Protagonist Therapeutics PTGX
NASDAQ PTGX
$145.65 -3.15 (-2.12%)
As of: Sep 4, 2026 · 3:59 PM EDT

Protagonist Therapeutics (PTGX) EBITDA Margin (2017 - 2026)

Protagonist Therapeutics (PTGX) posted EBITDA Margin of 6.47% for Q1 2026, up 99.04% sequentially from 677.09% in Q4 2025, and up 6171.0% YoY from 0.1% in Q1 2025.

Analysis

Protagonist Therapeutics (PTGX) EBITDA Margin (2017 - 2026) Analysis & Trends

Protagonist Therapeutics has reported EBITDA Margin for 10 years, with the latest figure at 6.47% in Q1 2026.

  • Quarterly EBITDA Margin rose 6171.0% year-over-year to 6.47% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 192.36% (down 20582.0% YoY) and the FY2025 annual result came in at 343.63%, down 40184.0% from the prior year.
  • EBITDA Margin advanced to 6.47% in Q1 2026 per PTGX's latest filing, from 677.09% in the prior quarter.
  • Over five years, EBITDA Margin peaked at 80.92% in Q1 2024 and troughed at 4824.56% in Q2 2022.
  • A 5-year average of 751.28% and a median of 379.58% in 2022 frame the typical range for EBITDA Margin.
  • The widest YoY moves for EBITDA Margin: up 30605 bps in 2022, down 346112 bps in 2022.
  • Over 5 years, EBITDA Margin stood at 4824.56% in 2022, then surged by 101 bps to 46.1% in 2023, then surged by 67 bps to 76.84% in 2024, then sank by 981 bps to 677.09% in 2025, then jumped by 99 bps to 6.47% in 2026.
  • According to Business Quant data, EBITDA Margin over the past three periods registered 6.47%, 677.09%, and 985.17% for Q1 2026, Q4 2025, and Q3 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA Margin (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 37.40%
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 30.15%
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn 32.54%
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -562.07%
5 Revolution Medicines 44.33 Bn 44.33 Bn - -
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 19.06%
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn 17.93%
8 Royalty Pharma 28.45 Bn 27.61 Bn - 19.75%
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -0.36%
10 Protagonist Therapeutics 9.61 Bn 9.61 Bn - 74.37%
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 74.37%
Mar 31, 2026 -6.47%
Dec 31, 2025 -677.09%
Sep 30, 2025 -985.17%
Jun 30, 2025 -758.04%
Mar 31, 2025 -68.18%
Dec 31, 2024 76.84%
Sep 30, 2024 -886.70%
Jun 30, 2024 -930.96%
Mar 31, 2024 80.92%
Dec 31, 2023 46.10%
Dec 31, 2022 192,189.47%
Jun 30, 2022 -4,604.78%
Mar 31, 2022 -82.07%
Dec 31, 2021 -429.57%
Sep 30, 2021 -329.83%
Jun 30, 2021 -1,363.44%
Mar 31, 2021 -388.12%
Dec 31, 2020 -333.27%
Sep 30, 2020 -59.26%