Prime Medicine (PRME) EBT (2021 - 2026)
Prime Medicine (PRME) reported EBT of -$49.6 million for Q1 2026, up 4.35% on a YoY basis from -$47.6 million in Q1 2025, and down 4.44% quarter-over-quarter from -$47.5 million in Q4 2025.
Prime Medicine (PRME) EBT (2021 - 2026) Analysis & Trends
Prime Medicine has reported EBT for 6 years, with the latest figure at -$49.6 million in Q1 2026.
- For the quarter ending Q1 2026, EBT rose 4.35% year-over-year to -$49.6 million; the trailing twelve-month figure through Mar 2026 stood at -$202.6 million (changed 0.22% YoY), and the FY2025 full-year result was -$204.2 million, down 4.25% from the prior year.
- EBT for Q1 2026 stood at -$49.6 million, down from -$47.5 million in the prior quarter.
- The five-year high for EBT was -$24.4 million in Q1 2022, with the low at -$65.6 million in Q4 2023.
- Historically, EBT has averaged -$45.4 million across 5 years, with a median of -$47.5 million in 2025.
- Annual changes were most pronounced in 2022 — EBT soared 35.85% — and 2023, when it tumbled 74.4%.
- Prime Medicine's EBT stood at -$39.5 million in 2022, then plunged by 66.32% to -$65.6 million in 2023, then soared by 35.6% to -$42.3 million in 2024, then slipped by 12.42% to -$47.5 million in 2025, then fell by 4.44% to -$49.6 million in 2026.
- The last three EBT figures came in at -$49.6 million (Q1 2026), -$47.5 million (Q4 2025), and -$52.8 million (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBT (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | -26.94 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -2.97 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 19.60 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.18 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -15.31 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | -1.50 Mn |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.25 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -56.48 Mn |
| 10 | Prime Medicine | 572.02 Mn | 572.02 Mn | - | -49.63 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -49.63 Mn |
| Dec 31, 2025 | -47.53 Mn |
| Sep 30, 2025 | -52.83 Mn |
| Jun 30, 2025 | -52.59 Mn |
| Mar 31, 2025 | -51.89 Mn |
| Dec 31, 2024 | -42.28 Mn |
| Sep 30, 2024 | -52.52 Mn |
| Jun 30, 2024 | -55.46 Mn |
| Mar 31, 2024 | -45.63 Mn |
| Dec 31, 2023 | -65.64 Mn |
| Sep 30, 2023 | -50.82 Mn |
| Jun 30, 2023 | -42.35 Mn |
| Mar 31, 2023 | -39.60 Mn |
| Dec 31, 2022 | -39.47 Mn |
| Sep 30, 2022 | -29.14 Mn |
| Jun 30, 2022 | -29.79 Mn |
| Mar 31, 2022 | -24.37 Mn |
| Dec 31, 2021 | -61.53 Mn |
| Sep 30, 2021 | -18.78 Mn |