ProQR Therapeutics (PRQR) Net Margin (2021 - 2025)
ProQR Therapeutics recorded quarterly Net Margin of 167.32% in Q4 2025, up 56.28% quarter-over-quarter from 382.69% in Q3 2025, and up 4638.0% year-over-year from 3.53% in Q4 2024.
ProQR Therapeutics' Net Margin history runs 5 years deep, the most recent figure standing at 167.32% for Q4 2025.
- In Q4 2025, Net Margin rose 4638.0% year-over-year to 167.32%; the TTM figure through Dec 2025 stood at 265.77% (down 11723.0% YoY), while the FY2025 annual figure was 265.21%, down 11835.0% from the prior year.
- Net Margin came in at 167.32% for Q4 2025 at ProQR Therapeutics, up from 382.69% in the prior quarter.
- In the past five years, Net Margin ranged from a high of 42.7% in Q2 2024 to a low of 7623.85% in Q4 2021.
- A 5-year average of 1460.0% and a median of 441.24% in 2023 frame the typical range for Net Margin.
- On a YoY basis, Net Margin climbed as much as 577704 bps in 2022 and fell as far as 113905 bps in 2022.
- ProQR Therapeutics' Net Margin stood at 7623.85% in 2021, then surged by 76 bps to 1846.81% in 2022, then soared by 92 bps to 150.3% in 2023, then plunged by 42 bps to 213.7% in 2024, then advanced by 22 bps to 167.32% in 2025.
- According to Business Quant data, Net Margin over the past three periods registered 167.32%, 382.69%, and 336.94% for Q4 2025, Q3 2025, and Q2 2025 respectively.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | 0.82% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 34.53% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 20.17% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 17.65% |
| 10 | ProQR Therapeutics | 174.11 Mn | 66.54 Mn | - | -167.32% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -167.32% |
| Sep 30, 2025 | -382.69% |
| Jun 30, 2025 | -336.94% |
| Mar 31, 2025 | -231.25% |
| Dec 31, 2024 | -213.70% |
| Sep 30, 2024 | -220.79% |
| Jun 30, 2024 | -42.70% |
| Mar 31, 2024 | -172.09% |
| Dec 31, 2023 | -150.30% |
| Sep 30, 2023 | -441.24% |
| Jun 30, 2023 | -663.32% |
| Mar 31, 2023 | -1,397.25% |
| Dec 31, 2022 | -1,846.81% |
| Sep 30, 2022 | -2,864.62% |
| Jun 30, 2022 | -1,473.12% |
| Mar 31, 2022 | -1,248.58% |
| Dec 31, 2021 | -7,623.85% |
| Sep 30, 2021 | -1,725.57% |
| Jun 30, 2021 | -6,537.86% |