Septerna (SEPN) EBITDA (2023 - 2026)
Septerna (SEPN) posted quarterly EBITDA of -$13.3 million for Q1 2026, up 48.67% year-over-year from -$8.9 million in Q1 2025, and up 16.99% quarter-over-quarter from -$16.0 million in Q4 2025.
Septerna (SEPN) EBITDA (2023 - 2026) Analysis & Trends
Septerna's EBITDA history runs 4 years deep, the most recent figure standing at -$13.3 million for Q1 2026.
- In Q1 2026, EBITDA rose 48.67% year-over-year to -$13.3 million; the TTM figure through Mar 2026 stood at -$55.7 million (up 38.97% YoY), while the FY2025 annual figure was -$68.3 million, up 15.5% from the prior year.
- EBITDA for Q1 2026 stood at -$13.3 million, up from -$16.0 million in the prior quarter.
- The five-year high for EBITDA was $34.3 million in Q4 2023, with the low at -$29.0 million in Q2 2025.
- The 4-year median for EBITDA is -$16.0 million (2025), against an average of -$12.7 million.
- The sharpest annual moves came in 2024 and 2025: EBITDA tumbled 172.03% in 2024, then soared 111.59% in 2025.
- Septerna's EBITDA stood at $34.3 million in 2023, then plunged by 172.03% to -$24.7 million in 2024, then jumped by 35.18% to -$16.0 million in 2025, then rose by 16.99% to -$13.3 million in 2026.
- Business Quant data shows SEPN's EBITDA at -$13.3 million in Q1 2026, -$16.0 million in Q4 2025, and $2.6 million in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 1.25 Bn |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 1.29 Bn |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 493.00 Mn |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | -505.13 Mn |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 325.05 Mn |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -2.33 Bn |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 133.12 Mn |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 231.44 Mn |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -1.55 Mn |
| 10 | Septerna | 2.08 Bn | 2.08 Bn | - | -16.84 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -16.84 Mn |
| Mar 31, 2026 | -13.30 Mn |
| Dec 31, 2025 | -16.02 Mn |
| Sep 30, 2025 | 2.61 Mn |
| Jun 30, 2025 | -28.98 Mn |
| Mar 31, 2025 | -25.91 Mn |
| Dec 31, 2024 | -24.72 Mn |
| Sep 30, 2024 | -22.55 Mn |
| Jun 30, 2024 | -18.07 Mn |
| Mar 31, 2024 | -15.49 Mn |
| Dec 31, 2023 | 34.32 Mn |
| Sep 30, 2023 | -12.04 Mn |