Personalis (PSNL) Gross Margin (2018 - 2026)
Personalis (PSNL) posted Gross Margin of 21.21% for Q2 2026, up 1068.1% on a QoQ basis from 1.82% in Q1 2026, and down 643.0% year-over-year from 3.91% in Q2 2025.
Powered by 
Analysis
Personalis (PSNL) Gross Margin (2018 - 2026) Analysis & Trends
Personalis has reported Gross Margin for 9 years, with the latest figure at 21.21% in Q2 2026.
- On a quarterly basis, Gross Margin fell 643.0% year-over-year to 21.21% in Q2 2026; TTM through Jun 2026 was 12.69%, a 1876.0% decrease from a year earlier, with the FY2025 full-year figure at 22.65%, down 905.0% from the prior year.
- Gross Margin was 21.21% for Q2 2026 at Personalis, up from 1.82% in the prior quarter.
- The five-year high for Gross Margin was 35.59% in Q2 2024, with the low at 1.82% in Q1 2026.
- Average Gross Margin over 5 years is 23.11%, with a median of 25.77% recorded in 2023.
- The sharpest annual moves came in 2024 and 2026: Gross Margin soared 1494 bps in 2024, then plunged 3316 bps in 2026.
- Over 5 years, Gross Margin stood at 13.83% in 2022, then surged by 91 bps to 26.45% in 2023, then grew by 2 bps to 27.08% in 2024, then plunged by 60 bps to 10.95% in 2025, then jumped by 94 bps to 21.21% in 2026.
- The last three Gross Margin figures came in at 21.21% (Q2 2026), 1.82% (Q1 2026), and 10.95% (Q4 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Natera | 53.05 Bn | 51.95 Bn | 486.15 Mn | 64.58% |
| 2 | Quest Diagnostics | 27.19 Bn | 26.87 Bn | 1.03 Bn | 33.75% |
| 3 | Labcorp Holdings | 25.93 Bn | 25.81 Bn | 1.11 Bn | 29.80% |
| 4 | Guardant Health | 23.97 Bn | 22.91 Bn | 219.03 Mn | 65.39% |
| 5 | Tempus AI | 13.64 Bn | 12.82 Bn | 274.25 Mn | 71.70% |
| 6 | Caris Life Sciences | 8.47 Bn | 7.68 Bn | 182.38 Mn | 69.16% |
| 7 | Sotera Health | 5.35 Bn | 4.99 Bn | 177.96 Mn | 55.38% |
| 8 | BillionToOne | 4.96 Bn | 4.41 Bn | 77.11 Mn | 70.45% |
| 9 | Adaptive Biotechnologies | 4.55 Bn | 4.21 Bn | 51.39 Mn | 71.82% |
| 10 | Personalis | 1.74 Bn | 1.53 Bn | 4.74 Mn | 21.21% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 21.21% |
| Mar 31, 2026 | 1.82% |
| Dec 31, 2025 | 10.95% |
| Sep 30, 2025 | 13.20% |
| Jun 30, 2025 | 27.65% |
| Mar 31, 2025 | 34.98% |
| Dec 31, 2024 | 27.08% |
| Sep 30, 2024 | 34.02% |
| Jun 30, 2024 | 35.59% |
| Mar 31, 2024 | 28.13% |
| Dec 31, 2023 | 26.45% |
| Sep 30, 2023 | 19.08% |
| Jun 30, 2023 | 28.70% |
| Mar 31, 2023 | 25.08% |
| Dec 31, 2022 | 13.83% |
| Sep 30, 2022 | 16.68% |
| Jun 30, 2022 | 23.47% |
| Mar 31, 2022 | 28.09% |
| Dec 31, 2021 | 38.66% |
| Sep 30, 2021 | 36.23% |
API Access
Personalis Gross Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=gross-margin&ticker=PSNL&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "gross-margin", "ticker": "PSNL", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=gross-margin&ticker=PSNL&period=max&api_key=YOUR_API_KEY");
const data = await res.json();