Prime Medicine (PRME) EBT (2021 - 2026)
Prime Medicine (PRME) posted EBT of -$228.7 million for Q1 2026, down 381.22% on a QoQ basis from -$47.5 million in Q4 2025, and down 340.77% year-over-year from $95.0 million in Q1 2025.
Prime Medicine (PRME) EBT (2021 - 2026) Analysis & Trends
Prime Medicine's EBT history runs 6 years deep, the most recent figure standing at -$228.7 million for Q1 2026.
- Quarterly EBT fell 340.77% year-over-year to -$228.7 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$453.2 million (down 124.21% YoY) and the FY2025 annual result came in at -$204.2 million, down 4.25% from the prior year.
- EBT was -$228.7 million for Q1 2026 at Prime Medicine, down from -$47.5 million in the prior quarter.
- Across five years, EBT topped out at -$24.4 million in Q1 2022 and bottomed at -$228.7 million in Q1 2026.
- A 5-year average of -$60.1 million and a median of -$47.5 million in 2025 frame the typical range for EBT.
- Annual changes were most pronounced in 2022 — EBT soared 35.85% — and 2026, when it slumped 340.77%.
- Prime Medicine's EBT stood at -$39.5 million in 2022, then slumped by 66.32% to -$65.6 million in 2023, then surged by 35.6% to -$42.3 million in 2024, then fell by 12.42% to -$47.5 million in 2025, then plunged by 381.22% to -$228.7 million in 2026.
- Business Quant data shows PRME's EBT at -$228.7 million in Q1 2026, -$47.5 million in Q4 2025, and -$124.4 million in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -36.97 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | -15.31 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 259.22 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.25 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 831.20 Mn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | -26.94 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | 438.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | -453.82 Mn |
| 10 | Prime Medicine | 524.20 Mn | 524.20 Mn | - | -228.71 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -228.71 Mn |
| Dec 31, 2025 | -47.53 Mn |
| Sep 30, 2025 | -124.40 Mn |
| Jun 30, 2025 | -52.59 Mn |
| Mar 31, 2025 | -51.89 Mn |
| Dec 31, 2024 | -42.28 Mn |
| Sep 30, 2024 | -52.52 Mn |
| Jun 30, 2024 | -55.46 Mn |
| Mar 31, 2024 | -45.63 Mn |
| Dec 31, 2023 | -65.64 Mn |
| Sep 30, 2023 | -50.82 Mn |
| Jun 30, 2023 | -42.35 Mn |
| Mar 31, 2023 | -39.60 Mn |
| Dec 31, 2022 | -39.47 Mn |
| Sep 30, 2022 | -29.14 Mn |
| Jun 30, 2022 | -29.79 Mn |
| Mar 31, 2022 | -24.37 Mn |
| Dec 31, 2021 | -61.53 Mn |
| Sep 30, 2021 | -18.78 Mn |