Prime Medicine (PRME) Net Income (2021 - 2026)
Prime Medicine (PRME) posted Net Income of -$228.7 million for Q1 2026, down 381.22% on a QoQ basis from -$47.5 million in Q4 2025, and down 340.77% year-over-year from $95.0 million in Q1 2025.
Prime Medicine (PRME) Net Income (2021 - 2026) Analysis & Trends
Prime Medicine's Net Income history runs 6 years deep, the most recent figure standing at -$228.7 million for Q1 2026.
- Quarterly Net Income fell 340.77% year-over-year to -$228.7 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$453.2 million (down 124.36% YoY) and the FY2025 annual result came in at -$204.2 million, down 4.25% from the prior year.
- Net Income was -$228.7 million for Q1 2026 at Prime Medicine, down from -$47.5 million in the prior quarter.
- Across five years, Net Income topped out at -$23.8 million in Q1 2022 and bottomed at -$228.7 million in Q1 2026.
- A 5-year average of -$60.1 million and a median of -$47.5 million in 2025 frame the typical range for Net Income.
- Annual changes were most pronounced in 2022 — Net Income jumped 37.56% — and 2026, when it slumped 340.77%.
- Prime Medicine's Net Income stood at -$39.3 million in 2022, then plunged by 67.1% to -$65.6 million in 2023, then surged by 35.6% to -$42.3 million in 2024, then fell by 12.42% to -$47.5 million in 2025, then plunged by 381.22% to -$228.7 million in 2026.
- Business Quant data shows PRME's Net Income at -$228.7 million in Q1 2026, -$47.5 million in Q4 2025, and -$124.4 million in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Income (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -37.09 Mn |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 227.36 Mn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -3.31 Mn |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 1.03 Bn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 727.20 Mn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | -26.94 Mn |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 362.00 Mn |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | -453.82 Mn |
| 10 | Prime Medicine | 525.98 Mn | 525.98 Mn | - | -228.71 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -228.71 Mn |
| Dec 31, 2025 | -47.53 Mn |
| Sep 30, 2025 | -124.40 Mn |
| Jun 30, 2025 | -52.59 Mn |
| Mar 31, 2025 | -51.89 Mn |
| Dec 31, 2024 | -42.28 Mn |
| Sep 30, 2024 | -52.52 Mn |
| Jun 30, 2024 | -55.33 Mn |
| Mar 31, 2024 | -45.76 Mn |
| Dec 31, 2023 | -65.64 Mn |
| Sep 30, 2023 | -50.71 Mn |
| Jun 30, 2023 | -42.39 Mn |
| Mar 31, 2023 | -39.40 Mn |
| Dec 31, 2022 | -39.28 Mn |
| Sep 30, 2022 | -29.35 Mn |
| Jun 30, 2022 | -29.35 Mn |
| Mar 31, 2022 | -23.84 Mn |
| Dec 31, 2021 | -62.91 Mn |
| Sep 30, 2021 | -16.41 Mn |