Personalis (PSNL) Operating Income (2018 - 2026)

Personalis (PSNL) recorded quarterly Operating Income of -$32.2 million in Q1 2026, down 27.29% quarter-over-quarter from -$25.3 million in Q4 2025, and down 81.74% on a YoY basis from -$176.1 million in Q1 2025.

Personalis (PSNL) Operating Income (2018 - 2026) Analysis & Trends

Personalis' Operating Income history runs 9 years deep, the most recent figure standing at -$32.2 million for Q1 2026.

  • In Q1 2026, Operating Income fell 81.74% year-over-year to -$32.2 million; the TTM figure through Mar 2026 stood at -$102.5 million (down 52.83% YoY), while the FY2025 annual figure was -$88.1 million, down 28.99% from the prior year.
  • Operating Income was -$32.2 million for Q1 2026 at Personalis, down from -$25.3 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of -$14.4 million in Q3 2024 to a low of -$32.2 million in Q1 2026.
  • Historically, Operating Income has averaged -$24.4 million across 5 years, with a median of -$25.3 million in 2025.
  • The sharpest annual moves came in 2022 and 2024: Operating Income tumbled 126.63% in 2022, then jumped 53.29% in 2024.
  • A 5-year view of Operating Income shows it stood at -$32.1 million in 2022, then climbed by 25.29% to -$24.0 million in 2023, then grew by 24.45% to -$18.1 million in 2024, then slumped by 39.5% to -$25.3 million in 2025, then fell by 27.29% to -$32.2 million in 2026.
  • The last three Operating Income figures came in at -$32.2 million (Q1 2026), -$25.3 million (Q4 2025), and -$23.3 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Waters 29,902.70 Bn 29,902.24 Bn 1.11 Bn -47.00 Mn
2 Thermo Fisher Scientific 175.99 Bn 172.74 Bn 7.74 Bn 1.86 Bn
3 Danaher 129.87 Bn 124.18 Bn 3.59 Bn 1.34 Bn
4 Idexx Laboratories 44.75 Bn 44.55 Bn 722.74 Mn 362.59 Mn
5 Agilent Technologies 37.52 Bn 35.72 Bn 990.00 Mn 399.00 Mn
6 Iqvia Holdings 30.91 Bn 28.94 Bn 1.36 Bn 514.00 Mn
7 Natera 30.21 Bn 29.11 Bn 696.04 Mn -93.52 Mn
8 Illumina 24.19 Bn 23.04 Bn 721.00 Mn 209.00 Mn
9 Mettler Toledo International 23.12 Bn 23.06 Bn 555.82 Mn 238.95 Mn
10 Personalis 1.05 Bn 819.64 Mn 281,000.00 -32.16 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -32.16 Mn
Dec 31, 2025 -25.27 Mn
Sep 30, 2025 -23.29 Mn
Jun 30, 2025 -21.80 Mn
Mar 31, 2025 -17.70 Mn
Dec 31, 2024 -18.11 Mn
Sep 30, 2024 -14.38 Mn
Jun 30, 2024 -16.89 Mn
Mar 31, 2024 -18.88 Mn
Dec 31, 2023 -23.97 Mn
Sep 30, 2023 -30.79 Mn
Jun 30, 2023 -25.35 Mn
Mar 31, 2023 -29.83 Mn
Dec 31, 2022 -32.09 Mn
Sep 30, 2022 -27.26 Mn
Jun 30, 2022 -27.88 Mn
Mar 31, 2022 -28.31 Mn
Dec 31, 2021 -20.23 Mn
Sep 30, 2021 -17.69 Mn
Jun 30, 2021 -14.95 Mn