Septerna (SEPN) EBITDA (2023 - 2026)
Septerna's quarterly EBITDA came in at -$9.8 million in Q1 2026, up 53.96% year-on-year from -$6.4 million in Q1 2025, and down 123.38% quarter-over-quarter from $42.0 million in Q4 2025.
Septerna has reported EBITDA for 4 years, with the latest figure at -$9.8 million in Q1 2026.
- For the quarter ending Q1 2026, EBITDA rose 53.96% year-over-year to -$9.8 million; the trailing twelve-month figure through Mar 2026 stood at $15.7 million (up 118.96% YoY), and the FY2025 full-year result was -$10.3 million, up 87.3% from the prior year.
- EBITDA for Q1 2026 stood at -$9.8 million, down from $42.0 million in the prior quarter.
- The five-year high for EBITDA was $42.0 million in Q4 2025, with the low at -$24.9 million in Q2 2025.
- Average EBITDA over 4 years is -$5.3 million, with a median of -$14.2 million recorded in 2024.
- Year-over-year, EBITDA plunged 172.03% in 2024 and soared 269.97% in 2025.
- Tracing SEPN's EBITDA over 4 years: stood at $34.3 million in 2023, then plunged by 172.03% to -$24.7 million in 2024, then soared by 269.97% to $42.0 million in 2025, then plunged by 123.38% to -$9.8 million in 2026.
- The last three EBITDA figures came in at -$9.8 million (Q1 2026), $42.0 million (Q4 2025), and $8.4 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | -13.63 Mn |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -19.70 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | -14.44 Mn |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 1.14 Bn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | -3.82 Mn |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 661.60 Mn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 201.19 Mn |
| 10 | Septerna | 1.34 Bn | 1.34 Bn | - | -9.82 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -9.82 Mn |
| Dec 31, 2025 | 42.01 Mn |
| Sep 30, 2025 | 8.37 Mn |
| Jun 30, 2025 | -24.86 Mn |
| Mar 31, 2025 | -21.33 Mn |
| Dec 31, 2024 | -24.72 Mn |
| Sep 30, 2024 | -20.34 Mn |
| Jun 30, 2024 | -16.44 Mn |
| Mar 31, 2024 | -14.17 Mn |
| Dec 31, 2023 | 34.32 Mn |
| Sep 30, 2023 | -10.95 Mn |