Septerna (SEPN) EBITDA (2023 - 2026)

Septerna's EBITDA history runs 4 years deep, the most recent figure standing at -$9.8 million for Q1 2026.

• In Q1 2026, EBITDA rose 53.96% year-over-year to -$9.8 million; the TTM figure through Mar 2026 stood at $15.7 million (up 118.96% YoY), while the FY2025 annual figure was -$10.3 million, up 87.3% from the prior year.
• EBITDA was -$9.8 million for Q1 2026 at Septerna, down from $42.0 million in the prior quarter.
• In the past five years, EBITDA ranged from a high of $42.0 million in Q4 2025 to a low of -$24.9 million in Q2 2025.
• Historically, EBITDA has averaged -$5.3 million across 4 years, with a median of -$14.2 million in 2024.
• The sharpest annual moves came in 2024 and 2025: EBITDA plunged 172.03% in 2024, then jumped 269.97% in 2025.
• A 4-year view of EBITDA shows it stood at $34.3 million in 2023, then sank by 172.03% to -$24.7 million in 2024, then surged by 269.97% to $42.0 million in 2025, then sank by 123.38% to -$9.8 million in 2026.
• The last three EBITDA figures came in at -$9.8 million (Q1 2026), $42.0 million (Q4 2025), and $8.4 million (Q3 2025), per Business Quant data.