a year earlier, with the FY2025 full-year figure at -$48.9 million, up 32.41% from the prior year.
  • EBT advanced to -$8.3 million in Q1 2026 per SEPN's latest filing, from -$10.7 million in the prior quarter.
  • Across five years, EBT topped out at $8.2 million in Q3 2025 and bottomed at -$24.8 million in Q2 2025.
  • The 4-year median for EBT is -$16.6 million (2024), against an average of -$14.4 million.
  • Across the five-year window, EBT plunged 88.75% in 2024 and jumped 139.56% in 2025, its largest moves.
  • Year by year, EBT stood at -$18.2 million in 2023, then fell by 14.74% to -$20.8 million in 2024, then surged by 48.5% to -$10.7 million in 2025, then gained by 22.62% to -$8.3 million in 2026.
  • Per Business Quant, the three latest SEPN EBT figures stand at -$8.3 million (Q1 2026), -$10.7 million (Q4 2025), and $8.2 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -36.97 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -15.31 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 259.22 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.25 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 831.20 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -26.94 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 438.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - -453.82 Mn
10 Septerna 1.48 Bn 1.48 Bn - -8.30 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -8.30 Mn
Dec 31, 2025 -10.73 Mn
Sep 30, 2025 8.17 Mn
Jun 30, 2025 -24.84 Mn
Mar 31, 2025 -21.48 Mn
Dec 31, 2024 -20.83 Mn
Sep 30, 2024 -20.66 Mn
Jun 30, 2024 -16.55 Mn
Mar 31, 2024 -14.26 Mn
Dec 31, 2023 -18.15 Mn
Sep 30, 2023 -10.95 Mn