Revolution Medicines (RVMD) Operating Income (2019 - 2026)

Revolution Medicines' quarterly Operating Income came in at -$445.2 million in Q1 2026, down 84.92% year-on-year from -$3.0 billion in Q1 2025, and down 176.35% quarter-over-quarter from $583.2 million in Q4 2025.

Revolution Medicines has reported Operating Income for 8 years, with the latest figure at -$445.2 million in Q1 2026.

  • For the quarter ending Q1 2026, Operating Income fell 84.92% year-over-year to -$445.2 million; the trailing twelve-month figure through Mar 2026 stood at -$442.0 million (up 44.01% YoY), and the FY2025 full-year result was -$237.6 million, up 65.55% from the prior year.
  • Operating Income for Q1 2026 stood at -$445.2 million, down from $583.2 million in the prior quarter.
  • The five-year high for Operating Income was $583.2 million in Q4 2025, with the low at -$445.2 million in Q1 2026.
  • Average Operating Income over 5 years is -$124.6 million, with a median of -$140.9 million recorded in 2024.
  • Year-over-year, Operating Income plunged 191.67% in 2023 and surged 369.6% in 2025.
  • Tracing RVMD's Operating Income over 5 years: stood at -$61.7 million in 2022, then sank by 191.67% to -$180.0 million in 2023, then declined by 20.18% to -$216.3 million in 2024, then surged by 369.6% to $583.2 million in 2025, then sank by 176.35% to -$445.2 million in 2026.
  • The last three Operating Income figures came in at -$445.2 million (Q1 2026), $583.2 million (Q4 2025), and -$315.3 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -2.97 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -15.76 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.14 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 642.90 Mn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 268.64 Mn
10 Revolution Medicines 32.39 Bn 32.39 Bn - -445.22 Mn

Historic Data

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DateValue
Mar 31, 2026 -445.22 Mn
Dec 31, 2025 583.17 Mn
Sep 30, 2025 -315.27 Mn
Jun 30, 2025 -264.71 Mn
Mar 31, 2025 -240.76 Mn
Dec 31, 2024 -216.31 Mn
Sep 30, 2024 -175.71 Mn
Jun 30, 2024 -156.64 Mn
Mar 31, 2024 -140.86 Mn
Dec 31, 2023 -179.98 Mn
Sep 30, 2023 -123.25 Mn
Jun 30, 2023 -108.80 Mn
Mar 31, 2023 -75.16 Mn
Dec 31, 2022 -61.71 Mn
Sep 30, 2022 -76.53 Mn
Jun 30, 2022 -62.09 Mn
Mar 31, 2022 -57.95 Mn
Dec 31, 2021 -52.91 Mn
Sep 30, 2021 -53.16 Mn
Jun 30, 2021 -44.54 Mn
Mar 31, 2021 -37.40 Mn
Dec 31, 2020 -34.08 Mn
Sep 30, 2020 -27.55 Mn
Jun 30, 2020 -27.98 Mn
Mar 31, 2020 -21.08 Mn
Dec 31, 2019 -19.56 Mn
Sep 30, 2019 -13.56 Mn
Jun 30, 2019 -10.56 Mn
Mar 31, 2019 -10.44 Mn