Prime Medicine (PRME) Gains from Investment Securities (2022 - 2025)

Prime Medicine (PRME) reported Gains from Investment Securities of -$83.3 million for Q4 2025, down 138975.0% on a YoY basis from N/an in Q4 2024, and down 197.66% quarter-over-quarter from $85.3 million in Q3 2025.

Prime Medicine (PRME) Gains from Investment Securities (2022 - 2025) Analysis & Trends

Prime Medicine has reported Gains from Investment Securities for 4 years, with the latest figure at -$83.3 million in Q4 2025.

  • For the quarter ending Q4 2025, Gains from Investment Securities fell 138975.0% year-over-year to -$83.3 million; the trailing twelve-month figure through Mar 2026 stood at $1.5 million (up 103.2% YoY), and the FY2025 full-year result was $432000.0, up 189.26% from the prior year.
  • Gains from Investment Securities for Q4 2025 stood at -$83.3 million, down from $85.3 million in the prior quarter.
  • The five-year high for Gains from Investment Securities was $85.3 million in Q3 2025, with the low at -$83.3 million in Q4 2025.
  • Historically, Gains from Investment Securities has averaged -$586285.7 across 4 years, with a median of -$244000.0 in 2022.
  • Annual changes were most pronounced in 2024 — Gains from Investment Securities soared 2741.68% — and 2025, when it sank 138975.0%.
  • Prime Medicine's Gains from Investment Securities stood at -$36.7 million in 2022, then soared by 108.14% to $3.0 million in 2023, then slumped by 97.99% to $60000.0 in 2024, then slumped by 138975.0% to -$83.3 million in 2025.
  • The last three Gains from Investment Securities figures came in at -$83.3 million (Q4 2025), $85.3 million (Q3 2025), and -$505000.0 (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn -
7 Psyence Biomedical 212.16 Bn 212.16 Bn -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn
9 Abivax 91.96 Bn 91.96 Bn -
10 Prime Medicine 572.02 Mn 572.02 Mn -

Historic Data

Download Data
DateValue
Dec 31, 2025 -83.33 Mn
Dec 31, 2025 -83.33 Mn
Sep 30, 2025 85.32 Mn
Sep 30, 2025 85.32 Mn
Jun 30, 2025 -505,000.00
Jun 30, 2025 -505,000.00
Mar 31, 2025 -1.06 Mn
Mar 31, 2025 -1.06 Mn
Dec 31, 2024 60,000.00
Dec 31, 2024 60,000.00
Sep 30, 2024 -45.48 Mn
Sep 30, 2024 -45.48 Mn
Mar 31, 2024 44.94 Mn
Mar 31, 2024 44.94 Mn
Dec 31, 2023 2.99 Mn
Dec 31, 2023 2.99 Mn
Sep 30, 2023 -6.28 Mn
Sep 30, 2023 -6.28 Mn
Jun 30, 2023 4.97 Mn
Jun 30, 2023 4.97 Mn