Septerna (SEPN) EBITDA (2023 - 2025)

Septerna (SEPN) has 3 years of EBITDA data on record, last reported at $42.0 million in Q4 2025.

  • For Q4 2025, EBITDA rose 269.97% year-over-year to $42.0 million; the TTM value through Dec 2025 reached $4.2 million, up 105.54%, while the annual FY2025 figure was -$10.3 million, 87.3% up from the prior year.
  • EBITDA reached $42.0 million in Q4 2025 per SEPN's latest filing, up from $8.4 million in the prior quarter.
  • Across five years, EBITDA topped out at $42.0 million in Q4 2025 and bottomed at -$24.9 million in Q2 2025.
  • Average EBITDA over 3 years is -$4.8 million, with a median of -$15.3 million recorded in 2024.
  • Peak YoY movement for EBITDA: crashed 172.03% in 2024, then skyrocketed 269.97% in 2025.
  • A 3-year view of EBITDA shows it stood at $34.3 million in 2023, then plummeted by 172.03% to -$24.7 million in 2024, then surged by 269.97% to $42.0 million in 2025.
  • Per Business Quant database, its latest 3 readings for EBITDA were $42.0 million in Q4 2025, $8.4 million in Q3 2025, and -$24.9 million in Q2 2025.